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Patient Derived Tumor Xenograft Models : Promise, Potential and Practice.

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Uthamanthil, Rajesh
Otros Autores: Tinkey, Peggy, De Stanchina, Elisa
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Saint Louis : Elsevier Science, 2016.
Temas:
Acceso en línea:Texto completo

MARC

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245 1 0 |a Patient Derived Tumor Xenograft Models :  |b Promise, Potential and Practice. 
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505 0 |a Section I. Mouse Xenograft Models of Cancer 1. PDX models -- History and Advantages 2. History of Mouse Cancer Models 3. Challenges and limitations of mouse xenograft cancer models 4. Tumor heterogeneity 5. Immunocompromised mice -- the back bone of PDX models 6. Humanized mice and PDX models Section II. Components of a PDX program 1. Meeting the regulatory requirements 2. Tumor/clinical sample acquisition and storage 3. Methodology for developing and maintaining the PDX mouse model 4. Pathology of the PDX tumors 5. Profiling tumors in PDX models 6. Running a PDX core/support program 7. Veterinary Care 8. Occupational Health and Safety Section III. PDX models for tumors of various organ systems 1. PDX models of Brain Tumors 2. PDX models of Prostate Tumors 3. PDX models of Pancreatic Tumors 4. PDX models of Breast Tumors 5. PDX models of Ovarian/Gyenocologic Tumors 6. PDX models of Lung Tumors 7. PDX models of Colorectal Tumors 8. Liquid tumors 9. PDX Models of Melanoma 10. Ex vivo 3D modeling of PDX tumors Section IV. PDX models in cancer research and therapy around the world 1. Role of Academic institutions in development and support of PDX models 2. Role of Industry in development and support of PDX models Section V. Challenges & Future of PDX Models 1. Challenges in PDX models 2. Controlling variability in PDX models 3. Future of PDX models 
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700 1 |a Tinkey, Peggy. 
700 1 |a De Stanchina, Elisa. 
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776 0 8 |i Print version:  |a Uthamanthil, Rajesh.  |t Patient Derived Tumor Xenograft Models : Promise, Potential and Practice.  |d Saint Louis : Elsevier Science, ©2016  |z 9780128040102 
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