The application of toxicogenomics for (Drinking) water quality assessment /

Due to anthropogenic activities, freshwater systems worldwide are exposed to thousands of compounds. Monitoring of priority pollutants is important, however, monitoring of all individual compounds would be practically impossible. Moreover, the effects on human health remains mostly unknown since com...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores principales: Schriks, Merijn (Autor), Houtman, Corine (Autor), Van der Oost, Ron (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London, England : IWA Publishing, 2014.
Colección:KWR Watercycle Research Institute series.
Temas:
Water quality > Measurement.
Water > Pollution.
Eau > Qualité > Mesure.
SCIENCE > Applied Sciences.
Water > Pollution
Water quality > Measurement
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Introduction
  • Technical background
  • Biology
  • Toxicology
  • Genomics
  • Transcriptomics with DNA microarrays
  • Sensitivity
  • Analysis time
  • Responsiveness
  • Specificity
  • Cross species extrapolation
  • Toxicogenomics
  • Application of toxicogenomics
  • No Observable Transcriptional Effect Level (NOTEL) concept
  • Mode of action (MOA) approaches
  • Environmental monitoring
  • Risk assessment
  • Investigation of biological processes controlled by gene networks
  • Challenges for toxicogenomics
  • Model system complexity
  • Confounding factors
  • Mixtures
  • Limited sequence data
  • Bioinformatics
  • Costs
  • Research needs for regulatory implementation
  • Discussion on toxicogenomics for water quality monitoring
  • Mechanisms of toxicity and predictive toxicology
  • Environmental monitoring
  • NOTEL
  • Genomics as a tool for monitoring in relation to in vitro bioassays
  • Conclusions and outlook.

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