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New developments in chromatin research /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hauppauge, N.Y. :
Nova Science Publisher's, Incorporated,
[2012]
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| Colección: | Genetics - Research and Issues.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- NEW DEVELOPMENTS IN CHROMATIN RESEARCH; NEW DEVELOPMENTS IN CHROMATIN RESEARCH; CONTENTS ; PREFACE; THE VARIED FUNCTIONS OF AURORA KINASES A AND B IN MITOSIS AND CARCINOGENESIS ; ABSTRACT ; INTRODUCTION ; AURORA A KINASE ; Aurora A Localization ; Regulation of Aurora A Protein Levels ; Aurora A Mitotic Functions; Aurora A Functions in Mitotic Entry and Centrosomal Regulation ; Aurora A Functions in Spindle Assembly; Regulation of Aurora A Activity ; Aurora A and Cancer; AURORA B KINASE ; Aurora B Localization ; Regulation of Aurora B Levels ; Regulation of Aurora B Activity.
- Aurora B Mitotic Functions Aurora B Functions in Chromosome Structure and Alignment ; Aurora B Functions in Chromosome Segregation and Anaphase Onset ; Aurora B Functions in Cytokinesis ; Aurora B and Cancer ; PERSPECTIVES
- IS THERE A SIGNALING CROSS-TALK BETWEEN AURORA A AND AURORA B? ; ACKNOWLEDGMENTS ; REFERENCES ; NEW DEVELOPMENTS IN CHROMATIN RESEARCH: AN EPIGENETIC PERSPECTIVE ; ABSTRACT ; 1. INTRODUCTION ; 2. CHROMATIN STRUCTURE AND NUCLEOSOME DYNAMICS; 2.1. DNA Structure and Chromatin Fibers ; 2.2. Nucleosome Positioning ; 2.3. Nucleosome Dynamics and Gene Regulation.
- 3. HISTONE POST-TRANSLATIONAL MODIFICATIONS AND CHROMATIN STRUCTURE3.1. Types of Histone PTMs; 3.1.1. Histone Acetylation; 3.1.2. Histone Methylation ; 3.1.3. Other Modifications ; 3.2. Crosstalk between Histone Modifications ; 3.3. Distribution of Histone Modifications within Genomic Domains; 4. DNA MODIFICATIONS AND CHROMATIN STRUCTURE; 4.1. DNA Methylation and Demethylation ; 4.1.1. DNA Methylation ; 4.1.2. DNA Demethylation ; 4.2. Crosstalk between DNA Marks and Histone PTMs ; 4.3. Function of MBD Proteins as Chromatin Architectural Proteins ; CONCLUSION ; ACKNOWLEDGMENTS.
- GRANT INFORMATION REFERENCES ; SPERM CHROMATIN INTEGRITY, DNA FRAGMENTATION AND MALE FERTILITY ; ABSTRACT ; 1. SPERM CHROMATIN STRUCTURE ; Balhorn's Model ; Toroids; Histone Bound DNA; Chromatin Remodelling during Spermatogenesis ; Chromosome Territories; 2. SPERM CHROMATIN INTEGRITY, DNA FRAGMENTATION AND MALE FERTILITY ; Origin of Sperm DNA Fragmentation ; Incomplete Repair of DNA Breaks during Chromatin Remodelling ; Aberrant Protamination ; Defective Apoptosis ; Excessive Production of ROS in the Ejaculate; Other Factors; Methods of Evaluation of Sperm DNA Fragmentation.
- Sperm Chromatin Structure Assay (SCSA) Terminal Deoxytransferase Mediated deoxyUridine Triphosphate Nick End Labelling (TUNEL); Comet Assay ; Sperm Chromatin Dispersion Test ; Impact of Sperm Nuclear Integrity on Male Fertility ; Impact of Sperm Nuclear Integrity on Reproduction ; Natural Conception; ART Conception ; 3. FUTURE PERSPECTIVES ; Fundamental Research Is Essential ; Standardization of the Methods for Sperm DNA Damage Evaluation ; Questions Concerning Factors Influencing the Predictive Value of SDF ; Long-Term Follow Up of ART Children ; REFERENCES.