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Keratoconus : recent advances in diagnosis and treatment /
As a degenerative disorder of the eye, keratoconus can cause substantial distortion of vision, with multiple images, streaking, and sensitivity to light all reported by patients. Keratoconus: Recent Advances in Diagnosis and Treatment updates ophthalmologists about the innovations that have occurred...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cham, Switzerland :
Springer,
2017.
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| Colección: | Essentials in ophthalmology.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Foreword; Preface; Contents; Contributors; Part I: Introduction; 1: What Is Keratoconus? AÈNew Approach toäÈNot SoÈRare Disease; References; 2: Modern Pathogenesis ofÈKeratoconus: Genomics andÈProteomics; 2.1 Introduction; 2.2 Candidate-Driven Approach; 2.2.1 Candidate Gene Approach; 2.2.2 Syndromic Keratoconus; 2.2.3 Non-candidate-Driven Approach; 2.2.4 Linkage Analysis; 2.2.5 Genome-wide Association Studies; 2.2.6 Transcriptomics-Proteomics; 2.3 Conclusion; References; 3: Epidemiology ofÈKeratoconus; 3.1 Introduction; 3.2 Incidence andÈPrevalence.
- 3.3 Environmental andÈGenetic Factors: Separate or Synergistic?3.4 Ultraviolet Light Exposure; 3.5 Eye Rubbing andÄllergy; 3.6 Gender; 3.7 Age; 3.8 Associations withÖther Diseases; 3.8.1 Down Syndrome; 3.8.2 Leber's Congenital Amaurosis; 3.8.3 Connective Tissue Disorders; 3.9 Discussion; References; 4: Histopathology (from Keratoconus Pathology to Pathogenesis); 4.1 Introduction; 4.2 Signs ofÈKeratoconus: Clinical vs. Pathological; 4.3 Structural Changes inÈKeratoconus; 4.3.1 Bowman's Layer; 4.3.2 Stroma-Collagen Lamellae; 4.3.3 Descemet's Membrane.
- 4.3.4 Matrix Deposition andÈScar Formation4.4 Cellular Changes inÈKeratoconus; 4.4.1 Epithelium; 4.4.2 Cellular Incursion intoÈBowman's Layer; 4.4.3 Stroma; 4.4.4 Endothelium; 4.5 Keratoconic Changes inÈSecreted Enzymatic Factors; 4.5.1 Matrix metalloproteinases; 4.5.2 Matrix metalloproteinases Tissue Inhibitors; 4.5.3 Cathepsins; 4.6 Recurrence ofÈPathology; 4.7 A Role forÏnflammation inÈKeratoconus; 4.7.1 Immunohistochemical Evidence ofÏnflammation; 4.8 Pathology Informing Pathogenesis; References; 5: Keratoconus inÈChildren; 5.1 Treatment; References.
- Part II: Diagnostic Tools in Keratoconus6: Instrumentation forÈDiagnosis ofÈKeratoconus; 6.1 Videokeratoscopes; 6.2 The Sagittal Curvature; 6.3 The Tangential Curvature; 6.4 The Height Maps; 6.5 Arc Step; 6.6 Optical Scanning Devices; 6.7 Corneal Thickness; 6.8 Scheimpflug Camera; 6.9 AS-OCT (Anterior Segment Optical Coherence Tomography) [13]; 6.10 Brief Introduction toÄutomated Systems forÈKeratoconus Screening; 6.10.1 Objective Parameters forÈQuantifying theËctasia; 6.11 Modern Hybrid Systems Based Assisted Learning; References.
- 7: Analyzing Tomographic Corneal Elevation forÈDetecting Ectasia7.1 Introduction; 7.2 Background; 7.3 How Elevation Is Displayed; 7.4 Enhanced Reference Surface; References; 8: Analyzing Tomographic Thickness forÈDetecting Corneal Ectatic Diseases; 8.1 Introduction; 8.2 Tomographic Corneal Thickness Assessment; 8.3 The Corneal Thickness Spatial Profile (CSTP) andẗheÈPercentage Thickness Increase (PTI) Graphs; 8.4 The AmbrĐosio Relational Thickness Variables; 8.5 Single-Point Pachymetry vs. Tomography-Derived Pachymetric Variables forÈDiagnosing Keratoconus.