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|a UAMI
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1 |
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|a El-Kattan, Ayman F.,
|e author.
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245 |
1 |
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|a Oral bioavailability assessment :
|b basics and strategies for drug discovery and development /
|c Ayman F. El-Kattan.
|
264 |
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1 |
|a Hoboken, NJ :
|b John Wiley & Sons Inc.,
|c 2017.
|
300 |
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|a 1 online resource
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336 |
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|a text
|b txt
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|a computer
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504 |
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|a Includes bibliographical references and index.
|
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|a Drug pharmacokinetics and toxicokinetics -- GIT anatomy and physiology and drug oral bioavailability : impact of species differences -- Drug routes of excretion -- Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion -- Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect -- Impact of intestinal efflux transporters on oral absorption -- Impact of influx transporters on drug -- Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery -- In vitro and in situ approaches to measure intestinal permeability and efflux transporters -- In silico approaches to predict intestinal permeability -- In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption -- In vitro approaches to assess haptic metabolism and first pass effect -- The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective.
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588 |
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|a Print version record and CIP data provided by publisher.
|
520 |
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|a Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability - one of the most significant hurdles in drug discovery and development.- Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability- Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development- Explains how preclinical animal models - used in preclinical testing - and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development- Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)- Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development.
|
590 |
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|a ProQuest Ebook Central
|b Ebook Central Academic Complete
|
650 |
|
0 |
|a Dental pharmacology.
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650 |
|
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|a Bioavailability.
|
650 |
|
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|a Oral medication.
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650 |
1 |
2 |
|a Biological Availability
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650 |
2 |
2 |
|a Administration, Oral
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650 |
2 |
2 |
|a Drug Evaluation, Preclinical
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650 |
2 |
2 |
|a Toxicokinetics
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650 |
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6 |
|a Pharmacologie dentaire.
|
650 |
|
6 |
|a Biodisponibilité.
|
650 |
|
6 |
|a Médicaments
|x Administration par voie orale.
|
650 |
|
7 |
|a MEDICAL
|x Pharmacology.
|2 bisacsh
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|
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|a Dental pharmacology
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|
655 |
|
4 |
|a Fulltext.
|
655 |
|
4 |
|a Internet Resources.
|
758 |
|
|
|i has work:
|a Oral Bioavailability Assessment (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCY8x33vyqdy8YmBJYGv9J8
|4 https://id.oclc.org/worldcat/ontology/hasWork
|
776 |
0 |
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|i Print version:
|a El-Kattan, Ayman F.
|t Oral bioavailability assessment.
|d Hoboken, NJ : John Wiley & Sons Inc., 2017
|z 9781118916698
|w (DLC) 2016055388
|w (OCoLC)965446613
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