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Tumors in Domestic Animals.
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Somerset :
Wiley,
2016.
|
| Edición: | 5th ed. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Title Page ; Copyright Page; Contents; List ofÈContributors; Preface; Chapter 1 An Overview ofÈMolecular Cancer Pathogenesis, Prognosis, and Diagnosis; Fundamentals ofÈcancer biology; Genetic injury; Epigenetics; Tumor heterogeneity, tumor progression, andÈclonal evolution; The hallmarks ofÈmalignancy; Sustaining proliferative signaling: proto-oncogenes and oncogenes ; Evading growth suppressors; Resisting cell death; Enabling reproductive immortality; Inducing angiogenesis; Activating invasion andÈmetastasis; References.
- Veterinary cancer incidence andÈmolecular approaches toÈdiagnosis andÈprognosisGenetics andÈcancer; From concepts toÈclinics: molecular genetics usher inänëra oföpportunity; Cytogenetics inÈcancer; Molecular diagnostics andÈprognostics; Evolutionarily conserved genomic changes inÈcancers; Molecular assays inÈveterinary oncology; Conclusions; References; Chapter 2 Trimming Tumors forÈDiagnosis andÈPrognosis; Specimen sizing; Orientation ofẗrimmed specimens; Perpendicular margins; Parallel margins (en face); Margin evaluation; Skin tumors; Canine soft tissue sarcomas andÈmast cellẗumors.
- Digital amputationsLimb amputations; Ears; Eyelids; Intraocular tumors; Hemimandibulectomies/maxillectomies; Gastrointestinal tumors; Tumors ofÈparenchymal organs; Tumors ofÈlobar parenchymal organs; Lymph nodes; References; Chapter 3 Immunohistochemistry: Fundamentals andÄpplications inÖncology; Introduction; References; The immunohistochemical test; Fixation andÈprocessing; References; Antigen retrieval; Enzymatic retrieval; Heat-induced epitope retrieval (HIER) ; References; Antigens andäntibodies; Antigens; Antibodies; Affinity; Avidity; Polyclonal antibodies; Monoclonal antibodies.
- What makes anäntibody good forïmmunohistochemistry?References; Detection methods; Avidin-biotin methods; Polymeric labeling two-step method ; Catalyzed signal amplification; Immunohistochemistry onÈmouse tissues; References; Storage andḧandling ofÈreagents; References; Controls inïmmunohistochemistry; Positive tissue control; Negative tissue control; Reagent (antibody) controls; Methods for high-throughput evaluation of control tissues ; References; Standardization (optimization) andÈvalidationöfäÈnew IHC test; Primary antibody standardization andÈvalidation.
- Laboratory validation ofẗheÏHC testClinical validation ofẗheÏHC test; References; Immunohistochemical report andïnterpretation; Patterns ofÈspecific labeling; Patterns ofÈnonspecific labeling; What constitutes aÈpositive/significant result?; Distinguishing true-positive from false-positive immunoreactivity ; References; Troubleshooting theÏHC test; Background staining; References; Approach toẗheïmmunohistochemical characterization ofẗumors; Biomarkers inÈdiagnostic immunohistochemistry ofÈneoplasms; Prognostic markers andïmmunohistochemistry; References.