Prions and prion diseases : new developments /

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Verdier, Jean-Michel (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York : Nova Biomedical/Nova Science Publishers, Inc., [2012]
Colección:Protein biochemistry, synthesis, structure, and cellular functions series.
Protein science and engineering.
Temas:
Prions.
Prion diseases.
Prions (Virologie)
Maladies à prions.
SCIENCE > Life Sciences > Biology.
SCIENCE > Life Sciences > Microbiology.
Prion diseases
Prions
Acceso en línea:Texto completo
Tabla de Contenidos:
  • PRIONS AND PRION DISEASES
  • PRIONS AND PRION DISEASES
  • CONTENTS
  • PREFACE
  • NEUROPATHOLOGY OF HUMAN PRION DISEASES
  • ABSTRACT
  • INTRODUCTION
  • THE ROLE OF NEUROPATHOLOGY
  • PERFORMING THE AUTOPSY
  • NEUROPATHOLOGICAL EXAMINATION
  • A.) Macroscopy
  • B.) Work-Up for Histological Evaluation
  • C.) Microscopic Assessment
  • I.) Spongiform Change of the Neuropil
  • a) In Sporadic Forms
  • b.) In Genetic Forms
  • c.) In Acquired Forms
  • II) Neuronal Death
  • a.) In Sporadic Forms
  • b.) In Genetic Forms
  • c.) In Acquired Forms
  • SYNAPTIC PATHOLOGY III.) Astroglial Proliferation
  • IV.) Microglial Activation
  • V.) PrP Amyloid Plaques
  • a.) In Sporadic Forms
  • b.) In Genetic Forms
  • c.) In Acquired Forms
  • VI.) Cerebellar Pathology
  • a.) In Sporadic Forms
  • b.) In Genetic Forms
  • c.) In Acquired Forms
  • RELATIVE RESISTANCE OF HIPPOCAMPUS IN CJD
  • VII.) Detection of PrP
  • VIIa.) By Immunohistochemistry
  • a.) In Sporadic Forms
  • b.) In Genetic Forms
  • c.) In Acquired Forms
  • VIIb.) By histoblot and Paraffin-Embedded Tissue Blot
  • VIId.) By Western blota.) In Sporadic Forms
  • b.) In Genetic Forms
  • c.) In Acquired Forms
  • VIII.) Co-deposition of other Abnormal Protein Aggregates in CJD
  • a) In Sporadic Forms
  • b) In Genetic Forms
  • c) In Acquired Forms
  • IX.) Differential Diagnoses from Autopsy Series
  • X.) Neuronal Systems and Their Clinico-Pathological Correlates
  • CONCLUSION
  • ACKNOWLEDGMENTS
  • REFERENCES
  • THE NATURE OF THE INFECTIOUS AGENTS: PRP MODELS OF RESISTANT SPECIES TO PRION DISEASES (DOG, RABBIT AND HORSES)
  • Abstract
  • 1. Introduction
  • 2. MaterialsandMethods3. ResultsandDiscussion
  • 4. Conclusion
  • Acknowledgments
  • References
  • INDUCING TRANSMISSIBLE PRION DISEASES WITH RECOMBINANT FIBRILS: A NEW CONCEPT ON GENESIS AND EVOLUTION OF INFECTIOUS PRIONS
  • ABSTRACT
  • GENERATING TRANSMISSIBLE PRION DISEASES DE NOVO
  • THE MECHANISM OF TRIGGERING PRION DISEASE BY RPRP AMYLOID FIBRILS
  • EXPERIMENTAL EVIDENCE SUPPORT THE SECOND MODEL
  • THE HYPOTHESIS OF DEFORMED TEMPLATING
  • CONFORMATIONAL SWITCHING WITHIN INDIVIDUAL AMYLOID FIBRILS AND STRAIN ADAPTATION PHENOMENON
  • CROSS-TALK BETWEEN AMYLOIDOGENIC PROTEINS REFERENCES
  • SYNTHETIC PRIONS
  • ABSTRACT
  • 1. INTRODUCTION
  • 2. STRATEGIES FOR DE NOVO MAMMALIAN PRIONS GENERATION
  • 2.1. Cell-Free Assay Using Mammalian Prions
  • 2.2. De Novo Generation of Prions by Mouse Transgenesis
  • 2.3. In Vitro De Novo Prions by PMCA
  • 2.4. De Novo Prions by Amyloid Seeding Assay
  • 2.5. De Novo Prions by Annealing Technique
  • 2.6. Concluding Remarks and New Emerging Techniques for Prion Detection and Generation
  • 3. STRUCTURAL BIOLOGY OF NATURAL AND SYNTHETIC PRIONS

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