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Nutrigenomics and proteomics in health and disease : towards a systems-level understanding of gene-diet interactions /
"This volume brings together leading experts in the areas of nutrition, nutrigenomics, metabolic programming, food-based bioactive dietary components and the gut microbiome, as well as those expert in the application of innovative tools and methods for statistical and biological network analysi...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Chichester, West Sussex :
John Wiley & Sons, Inc.,
[2017]
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| Edición: | Second edition. |
| Colección: | Functional food science and technology series.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Title Page ; Copyright Page; Contents; Contributors; Preface; Biography of Martin Kussmann; Section I Genes, Proteins, and Nutrition ; Chapter 1 The use of transcriptomics as a tool to identify differences in the response to diet; 1.1 New concepts in nutrition research; 1.2 Comprehensive phenotyping; 1.3 Phenotypic flexibility; 1.4 Factors that influence the transcriptome response to diet; 1.5 Using transcriptomics to explain the mechanism behind differences in response to diet; 1.6 Conclusion; 1.7 Future perspectives; References.
- Chapter 2 Genetic or nutritional disturbances in folate-related pathways and epigenetic interactions 2.1 Introduction; 2.2 Nutrition and one-carbon metabolism ; 2.3 Importance of DNA?methylation at CpG dinucleotides; 2.4 Folate-dependent disorders: Dietary impact ; 2.5 Genetic influences on phenotype and interactions with epigenetics; 2.6 Epigenetic inheritance across generations; 2.7 Conclusions; References; Chapter 3 Early-life development and epigenetic mechanisms: Mediators of metabolic programming and obesity risk ; 3.1 Introduction; 3.2 Origins of DOHaD and its conceptual basis.
- 3.3 Epigenetic mechanisms3.4 Early-life nutrition, epigenetics, and metabolic programming ; 3.5 Paternal effects; 3.6 Transgenerational epigenetic inheritance; 3.7 The potential value of DOHaD principles and epigenetic biology to the improvement of human health; 3.8 Conclusion; Acknowledgments; References; Section II Bioactives and Phytonutrients ; Chapter 4 Bioactive interactions in food and natural extracts; 4.1 Natural compounds as all compounds produced by nature; 4.2 Not all natural compounds are created active; 4.3 On the road of modern technologies for bioactive discovery.
- 4.4 Metabolomics strategies applied to bioactives biochemistry4.5 Bioactives as multi?target network instigators; 4.6 'Let food be thy medicine and medicine be thy food'
- outlook; Acknowledgments; References; Chapter 5 Anthocyanins in metabolic health and disease; 5.1 Introduction; 5.2 Chemical structure; 5.3 Structural effects on stability; 5.4 Systemic bioavailability and tissue distribution; 5.5 Metabolism and nutrigenomic effects; 5.6 Conclusions; Acknowledgments; References; Chapter 6 Dietary antioxidants and bioflavonoids in atherosclerosis and angiogenesis; 6.1 Introduction.
- 6.2 Dietary vitamins E and C and CVD6.3 Dietary polyphenols and CVD; 6.4 Flavonoids and angiogenesis; 6.5 Conclusion; Acknowledgments; References; Chapter 7 Genomics and proteomics approaches to identify resveratrol targets in cancer; 7.1 Introduction; 7.2 Sources and health benefits of resveratrol; 7.3 Resveratrol for cancer prevention and therapy; 7.4 Functional genomics approaches to identify resveratrol targets in cancer; 7.5 Proteomics approaches to identify resveratrol targets in cancer; 7.6 Metabolomics approaches to identify pathways modified by resveratrol in cancer.