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Interpretation of MS-MS Mass Spectra of Drugs and Pesticides.
Provides comprehensive coverage of the interpretation of LC-MS-MS mass spectra of 1300 drugs and pesticides -Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes -This is the reference book for th...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Somerset :
John Wiley & Sons, Incorporated,
2017.
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| Colección: | Wiley-Interscience series on mass spectrometry.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover; Title Page; Copyright; Contents; Preface; Abbreviations; Chapter 1 Introduction to LC-MS Technology; 1.1 Introduction; 1.2 Analyte Ionization: Ion Sources; 1.2.1 Electron Ionization; 1.2.2 Chemical Ionization; 1.2.3 Atmospheric-Pressure Ionization; 1.2.4 Electrospray Ionization; 1.2.5 Atmospheric-Pressure Chemical Ionization and Photoionization; 1.2.6 Other Ionization Techniques; 1.3 Mass Spectrometer Building Blocks; 1.3.1 Introduction; 1.3.2 Quadrupole Mass Analyzer; 1.3.3 Ion-Trap Mass Analyzer; 1.3.4 Time-of-Flight Mass Analyzer; 1.3.5 Orbitrap Mass Analyzer.
- 1.3.6 Other Mass Analyzers1.4 Tandem Mass Spectrometry; 1.4.1 Introduction; 1.4.2 Tandem Quadrupole Instruments; 1.4.3 Ion-Trap Instruments; 1.4.4 Quadrupole-Linear Ion-Trap Hybrid Instruments; 1.4.5 Quadrupole-Time-of-Flight Hybrid Instruments; 1.4.6 Orbitrap Hybrid Instruments for MS-MS and MSn; 1.4.7 Other Instruments for MS-MS and MSn; 1.4.8 MS-MS and MSn in the Analysis of Drugs and Pesticides; 1.5 Data Acquisition; 1.5.1 Introduction; 1.5.2 Selected-Ion and Selected-Reaction Monitoring; 1.5.3 Structure-Specific Screening: Precursor-Ion and Neutral-Loss Analysis.
- 1.5.4 Data-Dependent Acquisition1.5.5 Data-Independent Acquisition; 1.6 Selected Literature on Mass Spectrometry; References; Chapter 2 Interpretation of Mass Spectra; 2.1 Mass Spectrometry: A Nuclear Affair; 2.2 Isomers, Isotones, Isobars, Isotopes; 2.3 Masses in MS; 2.4 Isotopes and Structure Elucidation; 2.5 Nitrogen Rule, Ring Double-Bond Equivalent, and Hydrogen Rule; 2.6 Resolving Power, Resolution, Accuracy; 2.7 Calculating Elemental Composition from Accurate m/z; 2.8 Protonated and Deprotonated Molecules and Adduct Ions; References; Chapter 3 Fragmentation of Even-Electron Ions.
- 3.1 Introduction3.2 Analyte Ionization Revisited; 3.3 Fragmentation of Odd-electron Ions; 3.4 High-energy Collisions of Protonated Molecules; 3.4.1 General Aspects; 3.4.2 Selected Examples; 3.5 Fragmentation of Protonated Molecules; 3.5.1 Singly-Charged Peptides; 3.5.2 Protonated Small Molecules: Complementary Fragment Ions; 3.5.3 Fragmentation of Peptides Revisited; 3.5.4 Direct-Cleavage Reactions; 3.5.5 Consecutive Small-Molecule Losses; 3.5.6 Other Fragmentation Reactions; 3.5.7 Loss of Radicals from Even-Electron Ions; 3.5.8 Skeletal Rearrangements in Protonated Molecules.
- 3.6 Characteristic Positive-ion Fragmentation of Functional Groups3.6.1 Cleavages of C-C Bonds; 3.6.2 Alcohols and Ethers; 3.6.3 Aldehydes and Ketones; 3.6.4 Carboxylic Acids and Esters; 3.6.5 Amines and Quaternary Ammonium Compounds; 3.6.6 Amides, Sulfonyl Ureas, and Carbamates; 3.6.7 Compounds Containing Phosphorus or Sulfur; 3.6.8 Miscellaneous Compound Classes; 3.7 Fragmentation of Deprotonated Molecules; 3.7.1 High-Energy CID with NICI-Generated Deprotonated Molecules; 3.7.2 General Aspects; 3.7.3 Alcohols and Ethers; 3.7.4 Carboxylic Acid and Esters; 3.7.5 Amines; 3.7.6 Amides and Ureas.