Mitochondrial replacement techniques : ethical, social, and policy considerations /

Mitochondrial replacement techniques (MRTs) are designed to prevent the transmission of mitochondrial DNA (mtDNA) diseases from mother to child. While MRTs, if effective, could satisfy a desire of women seeking to have a genetically related child without the risk of passing on mtDNA disease, the tec...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Claiborne, Anne B. (Editor ), English, Rebecca A. (Editor ), Kahn, Jeffrey P. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Washington, D.C. : National Academies Press, [2016]
Colección:Online access: NCBI NCBI Bookshelf.
Temas:
Reproductive technology > Moral and ethical aspects > United States.
Reproductive technology > Government policy > United States.
Mitochondrial DNA > Abnormalities > United States.
Mitochondrial pathology > United States.
Medical ethics > United States.
Mitochondrial DNA.
Mitochondrial Replacement Therapy > ethics
Mitochondrial Diseases > prevention & control
DNA, Mitochondrial
Reproduction > Innovations > Aspect moral > États-Unis.
Reproduction > Innovations > Politique gouvernementale > États-Unis.
Maladies mitochondriales > États-Unis.
Éthique médicale > États-Unis.
ADN mitochondrial.
HEALTH & FITNESS > Diseases > General.
MEDICAL > Clinical Medicine.
MEDICAL > Diseases.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Internal Medicine.
Mitochondrial DNA
Medical ethics
Mitochondrial DNA > Abnormalities
Mitochondrial pathology
Reproductive technology > Moral and ethical aspects
United States
Acceso en línea:Texto completo
Descripción
Sumario:Mitochondrial replacement techniques (MRTs) are designed to prevent the transmission of mitochondrial DNA (mtDNA) diseases from mother to child. While MRTs, if effective, could satisfy a desire of women seeking to have a genetically related child without the risk of passing on mtDNA disease, the technique raises significant ethical and social issues. It would create offspring who have genetic material from two women, something never sanctioned in humans, and would create mitochondrial changes that could be heritable (in female offspring), and therefore passed on in perpetuity. The manipulation would be performed on eggs or embryos, would affect every cell of the resulting individual, and once carried out this genetic manipulation is not reversible. Mitochondrial Replacement Techniques considers the implications of manipulating mitochondrial content both in children born to women as a result of participating in these studies and in descendants of any female offspring. This study examines the ethical and social issues related to MRTs, outlines principles that would provide a framework and foundation for oversight of MRTs, and develops recommendations to inform the Food and Drug Administration's consideration of investigational new drug applications.
Descripción Física:1 online resource (1 PDF file (xvi, 184 pages)) : illustrations
Bibliografía:Includes bibliographical references.
ISBN:9780309388702
0309388708
9780309388719
0309388716
0309388732
9780309388733

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