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Solid state properties of pharmaceutical materials /
Presents a detailed discussion of important solid-state properties, methods, and applications of solid-state analysis -Illustrates the various phases or forms that solids can assume and discussesvarious issues related to the relative stability of solid forms and tendencies to undergo transformation...
| Clasificación: | Libro Electrónico |
|---|---|
| Autores principales: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken, NJ :
Wiley,
2017.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Solid-State Properties of Pharmaceutical Materials; Contents; Preface; Acknowledgments; 1 Solid-State Properties and Pharmaceutical Development; 1.1 Introduction; 1.2 Solid-State Forms; 1.3 ICH Q6A Decision Trees; 1.4 "Big Questions" for Drug Development; 1.5 Accelerating Drug Development; 1.6 Solid-State Chemistry in Preformulation and Formulation; 1.7 Learning Before Doing and Quality by Design; 1.8 Performance and Stability in Pharmaceutical Development; 1.9 Moisture Uptake; 1.10 Solid-State Reactions; 1.11 Noninteracting Formulations: Physical Characterizations; References; 2 Polymorphs.
- 2.1 Introduction2.2 How Are Polymorphs Formed?; 2.3 Structural Aspect of Polymorphs; 2.3.1 Configurational Polymorphs; 2.3.2 Conformational Polymorphs; 2.4 Physical, Chemical, and Mechanical Properties; 2.4.1 Solubility; 2.4.2 Chemical Stability; 2.4.3 Mechanical Properties; 2.5 Thermodynamic Stability of Polymorphs; 2.5.1 Monotropy and Enantiotropy; 2.5.2 Burger and Rambergers Rules; 2.5.3 vant Hoff Plot; 2.5.4 DG/Temperature Diagram; 2.6 Polymorph Conversion; 2.6.1 Solution-Mediated Transformation; 2.6.2 Solid-State Conversion; 2.7 Control of Polymorphs; 2.8 Polymorph Screening.
- 2.9 Polymorph PredictionReferences; 3 Solvates and Hydrates; 3.1 Introduction; 3.2 Pharmaceutical Importance of Hydrates; 3.3 Classification of Pharmaceutical Hydrates; 3.4 Water Activity; 3.5 Stoichiometric Hydrates; 3.6 Nonstoichiometric Hydrates; 3.7 Hydration/Dehydration; 3.8 Preparation and Characterization of Hydrates and Solvates; References; 4 Pharmaceutical Salts; 4.1 Introduction; 4.2 Importance of Pharmaceutical Salts; 4.3 Weak Acid, Weak Base, and Salt; 4.4 pH-Solubility Profiles of Ionizable Compounds; 4.5 Solubility, Dissolution, and Bioavailability of Pharmaceutical Salts.
- 4.6 Physical Stability of Pharmaceutical Salts4.7 Strategies for Salt Selection; References; 5 Pharmaceutical Cocrystals; 5.1 Introduction; 5.2 Cocrystals and Crystal Engineering; 5.3 Solubility Phase Diagrams For Cocrystals; 5.4 Preparation of Cocrystals; 5.5 Dissolution and Bioavailability of Cocrystals; 5.6 Comparison of Pharmaceutical Salts and Cocrystals; References; 6 Amorphous Solids; 6.1 Introduction; 6.2 The Formation of Amorphous Solids; 6.3 Methods of Preparing Amorphous Solids; 6.4 The Glass Transition Temperature; 6.5 Structural Features of Amorphous Solids.
- 6.6 Molecular Mobility6.6.1 Overview of Molecular Mobility; 6.6.2 Viscosity and Molecular Mobility; 6.6.3 Relaxation Time; 6.6.4 Fragility in Supercooled Liquids; 6.6.5 Diffusive Relaxation Time in the Glassy State; 6.6.6 Secondary Relaxations in Amorphous Solids; 6.7 Mixtures of Amorphous Solids; 6.7.1 Overview; 6.7.2 Thermodynamics of Molecular Mixing in Amorphous Solids; 6.7.3 The Glass Transition Temperature and Molecular Mobility of Miscible Amorphous Mixtures; References; 7 Crystal Mesophases and Nanocrystals; 7.1 Introduction; 7.2 Overview of Crystal Mesophases; 7.3 Liquid Crystals.