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Chemical Analysis of Non-Antimicrobial Veterinary Drug Residues in Food.
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Somerset :
John Wiley & Sons, Incorporated,
2016.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover; Title Page; Copyright; Dedication; Contents; Preface; List of Contributors; About the Editors; Chapter 1 Basic Considerations for the Analyst for Veterinary Drug Residue Analysis in Animal Tissues; 1.1 Introduction; 1.2 Pharmacokinetics; 1.3 Metabolism and Distribution; 1.4 Choice of Analytical Method; 1.5 Importance of Regulatory Limits; 1.5.1 Derivation of the Acceptable Daily Intake; 1.5.2 Derivation of the Acute Reference Dose; 1.5.3 Derivation of Maximum Residue Limits; 1.5.4 Derivation of Tolerances; 1.6 International Obligations for Regulatory Analytical Laboratories.
- 1.6.1 Laboratory Accreditation1.6.2 Validation of Analytical Methods; 1.6.3 Consistent Use of Terminology; 1.6.4 Sample Handling and Retention; 1.6.5 Confirmatory Analysis; 1.6.6 Quality Assurance Measures; 1.6.7 Proficiency Testing; 1.6.8 Reporting of Results; 1.7 Conclusions; References; Chapter 2 Emerging Techniques in Sample Extraction and Rapid Analysis; 2.1 Introduction; 2.2 Sample Extraction; 2.2.1 Solvent Extraction and Protein Precipitation; 2.2.2 Phase Separation by Salt-Induced Partitioning; 2.2.3 Phase Separation by Low-Temperature Partitioning.
- 2.2.4 Physical Separation by ultra-filtration2.2.5 Sample Extraction with Green Chemistry Techniques; 2.3 Extract Clean-up with Solid-Phase Sorbents; 2.3.1 Solid-Phase Extraction Formats; 2.3.2 Solid-Phase Sorbent Chemistry; 2.4 Micro-extraction Techniques for Solvent and Sorbent Extraction; 2.4.1 Solvent Micro-extraction; 2.4.2 Sorbent Micro-extraction; 2.5 Emerging Techniques in Liquid Chromatography; 2.5.1 Ultrahigh Performance Liquid Chromatography; 2.5.2 Core-Shell Columns; 2.5.3 Hydrophilic Interaction Liquid Chromatography; 2.5.4 Other Emerging LC Techniques.
- 2.6 Direct Mass Spectrometry Analysis of Sample Extracts2.6.1 Flow Injection Mass Spectrometry; 2.6.2 Direct Desorption/Ionization Mass Spectrometry; 2.6.3 Direct MS Considerations for Regulatory Analysis; 2.7 Ion Mobility Spectrometry; 2.8 Conclusions; References; Chapter 3 Capabilities and Limitations of High-Resolution Mass Spectrometry (HRMS): time-of-flight and OrbitrapTM; 3.1 Available Technology; 3.1.1 TOF; 3.1.2 OrbitrapTM; 3.2 Capabilities and Limitations of the Technology as Compared to LC-MS/MS (Tandem Quadrupole Mass Spectrometer); 3.2.1 Selectivity; 3.2.2 Quantification.
- 3.2.3 Sensitivity3.2.4 Validation of HRMS-Based Methods; 3.2.5 Method Diagnosis Tools; 3.3 Analytical Methods for Veterinary Drug Residues; 3.3.1 Initial Applications (Non-antimicrobial Veterinary Drugs); 3.3.2 Methods Limited to a Single-Drug Group; 3.3.3 Methods Covering Multiple-Drug Groups; 3.3.4 Method Components; 3.3.5 Residue Testing of Anabolic Steroids and Growth Promoters; 3.4 Doping Control; 3.4.1 GC-HRMS; 3.4.2 Accurate Mass LC-MS and LC-MS/MS in Doping Control; 3.4.3 ""Dilutea and Shoot"" with Accurate Mass LC-MS; 3.5 Accurate Mass MS in Research and Metabolism Studies.