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Eliminating bottlenecks for efficient bioanalysis /
Bioanalysis, commonly defined as the quantitative analysis of drugs, metabolites and biomarkers in biological matrices, is an integral part of various activities within the entire drug discovery and development process. With the well-documented declining return on investment of R & D in the phar...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Future Science Group,
2014.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Eliminating bottlenecks for efficient bioanalysis: practices and applications in drug discovery and development
- Automated method development of sample preparation
- Strategies for high-throughput sample analysis
- Enabling software for high-throughput bioanalysis
- Sample pooling approaches in discovery bioanaÂƯlysis
- Quantitative bioanalysis by microflow LCâ#x80;#x93;MS to support discovery-based pharmacoÂƯkinetic studies
- The current status and future perspective on high-resolution MS in regulated bioanalysis
- Bottlenecks in bioanaÂƯlysis: where do they come from and how to remove them?Discovery to development: bioanalytical considerations that can facilitate the transition
- Use of fit-for-purpose quality requirements in bioanalysis
- Incurred sample reanalysis evaluation and impact on drug preclinical and clinical development
- Tissue analysis and tissue imaging
- BioanaÂƯlysis supporting disease biomarker discovery and validation
- BioanaÂƯlysis of biomarkers in support of drug discovery and development
- MS-based protein quantification in a discovery setting
- MS-based protein quantitation in regulated drug development_GoBack
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- Background & principles of microflow LCâ#x80;#x93;MS
- Microflow LC/MS hardware Practical considerations with microflow LCâ#x80;#x93;MS
- Application of microflow LCâ#x80;#x93;MS in discovery bioanalysis
- Future perspectives
- HRMS in discovery setting
- The current status in the development arena
- Applications in bioanalysis that can benefit from using HRMS
- Challenges of adopting HRMS in regulated bioanalytical laboratories
- Conclusions
- New tools for the regulated bioanalytical scientist: more possibilities or more data?
- Instrument validation
- Bioanalytical method establishment
- When to validate?
- What to analyse?Interactions outside bioanaÂƯlysis
- Removing bottlenecks in regulated bioanaÂƯlysis
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