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Handbook of Epigenetics : the New Molecular and Medical Genetics.

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Tollefsbol, Trygve O.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Saint Louis : Elsevier Science, 2017.
Edición:2nd ed.
Temas:
Acceso en línea:Texto completo

MARC

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245 1 0 |a Handbook of Epigenetics :  |b the New Molecular and Medical Genetics. 
250 |a 2nd ed. 
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300 |a 1 online resource (684 pages) 
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505 0 |a Cover; Title page; Copyright page; Contents; Contributors; Preface; Section I -- Overview; Chapter 1 -- An Overview of Epigenetics; Introduction; Molecular Mechanisms of Epigenetics; Methods in Epigenetics; Model Organisms of Epigenetics; Factors Influencing Epigenetic Changes; Evolutionary Epigenetics; Epigenetic Epidemiology; Epigenetics and Human Disease; Epigenetic Therapy; The Future of Epigenetics; Conclusions; References; Section II -- Molecular Mechanisms of Epigenetics; Chapter 2 -- Mechanisms of DNA Methylation and Demethylation During Mammalian Development; Introduction. 
505 8 |a DNA MethylationMaintenance DNA Methylation; DNMT1; UHRF1; De Novo DNA Methylation; DNMT3A and DNMT3B; DNMT3L; DNA Demethylation; Passive DNA Demethylation; Active DNA Demethylation; TET Proteins; TET-Dependent Demethylation Pathways; TET Proteins in Development; Conclusions; Glossary; Abbreviations; Acknowledgments; References; Chapter 3 -- Mechanisms of Histone Modifications; Introduction; Histone Modifications; Proline Isomerization; Citrullination; Ubiquitination; Role of Histone Ubiquitination in Transcription Regulation; Role of Histone Ubiquitination in DNA Damage Response; Sumoylation. 
505 8 |a ADP-RibosylationPhosphorylation; Role of Histone Phosphorylation in Transcription Regulation; Role of Histone Phosphorylation in DNA Damage Response; Methylation; Role of Histone Methylation in Transcription Regulation; Role of Histone Methylation in DNA Repair; Acetylation; GNAT Superfamily; MYST Superfamily; P300/CBP; Nuclear Hormone-Related HATs; HAT Complexes; Histone Deacetylases; Role of Histone Acetylation in Transcription Regulation; Role of Histone Acetylation in DNA Repair; Conclusions; References; Chapter 4 -- The Epigenetics of Noncoding RNA; Introduction; The Noncoding RNA. 
505 8 |a Genetics and EpigeneticsEpigenetic Regulation of miRNA Expression; Epitranscriptomics of miRNAs; Regulation of Epigenetics by miRNAs; Plausible Interdependence Between miRNA Targeting and mRNA Methylation; Epigenetic Regulation of lncRNAs; Epitranscriptomics of lncRNA; Regulation of Epigenetics by lncRNAs; Conclusions; Abbreviations; Acknowledgments; References; Chapter 5 -- Prions and Prion-Like Phenomena in Epigenetic Inheritance; Structural Heredity; Prions of Saccharomyces cerevisiae and Podospora anserina; Self Driven Assembly of Hsp60 Mitochondrial Chaperonin. 
505 8 |a Cytotaxis of Cilia and Other Complex StructuresMixed Heredity: A Prion That Propagates by Covalent Autoactivation; Regulatory Inheritance; The Lactose Operon and its Positive Feedback Loop; Crippled Growth, a Self-Sustained and Mitotically Inheritable Signaling Pathway in the Filamentous Fungus Podospora anserina; The White/Opaque Switch of Candida albicans, an Epigenetic Switch at the Transcription Level; Conclusions; References; Chapter 6 -- Higher-Order Chromatin Organization in Diseases: From Chromosomal Position Effect to Phenotype Variegation; Introduction; CPE in Model Organisms. 
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