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Anti-obesity drug discovery and development. Volume 3 /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Sharjah :
Bentham Science Publishers,
2017.
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| Colección: | Anti-Obesity Drug Discovery and Development.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- PREFACE; List of Contributors ; Current Status of Medical Therapy and New Targets for Anti-Obesity Drug Development ; Chihiro Okuma, Yukihito Ishii and Takeshi Ohta*; INTRODUCTION; Approved Drugs; Phentermine; Mazindol; Fenfluramine/Dexfenfluramine; Orlistat; Shibutramine; Rimonabant; Qsymia; BELVIQ (Lorcaserin); Contrave; New Drug Targets (Table 3); Late Phase Clinical Development; Early Phase Clinical Stage Development or Pre-Clinical Development Stage Late Phase Clinical Development; Future Prospects; Obesity Animal Models; ob/ob Mouse; db/db Mouse; KK-Ay Mouse; TSOD Mouse.
- SDT fatty RatZF Rat; ZDF Rat; cp/cp Rat; WBN/Kob fatty Rat; DIO Models; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Unravelling Potential Anorexigen Effects of Nesfatin-1: How Homeostatic Mechanisms Help Balance Excess Calories ; Carmine Finelli*; INTRODUCTION; Nesfatin-1/NUCB-2 and Anorexigenic Effect; The Oxytocin Pathway in Nesfatin-1's Inhibitory Effect on Food Intake; Nesfatin-1 and CRF; Nesfatin-1 and Anti-Obesity Treatment; Nesfatin-1 and Food Behaviour Control; Nesfatin-1 and Signaling Pathway; Nesfatin-1 and Eating Disorders; CONCLUSIVE REMARKS; CONFLICT OF INTEREST.
- ACKNOWLEDGEMENTSABBREVIATIONS; REFERENCES; Proteomics in the Characterization of New Target Therapies in Pediatric Obesity Treatment ; Gillian E. Walker1,*, Marilisa De Feudis1, Marta Roccio1, Gianni Bona2 and Flavia Prodam2; INTRODUCTION; CHILDHOOD OBESITY: PATHOLOGICAL BASIS; Genetic Considerations for Childhood Obesity; Energy Homeostasis Dysregulation; Pathophysiology of Adipose Tissue; PROTEOMICS; Gel Based Methods; Non Gel Based Methods: Mass Spectrometry (MS); Chips; Challenges; PROTEOMIC STUDIES OF ADIPOSE TISSUE; WAT Depots; WAT Secretome; BAT; Stromal-Vascular Fraction (SVF).
- PROTEOMIC STUDIES IN ADIPOCYTES: STEM CELLS AND CELL LINESAdipogenesis: Adipo-proteomics; Murine 3T3-L1 Preadipocytes; Adipocyte-Derived Stem Cells (ASCs); Adipocyte Secretome; Post-Translational Modifications (PTMs); PROTEOMIC PROFILING: TISSUES AND CIRCULATION; Fetal Programming: Tissue-Specific Biomarkers; Circulating Biomarkers; Urine Biomarkers; OUTLOOKS; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; ABBREVIATIONS; REFERENCES.
- Relationship Between Hormonal Milieu and Oxidative Stress in Childhood Obesity: A Physiopathological Basis for Antioxidant Treatment and Prevention of Cardiovascular Risk Antonio Mancini*, Francesco Leo, Chantal Di Segni, Sebastiano Raimondo and Aurora Natalia Rossodivita; INTRODUCTION; OBESITY AND OXIDATIVE STRESS; Hormones and Inflammatory Molecules Produced by or Related to Adipose Tissue; Oxidative Stress in Childhood Obesity; HORMONAL REGULATION OF ANTIOXIDANT SYSTEMS AND THEIR DERANGEMENT IN CHILDHOOD OBESITY; Growth Hormone (GH); Thyroid; Adrenal Glands; Gonads.