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Oral bioavailability assessment : basics and strategies for drug discovery and development /
Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability - one of the most significant hurdles in drug discovery and development.- Describes approaches to assess pharmacokinetics and how drug efflux and...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken, NJ :
John Wiley & Sons Inc.,
2017.
|
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 100 | 1 | |a El-Kattan, Ayman F., |e author. | |
| 245 | 1 | 0 | |a Oral bioavailability assessment : |b basics and strategies for drug discovery and development / |c Ayman F. El-Kattan. |
| 264 | 1 | |a Hoboken, NJ : |b John Wiley & Sons Inc., |c 2017. | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Drug pharmacokinetics and toxicokinetics -- GIT anatomy and physiology and drug oral bioavailability : impact of species differences -- Drug routes of excretion -- Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion -- Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect -- Impact of intestinal efflux transporters on oral absorption -- Impact of influx transporters on drug -- Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery -- In vitro and in situ approaches to measure intestinal permeability and efflux transporters -- In silico approaches to predict intestinal permeability -- In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption -- In vitro approaches to assess haptic metabolism and first pass effect -- The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective. | |
| 588 | 0 | |a Print version record and CIP data provided by publisher. | |
| 520 | |a Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability - one of the most significant hurdles in drug discovery and development.- Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability- Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development- Explains how preclinical animal models - used in preclinical testing - and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development- Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)- Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development. | ||
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Dental pharmacology. | |
| 650 | 0 | |a Bioavailability. | |
| 650 | 0 | |a Oral medication. | |
| 650 | 1 | 2 | |a Biological Availability |
| 650 | 2 | 2 | |a Administration, Oral |
| 650 | 2 | 2 | |a Drug Evaluation, Preclinical |
| 650 | 2 | 2 | |a Toxicokinetics |
| 650 | 6 | |a Pharmacologie dentaire. | |
| 650 | 6 | |a Biodisponibilité. | |
| 650 | 6 | |a Médicaments |x Administration par voie orale. | |
| 650 | 7 | |a MEDICAL |x Pharmacology. |2 bisacsh | |
| 650 | 7 | |a Oral medication |2 fast | |
| 650 | 7 | |a Bioavailability |2 fast | |
| 650 | 7 | |a Dental pharmacology |2 fast | |
| 655 | 4 | |a Fulltext. | |
| 655 | 4 | |a Internet Resources. | |
| 758 | |i has work: |a Oral Bioavailability Assessment (Text) |1 https://id.oclc.org/worldcat/entity/E39PCY8x33vyqdy8YmBJYGv9J8 |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
| 776 | 0 | 8 | |i Print version: |a El-Kattan, Ayman F. |t Oral bioavailability assessment. |d Hoboken, NJ : John Wiley & Sons Inc., 2017 |z 9781118916698 |w (DLC) 2016055388 |w (OCoLC)965446613 |
| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=4862949 |z Texto completo |
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