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Oral bioavailability assessment : basics and strategies for drug discovery and development /

Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability - one of the most significant hurdles in drug discovery and development.- Describes approaches to assess pharmacokinetics and how drug efflux and...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: El-Kattan, Ayman F. (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Hoboken, NJ : John Wiley & Sons Inc., 2017.
Temas:
Acceso en línea:Texto completo

MARC

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100 1 |a El-Kattan, Ayman F.,  |e author. 
245 1 0 |a Oral bioavailability assessment :  |b basics and strategies for drug discovery and development /  |c Ayman F. El-Kattan. 
264 1 |a Hoboken, NJ :  |b John Wiley & Sons Inc.,  |c 2017. 
300 |a 1 online resource 
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337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
504 |a Includes bibliographical references and index. 
505 0 |a Drug pharmacokinetics and toxicokinetics -- GIT anatomy and physiology and drug oral bioavailability : impact of species differences -- Drug routes of excretion -- Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion -- Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect -- Impact of intestinal efflux transporters on oral absorption -- Impact of influx transporters on drug -- Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery -- In vitro and in situ approaches to measure intestinal permeability and efflux transporters -- In silico approaches to predict intestinal permeability -- In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption -- In vitro approaches to assess haptic metabolism and first pass effect -- The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective. 
588 0 |a Print version record and CIP data provided by publisher. 
520 |a Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability - one of the most significant hurdles in drug discovery and development.- Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability- Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development- Explains how preclinical animal models - used in preclinical testing - and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development- Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)- Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development. 
590 |a ProQuest Ebook Central  |b Ebook Central Academic Complete 
650 0 |a Dental pharmacology. 
650 0 |a Bioavailability. 
650 0 |a Oral medication. 
650 1 2 |a Biological Availability 
650 2 2 |a Administration, Oral 
650 2 2 |a Drug Evaluation, Preclinical 
650 2 2 |a Toxicokinetics 
650 6 |a Pharmacologie dentaire. 
650 6 |a Biodisponibilité. 
650 6 |a Médicaments  |x Administration par voie orale. 
650 7 |a MEDICAL  |x Pharmacology.  |2 bisacsh 
650 7 |a Oral medication  |2 fast 
650 7 |a Bioavailability  |2 fast 
650 7 |a Dental pharmacology  |2 fast 
655 4 |a Fulltext. 
655 4 |a Internet Resources. 
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