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|a UAMI
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|a Process scale purification of antibodies /
|c edited by Uwe Gottschalk.
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| 250 |
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|a Second edition.
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| 264 |
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1 |
|a Hoboken, NJ :
|b Wiley,
|c 2017.
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| 300 |
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|a 1 online resource
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| 336 |
|
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 504 |
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|a Includes bibliographical references and index.
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| 588 |
0 |
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|a Print version record and CIP data provided by publisher.
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| 505 |
0 |
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|a TITLE PAGE ; COPYRIGHT PAGE ; CONTENTS; PREFACE ; LIST OF CONTRIBUTORS; CHAPTER 1 DOWNSTREAM PROCESSING OF MONOCLONAL ANTIBODIES: CURRENT PRACTICES AND FUTURE OPPORTUNITIES; 1.1 INTRODUCTION; 1.2 A BRIEF HISTORY OF CURRENT GOOD MANUFACTURING PROCESS mAb AND INTRAVENOUS IMMUNOGLOBULIN PURIFICATION; 1.3 CURRENT APPROACHES IN PURIFICATION PROCESS DEVELOPMENT: IMPACT OF PLATFORM PROCESSES; 1.4 TYPICAL UNIT OPERATIONS AND PROCESSING ALTERNATIVES; 1.5 VLS PROCESSES: TON-SCALE PRODUCTION AND BEYOND ; 1.6 PROCESS VALIDATION; 1.7 PRODUCT LIFE CYCLE MANAGEMENT; 1.8 FUTURE OPPORTUNITIES; 1.9 CONCLUSIONS.
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| 505 |
8 |
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|a ACKNOWLEDGMENTSREFERENCES; CHAPTER 2 THE DEVELOPMENT OF ANTIBODY PURIFICATION TECHNOLOGIES; 2.1 INTRODUCTION; 2.2 PURIFICATION OF ANTIBODIES BY CHROMATOGRAPHY BEFORE PROTEIN A; 2.3 ANTIBODY PURIFICATION AFTER 1975; 2.4 ADDITIONAL TECHNOLOGIES FOR ANTIBODY PURIFICATION; 2.5 PURIFICATION OF mAbs APPROVED IN NORTH AMERICA AND EUROPE; 2.6 CURRENT ANTIBODY PROCESS TECHNOLOGY DEVELOPMENTS; ACKNOWLEDGMENTS; REFERENCES; CHAPTER 3 HARVEST AND RECOVERY OF MONOCLONAL ANTIBODIES: CELL REMOVAL AND CLARIFICATION; 3.1 INTRODUCTION; 3.2 CENTRIFUGATION; 3.3 MICROFILTRATION; 3.4 DEPTH FILTRATION.
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| 505 |
8 |
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|a 3.5 FLOCCULATION3.6 ABSOLUTE FILTRATION; 3.7 EXPANDED BED ADSORPTION CHROMATOGRAPHY; 3.8 HARVESTING IN SINGLE?USE MANUFACTURING; 3.9 COMPARISON OF HARVEST AND CLARIFICATION UNIT OPERATIONS; REFERENCES; CHAPTER 4 NEXT-GENERATION CLARIFICATION TECHNOLOGIES FOR THE DOWNSTREAM PROCESSING OF ANTIBODIES ; 4.1 INTRODUCTION; 4.2 IMPURITY PROFILES IN CELL CULTURES; 4.3 PRECIPITATION; 4.3.1 Acid Precipitation; 4.3.2 Caprylic Acid Precipitation; 4.3.3 PEG Precipitation; 4.3.4 Cold Ethanol Precipitation; 4.4 AFFINITY PRECIPITATION; 4.5 FLOCCULATION; 4.5.1 Anionic Flocculation; 4.5.2 Cationic Flocculation.
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| 505 |
8 |
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|a 4.5.3 Multimodal Flocculation4.6 TOXICITY OF FLOCCULANTS AND PRECIPITANTS AND THEIR RESIDUAL CLEARANCE; 4.7 DEPTH FILTRATION; 4.7.1 Improvements in Depth Filtration Technology; 4.7.2 Impurity Removal by Depth Filtration; 4.7.3 Virus Clearance by Depth Filtration; 4.8 CONSIDERATIONS FOR THE IMPLEMENTATION OF NEW CLARIFICATION TECHNOLOGIES; 4.9 CONCLUSIONS AND FUTURE PERSPECTIVES; ACKNOWLEDGMENTS; REFERENCES; CHAPTER 5 PROTEIN A-BASED AFFINITY CHROMATOGRAPHY ; 5.1 INTRODUCTION; 5.2 PROPERTIES OF PROTEIN A AND COMMERCIALLY AVAILABLE PROTEIN A RESINS; 5.2.1 Protein A Structure.
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| 505 |
8 |
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|a 5.2.2 Protein A-Immunoglobulin G Interaction5.2.3 Stoichiometry of Protein A-IgG Binding; 5.2.4 Protein A Stability; 5.2.5 Commercial Protein A Resins; 5.2.6 Static Capacity; 5.2.7 Dynamic Binding Capacity; 5.2.8 Leaching; 5.2.9 Production Rates; 5.3 PROTEIN A CHROMATOGRAPHY STEP DEVELOPMENT; 5.3.1 Loading/Binding; 5.3.2 Wash Development; 5.3.3 Elution; 5.3.4 Stripping; 5.3.5 Regeneration and CIP; 5.4 ADDITIONAL CONSIDERATIONS DURING DEVELOPMENT AND SCALE?UP; 5.4.1 Controlling HMW Aggregate Formation; 5.4.2 Removal of Soluble HMW Contaminants; 5.4.3 Turbidity; 5.5 VIRUS REMOVAL/INACTIVATION.
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| 590 |
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|a ProQuest Ebook Central
|b Ebook Central Academic Complete
|
| 650 |
|
0 |
|a Monoclonal antibodies
|x Purification.
|
| 650 |
|
0 |
|a Biochemical engineering.
|
| 650 |
1 |
2 |
|a Antibodies, Monoclonal
|x isolation & purification
|
| 650 |
2 |
2 |
|a Antibodies, Monoclonal
|x therapeutic use
|
| 650 |
2 |
2 |
|a Chromatography
|x methods
|
| 650 |
2 |
2 |
|a Technology, Pharmaceutical
|x methods
|
| 650 |
|
6 |
|a Génie biochimique.
|
| 650 |
|
7 |
|a MEDICAL
|x Pharmacology.
|2 bisacsh
|
| 650 |
|
7 |
|a Biochemical engineering
|2 fast
|
| 655 |
|
4 |
|a Internet Resources.
|
| 700 |
1 |
|
|a Gottschalk, Uwe,
|e editor.
|
| 758 |
|
|
|i has work:
|a Process scale purification of antibodies (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCFGvmhJtjKMJd9MwG3Dqry
|4 https://id.oclc.org/worldcat/ontology/hasWork
|
| 776 |
0 |
8 |
|i Print version:
|t Process scale purification of antibodies.
|b Second edition.
|d Hoboken, NJ : John Wiley & Sons Inc., 2017
|z 9781119126911
|w (DLC) 2017005408
|
| 856 |
4 |
0 |
|u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=4818687
|z Texto completo
|
| 938 |
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|a Askews and Holts Library Services
|b ASKH
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|a EBSCOhost
|b EBSC
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|b IDEB
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