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Lysosomes : biology, diseases, and therapeutics /
Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development.- Explores basic principles and properties of lysosomes that allow them t...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken, New Jersey :
John Wiley & Sons, Inc.,
[2016]
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Lysosomes an introduction / Frederick R. Maxfield
- Lysosome biogenesis and autophagy / Fulvio Reggiori, Judith Klumperman
- Multivesicular bodies: roles in intracellular and intercellular signalling / Emily R. Eden, Thomas Burgoyne, Clare E. Futter
- Lysosomes and mitophagy / Dominik Haddad, Patrik Verstreken
- Lysosome exocytosis and membrane repair / Rajesh K. Singh, Abigail S. Haka
- Role of lysosomes in lipid metabolism / Frederick R. Maxfield
- TFEB, master regulator of cellular clearance / Graciana Diez-Roux and Andrea Ballabio
- Lysosomal membrane permeabilization in cell death / Urska Repnik, Boris Turk
- The lysosome in aging-related neurodegenerative diseases / Ralph A. Nixon
- Lysosome and cancer / Marja Jaattela and Tuula Kallunki
- The genetics of sphingolipid hydrolases & sphingolipid storage diseases / Edward H. Schuchman and Calogera M. Simonaro
- Lysosome-related organelles : modifications of the lysosome paradigm / Adriana R. Mantegazza and Michael S. Marks
- Autophagy inhibition as a strategy for cancer therapy / Xiaohong Ma, Shengfu Piao, Quentin Mcafee, and Ravi K. Amaravadi
- Autophagy enhancers, are we there yet? / Shuyan Lu & Ralph A Nixon
- Pharmacological chaperones as potential therapeutics for lysosomal storage disorders: preclinical research to clinical studies / Robert E. Boyd, Elfrida R. Benjamin, Su Xu, Richie Khanna, and Kenneth J. Valenzano
- Endosomal escape pathways for delivery of biologics / Philip L. Leopold
- Lysosomes and antibody drug conjugates / Michelle Mack, Jennifer Kahler, Boris Shor, Michael Ritchie, Maureen Dougher, Matthew Sung, and Puja Sapra
- The mechanisms and therapeutic consequences of amine-containing drug sequestration in lysosomes / Nadia Hamid and Jeffrey P. Krise
- Lysosome dysfunction : an emerging mechanism of xenobiotic-induced toxicity / Shuyan Lu, Bart Jessen, Yvonne Will & Greg Stevens
- Lysosomes and phospholipidosis in drug development and regulation / James M. Willard and Albert De Felice.