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Oral bioavailability assessment : basics and strategies for drug discovery and development /
Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability - one of the most significant hurdles in drug discovery and development.- Describes approaches to assess pharmacokinetics and how drug efflux and...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken, NJ :
John Wiley & Sons Inc.,
2017.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Drug pharmacokinetics and toxicokinetics
- GIT anatomy and physiology and drug oral bioavailability : impact of species differences
- Drug routes of excretion
- Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion
- Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect
- Impact of intestinal efflux transporters on oral absorption
- Impact of influx transporters on drug
- Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery
- In vitro and in situ approaches to measure intestinal permeability and efflux transporters
- In silico approaches to predict intestinal permeability
- In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption
- In vitro approaches to assess haptic metabolism and first pass effect
- The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective.