Anticancer therapeutics : from drug discovery to clinical applications /

An integrated presentation of the basic science and clinical applications of anticancer agents Aimed at both undergraduate and postgraduate readers, this unique text provides readers with a fully-integrated presentation of all aspects of the science of anticancer drugs, including their chemistry, ph...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores principales: Todd, Adam A., 1982- (Autor), Groundwater, Paul W. (Autor), Gill, Jason, 1973- (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Hoboken, NJ : Wiley, 2017.
Edición:First edition.
Temas:
Antineoplastic agents > Development.
Antineoplastic agents > Design.
Antineoplastic agents > Therapeutic use.
Antimitotic agents.
Antineoplastic agents.
Neoplasms > drug therapy
Neoplasms > physiopathology
Antineoplastic Agents
Drug Discovery
Antimitotic Agents
Anticancéreux > Emploi en thérapeutique.
Anticancéreux.
SCIENCE > Chemistry > Industrial & Technical.
Antineoplastic agents
Antimitotic agents
Antineoplastic agents > Design
Antineoplastic agents > Development
Antineoplastic agents > Therapeutic use
Internet Resources.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Title Page
  • Copyright Page
  • Contents
  • Preface
  • Section 1 Introduction
  • Chapter 1.1 The Global Burden of Cancer
  • References
  • Chapter 1.2 Cancer Staging and Classification
  • 1.2.1 Benign Tumour (or neoplasm)
  • 1.2.2 Malignant Tumour (or cancer)
  • 1.2.3 Tumour Nomenclature and Classification
  • 1.2.4 Cellular Differentiation and Tumour Grade
  • 1.2.5 Tumour Invasion and Metastasis
  • 1.2.6 Clinical Staging of Cancer
  • References
  • Chapter 1.3 Cellular and Molecular Basis of Cancer
  • 1.3.1 Oncogenes
  • 1.3.2 Tumour Suppressor Genes
  • 1.3.3 Role of Epigenetics and Gene Promoter Regulation in Tumourigenesis
  • 1.3.4 Multistage Tumourigenesis
  • 1.3.5 Oncogene Addiction
  • 1.3.6 Hallmarks of Cancer
  • 1.3.7 Principles of Cancer Treatment
  • References
  • Section 2 The Anticancer Agents
  • Chapter 2.1 Agents Which Act Directly on DNA
  • 2.1.1 Nitrogen Mustards and Nitrosoureas
  • References
  • 2.1.2 Temozolomide
  • References
  • 2.1.3 Platinum-containing agents
  • References
  • 2.1.4 Gemcitabine
  • References
  • 2.1.5 Camptothecin and Its Analogues
  • References
  • 2.1.6 Podophyllotoxins
  • References
  • 2.1.7 Anthracyclines [1]
  • References
  • 2.1.8 Epigenetic Targeting Agents [1]
  • References
  • Chapter 2.2 Antimetabolites
  • 2.2.1 Cytarabine
  • References
  • 2.2.2 Methotrexate
  • References
  • 2.2.3 5-Fluorouracil
  • References
  • 2.2.4 6-Mercaptopurine
  • References
  • Chapter 2.3 Antimicrotubule agents
  • 2.3.1 Taxanes
  • References
  • 2.3.2 Vinca Alkaloids
  • References
  • Chapter 2.4 Anti-hormonal agents
  • 2.4.1 Bicalutamide
  • References
  • 2.4.2 Tamoxifen
  • References
  • 2.4.3 Anastrozole [1]
  • References
  • Chapter 2.5 Kinase Inhibitors
  • 2.5.1 Discovery
  • 2.5.2 Synthesis
  • 2.5.3 Mode of Action
  • 2.5.4 Mechanism of Resistance [32]
  • 2.5.5 Adverse Drug Reactions
  • References
  • Section 3 The Cancers.
  • Chapter 3.1 Breast Cancer
  • 3.1.1 Epidemiology
  • 3.1.2 Presentation
  • 3.1.3 Diagnosis
  • 3.1.4 Staging
  • 3.1.5 Treatments
  • References
  • Chapter 3.2 Colorectal cancer
  • 3.2.1 Epidemiology
  • 3.2.2 Presentation
  • 3.2.3 Diagnosis
  • 3.2.4 Staging
  • 3.2.5 Treatments
  • References
  • Chapter 3.3 Leukaemia
  • 3.3.1 Epidemiology
  • 3.3.2 Presentation
  • 3.3.3 Diagnosis
  • 3.3.4 Staging
  • 3.3.5 Treatments
  • References
  • Chapter 3.4 Lung cancer
  • 3.4.1 Epidemiology
  • 3.4.2 Presentation
  • 3.4.3 Diagnosis
  • 3.4.4 Staging
  • 3.4.5 Treatments
  • References
  • Chapter 3.5 Oesophageal Cancer
  • 3.5.1 Epidemiology
  • 3.5.2 Presentation
  • 3.5.3 Diagnosis
  • 3.5.4 Staging
  • 3.5.5 Treatments
  • References
  • Chapter 3.6 Ovarian cancer
  • Key points
  • 3.6.1 Epidemiology
  • 3.6.2 Presentation
  • 3.6.3 Diagnosis
  • 3.6.4 Staging
  • 3.6.5 Treatments
  • References
  • Chapter 3.7 Pancreatic Cancer
  • 3.7.1 Epidemiology
  • 3.7.2 Presentation
  • 3.7.3 Diagnosis
  • 3.7.4 Staging
  • 3.7.5 Treatments
  • References
  • Chapter 3.8 Prostate Cancer
  • 3.8.1 Epidemiology
  • 3.8.2 Presentation
  • 3.8.3 Diagnosis
  • 3.8.4 Staging
  • 3.8.5 Treatments
  • References
  • Chapter 3.9 Skin Cancers
  • 3.9.1 Epidemiology
  • 3.9.2 Presentation
  • 3.9.3 Diagnosis
  • 3.9.4 Staging
  • 3.9.5 Treatments
  • References
  • Chapter 3.10 Testicular cancer
  • 3.10.1 Epidemiology
  • 3.10.2 Presentation
  • 3.10.3 Diagnosis
  • 3.10.4 Staging
  • 3.10.5 Treatments
  • References
  • Index
  • EULA.

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