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Wiley IUBMB : Recent Advances in Malaria.
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Somerset :
John Wiley & Sons, Incorporated,
2016.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Title Page ; Copyright Page; Contents; List ofÈcontributors; Foreword; Preface; Chapter 1 Introduction: An overview of malaria and Plasmodium ; History; The life cycle ofÈPlasmodium; A significant milestone inÈmalaria research: Adaptation ofÈPlasmodium toÈlaboratory culture; The advent of present-day technologies and their applications in malaria research ; Bibliography; Chapter 2 Exoerythrocytic development ofÈPlasmodiumÈparasites; The sporozoite's journey fromẗheÈskin toẗheÈliver; Sporozoite invasion; Parasite development; Protein export fromẗheÈparasite into theḧost cell.
- Parasite egressThe role ofïnnate immune responses during merosome formation; Acknowledgments; Bibliography; Chapter 3 Molecular basis of erythrocyte invasion by Plasmodium merozoites ; The structure ofẗheÈmerozoite; The steps ofërythrocyte invasion; Step 1: Initial attachment ofẗheÈmerozoite toẗheërythrocyte surface; Step 2: Apical reorientation; Step 3: Formation ofẗheÈjunction; Redundancy andÈligand-receptor interactions that mediate parasiteädhesion during erythrocyte invasion; Duffy binding-like family; Reticulocyte binding-like (RBL) family.
- Cooperativity between theÈDBL andÈRBL families ofÈproteinsIdentification ofÈnovel parasite ligands; Signaling events during erythrocyte invasion by malaria parasites; Summary andÈconclusions; Bibliography; Chapter 4 The biology ofÈmalaria transmission; Purpose; History; The current research agenda; Biology; Parasite; Vector; Vertebrate host; Population dynamics; Parasite dynamics inẗheÈmosquito; Transmission-blocking interventions ; Anti-vector strategies ; Anti-parasitic transmission-blocking interventions ; Bibliography; Chapter 5 Comparative and functional genomics of malaria parasites.
- An Introduction toÈPlasmodium genomesGenome structure ofÈmalaria parasites; Base content; Genome size andÈcomposition; Chromosome structure; Lineage-specific gene families ; From genome sequences toÈgene function; Genetic mapping; Population genomics toïdentify vaccine or drug targets; Global analysis ofẗranscripts; Epigenomics; Reverse genetics andÈparasite transformation; Summary; Acknowledgments; Bibliography; Chapter 6 Gene regulation: New insights and possible intervention strategies ; Introduction; Modes ofÈgene regulation; Epigenetic mechanisms ofÈgene regulation.
- Transcription factors and other DNA-binding proteins Alternative splicing; Post-transcriptional, translational, and post-translational gene regulation ; Drug targeting; Histone acetyltransferases (HATs); Histone deacetylases (HDACs); Histone methyltransferases; Histone demethylases; Histone kinases; Histone post-translational modification readers ; DNA methyltransferases; Perspectives; Bibliography; Chapter 7 Molecular genetic approaches to malaria research ; Transfection methods; Transient transfection; Stable transfection; Bxb1 integrase system; Genetic approaches forÈderiving gene function.