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Myelodysplastic syndromes : from pathogenesis to diagnosis and therapy /
Annotation
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York :
Nova Science Publishers,
2013.
|
| Colección: | Recent advances in hematology research series.
Stem cells--laboratory and clinical research series. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- MYELODYSPLASTIC SYNDROMES ; MYELODYSPLASTIC SYNDROMES ; Contents ; Preface ; An Introduction to Myelodysplastic Syndromes: Presentation, Diagnosis, Classification, and Prognostication ; Abstract ; Introduction ; Etiology ; Pathobiology ; Cytogenetic, Genetic, and Epigenetic Alterations ; Cytogenetic Abnormalities ; Genetic Abnormalities ; Epigenetic Abnormalities ; Role of Immune System ; Bone Marrow Microenvironment ; Deregulated Apoptosis (Programmed Cell Death) ; Clinical Presentation ; Diagnosis ; Bone Marrow Aspirate.
- Practical Technique to Assure Adequate Bone Marrow Particle Collection Bone Marrow Biopsy ; Touch Imprint and Clot Section ; Flow Cytometry ; Cytogenetics ; Atypical Forms of MDS ; MDS with Myelofibrosis ; Hypoplastic MDS ; Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN) ; Therapy Related MDS (t-MDS) ; 5q- Syndrome ; Classification ; Prognostication ; International Prognostic Scoring System (IPSS) ; WHO Prognostic Scoring System (WPSS) ; MD Anderson Cancer Center (MDACC) Model ; Revised IPSS (IPSS-R) ; Other Prognostic Factors ; Cytogenetics ; Bone Marrow Fibrosis ; Hypoplastic MDS.
- Therapy-Related MDS (t-MDS) 5q- Syndrome ; Neutropania ; Thrombocytopenia ; References ; Diagnostic Approach to Myelodysplastic Syndromes ; Abstract ; Introduction ; Diagnostic Approach ; Morphologic Features ; Immunophenotyping by Flow Cytometry ; Cytogenetic and Genetic Features ; Classification of Myelodisplastic Syndromes ; Refractory Cytopenia with Unilineage Dysplasia (RCUD) ; Refractory Anemia with Ring Sideroblasts (RARS) ; Refractory Cytopenia with Multilineage Dysplasia (RCMD) ; Refractory Anemia with Excess of Blasts (RAEB) ; Myelodysplastic Syndrome with Isolated del(5q).
- Myelodysplastic Syndrome, Unclassifiable (MDS-U) Myelodysplastic Syndromes with Unique Morphological Features ; MDS with Fibrosis (MDS-F) ; Hypoplastic MDS (h-MDS) ; Erythroid-Predominant MDS (MDS-E) ; Conclusion ; References ; Cytogenetic Features of Myelodysplastic Syndromes ; Abstract ; Introduction ; Cytogenetic Findings ; Cytogenetic Alterations and their Molecular Counterparts ; Y Chromosome Loss ; Rearrangements (3q) ; Deletion (5q) ; Rearrangements of 5q33 ; Partial or Total Loss of Chromosome 7: -7/del(7q) ; Trisomy 8 ; Deletion (17p) ; Deletion (20q) ; Complex Karyotype.
- Risk Stratification of Cytogenetic Findings in MDS Conclusion ; Acknowledgments ; References ; Molecular Genetic Abnormalitiesin Myelodysplastic Syndromes ; Abstract ; Introduction ; Mutations in Epigenetic Regulators in MDS ; Mutations of the DNMT3A Gene ; Mutations of the TET2 Gene ; Mutations of the IDH1 and IDH2 Genes ; Mutations of the EZH2 Gene ; Mutations of the UTX Gene ; Mutations of the ASXL1 Gene ; Mutations of the c-CBL Gene ; RUNX1 Mutations ; RAS Mutations in MDS ; TP53 Mutations ; Mutations in RNA Splicing Machinery; Mutations in Other Genes in MDS Patients.