Engineering Neural Tissue from Stem Cells /

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Engineering Neural Tissue from Stem Cells covers the basic knowledge needed to understand the nervous system and how existing cells can be used to create neural tissue. This book presents a broad range of topics related to the design requirements for engineering neural tissue from stem cells. It beg...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Willerth, Stephanie (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Academic Press, ©2017.
Temas:
Tissue engineering.
Nerve tissue > Cultures and culture media.
Stem cells > Therapeutic use.
Nerve tissue.
Stem cells.
Tissue Engineering
Nerve Tissue
Stem Cells
Génie tissulaire.
Tissu nerveux > Cultures et milieux de culture.
Cellules souches > Emploi en thérapeutique.
Tissu nerveux.
Cellules souches.
MEDICAL > Physiology.
SCIENCE > Life Sciences > Human Anatomy & Physiology.
Stem cells
Nerve tissue
Nerve tissue > Cultures and culture media
Tissue engineering
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover
  • Engineering Neural Tissue from Stem Cells
  • Copyright
  • Contents
  • Author Biography
  • Foreword
  • Acknowledgments
  • Chapter 1 The need for engineering neural tissue using stem cells
  • 1 Overview of the Nervous System
  • 2 Demand for Cures for Neurodegenerative Diseases and Disorders Using Neural Tissue Engineering
  • 2.1 Alzheimer's Disease
  • 2.2 Parkinson's Disease
  • 2.3 Huntington's Disease
  • 2.4 Amyotrophic Lateral Sclerosis
  • 2.5 Multiple Sclerosis
  • 2.6 Traumatic Brain Injury
  • 2.7 Traumatic Spinal Cord Injury
  • 3 The Discovery of Stem Cells and Their Impact on Tissue Engineering
  • 4 The Need for Interdisciplinary Approaches for Treating Neurological Disorders
  • Relevant Websites
  • References
  • Chapter 2 Introduction to the nervous system
  • 1 Introduction
  • 2 The Structure and Function of the Central Nervous System
  • 2.1 Brain
  • 2.1.1 Cerebrum
  • 2.1.2 Diencephalon
  • 2.1.3 Brainstem
  • 2.1.4 Cerebellum
  • 2.2 Spinal Cord
  • 3 Peripheral Nervous System
  • 4 Cells of the Nervous System
  • 4.1 Neurons
  • 4.2 Oligodendrocytes
  • 4.3 Astrocytes
  • 4.4 Schwann Cells
  • 4.5 Other Cells of the Nervous System
  • 5 Conclusions
  • Additional Resources
  • More Reading on History of Understanding Neuroanatomy Structure and Function
  • Books on Patient H.M.
  • Resources Associated With Gross Neuroanatomy
  • Gray's Anatomy (Current and Original Editions)
  • Resources Associated With Cellular Level Neuroanatomy
  • References
  • Chapter 3 Stem cells and their applications in repairing the damaged nervous system
  • 1 Introduction
  • 2 Discovery of Bone Marrow Stem Cells, Their Role in Nervous System, and Their Potential Applications in Treating the Dam ...
  • 2.1 Discovery of Bone Marrow Stem Cells and Their Role in the Body
  • 2.2 Application of Mesenchymal Stem Cell Therapies for Applications in the Nervous System.
  • 3 Discovery of Neural Stem Cells and Their Applications for Nervous System Repair
  • 4 Derivation of Human Embryonic Stem Cells and Their Applications for Nervous System Repair
  • 5 Derivation of Induced Pluripotent Stem Cells and Their Applications for Nervous System Repair
  • 6 Direct Reprogramming of Mature Cells Into Functional Neural Cells
  • 7 Concluding Remarks on Stem Cells and Their Potential as Cell Therapies
  • Relevant Resources
  • References
  • Chapter 4 Design considerations when engineering neural tissue from stem cells
  • 1 Introduction
  • 2 Chemical Properties of Neural Tissue
  • 2.1 Proteins of the Extracellular Matrix and Their Function
  • 2.1.1 Collagen
  • 2.1.2 Fibronectin
  • 2.1.3 Laminin
  • 2.1.4 Elastin
  • 2.1.5 Glycoproteins found in the extracellular matrix of the nervous system
  • 2.2 Polysaccharides Found in the Extracellular Matrix and Their Function
  • 2.2.1 Hyaluronan/hyaluronic acid
  • 2.2.2 Chondroitin sulfate
  • 2.2.3 Heparin and heparan sulfate
  • 2.2.4 Keratan sulfate/keratosulfate
  • 2.3 Composition of the Extracellular Matrix of the Brain and the Spinal Cord
  • 2.4 Composition of the Extracellular Matrix in the Peripheral Nervous System
  • 2.5 Role of Growth Factors in the Extracellular Matrix
  • 2.6 The Role of Small Molecules in Neuronal Development
  • 3 Mechanical Properties of Neural Tissue
  • 3.1 The Physical Topography of the Extracellular Matrix and Its Effect on Cellular Behavior
  • 3.2 The Mechanical Properties of Neural Tissue and How They Relate to Stem Cell Behavior
  • 4 Implications for Design of Biomaterial Scaffolds
  • Additional Resources
  • Cell Biology Textbooks for Further Reading About the Extracellular Matrix
  • Textbooks About Biomaterials for Further Reading
  • Textbooks About Tissue Engineering for Further Reading
  • Companies That 3D Print Tissues
  • References.
  • Chapter 5 Natural biomaterials for engineering neural tissue from stem cells
  • 1 Introduction
  • 2 Pure Biomaterials
  • 2.1 Proteins
  • 2.1.1 Collagen
  • 2.1.2 Fibrin
  • 2.1.3 Fibronectin
  • 2.1.4 Silk
  • 2.1.5 Laminin
  • 2.2 Polysaccharides
  • 2.2.1 Agarose
  • 2.2.2 Alginate
  • 2.2.3 Chitosan
  • 2.2.4 Methylcellulose and nitrocellulose
  • 2.2.5 Dextran
  • 2.2.6 Hyaluronan/hyaluronic acid
  • 2.3 Mixtures of the Different Natural Extracellular Matrix Components as Scaffolds for Controlling Stem Cell Behavior for ...
  • 3 Decellularized Biomaterials
  • 4 Future Directions
  • Additional Resources
  • Links to Web Resources About Biomaterials
  • Textbooks About Biomaterials for Further Reading
  • Textbooks About Tissue Engineering for Further Reading
  • References
  • Chapter 6 Synthetic biomaterials for engineering neural tissue from stem cells
  • 1 Introduction
  • 2 Types of Synthetic Scaffolds
  • 2.1 Poly (Ethylene Glycol)/Poly (Ethylene Oxide)
  • 2.2 Poly (Glycolic Acid)/Poly (Lactic Acid)/Poly (Lactic-co-glycolic Acid)
  • 2.3 Poly (caprolactone)
  • 2.4 Poly (2-Hydroxyethyl Methacrylate)
  • 2.5 Polypyrrole
  • 2.6 Poly(dimethylsiloxane)
  • 2.7 Self-Assembling Peptides
  • 2.8 Other Potential Polymers Suitable for Applications in Neural Tissue Engineering Using Stem Cells
  • 3 The Development of "Smart" Biomaterials That Respond to Stimuli
  • 4 Future Directions
  • Additional Resources
  • Link to the Chart Showing the Single Letter Abbreviations for Each Amino Acid
  • Links to Web Resources About Biomaterials
  • Textbooks About Biomaterials for Further Reading
  • Textbooks About Tissue Engineering for Further Reading
  • References
  • Chapter 7 Drug delivery systems for engineering neural tissue
  • 1 Introduction
  • 2 Diffusion-Based Drug Delivery Systems
  • 2.1 Hydrogels
  • 2.2 Microparticles
  • 2.3 Nanoparticles
  • 2.4 Microfibers
  • 2.5 Nanofibers.
  • 3 Affinity-Based Drug Delivery Systems
  • 3.1 Heparin-Based Drug Delivery Systems
  • 3.2 Other Types of Affinity-Based Drug Delivery Systems
  • 4 Immobilization-Based Drug Delivery Systems
  • 5 Electrically Controlled Drug Delivery Systems
  • 6 Optically Controlled Drug Delivery Systems
  • 7 Future Directions
  • Additional Resources
  • Books Related to Drug Delivery
  • References
  • Chapter 8 New technologies for engineering neural tissue from stem cells
  • 1 Introduction to New Technologies for Engineering Neural Tissues From Stem Cells
  • 2 Generation of Neural Organoids From Stem Cells
  • 3 The Use of 3D Bioprinting to Produce on Demand Neural Tissues
  • 4 In Vitro and In Vivo Engineering of Neural Tissue From Somatic Cells
  • 5 Genome Editing for Engineering Neural Tissue
  • 6 Optogenetics and Designer Receptors Exclusively Activated by Designer Drugs (DREADDs)
  • 7 Conclusions
  • Additional Resources
  • Resources Related to 3D Bioprinting
  • Resources Related to Organoids
  • Resources Related to Direct Reprogramming of Cells
  • Resources Related to Gene Editing
  • Resources Related to Optogenetics and DREDDs
  • References
  • Index
  • Back Cover.

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