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Lysosomes : biology, diseases, and therapeutics /
Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development.- Explores basic principles and properties of lysosomes that allow them t...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken, New Jersey :
John Wiley & Sons, Inc.,
[2016]
|
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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|---|---|---|---|
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| 049 | |a UAMI | ||
| 130 | 0 | |a Lysosomes (Maxfield) | |
| 245 | 1 | 0 | |a Lysosomes : |b biology, diseases, and therapeutics / |c edited by Frederick R. Maxfield, James M. Willard, Shuyan Lu. |
| 264 | 1 | |a Hoboken, New Jersey : |b John Wiley & Sons, Inc., |c [2016] | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Lysosomes an introduction / Frederick R. Maxfield -- Lysosome biogenesis and autophagy / Fulvio Reggiori, Judith Klumperman -- Multivesicular bodies: roles in intracellular and intercellular signalling / Emily R. Eden, Thomas Burgoyne, Clare E. Futter -- Lysosomes and mitophagy / Dominik Haddad, Patrik Verstreken -- Lysosome exocytosis and membrane repair / Rajesh K. Singh, Abigail S. Haka -- Role of lysosomes in lipid metabolism / Frederick R. Maxfield -- TFEB, master regulator of cellular clearance / Graciana Diez-Roux and Andrea Ballabio -- Lysosomal membrane permeabilization in cell death / Urska Repnik, Boris Turk -- The lysosome in aging-related neurodegenerative diseases / Ralph A. Nixon -- Lysosome and cancer / Marja Jaattela and Tuula Kallunki -- The genetics of sphingolipid hydrolases & sphingolipid storage diseases / Edward H. Schuchman and Calogera M. Simonaro -- Lysosome-related organelles : modifications of the lysosome paradigm / Adriana R. Mantegazza and Michael S. Marks -- Autophagy inhibition as a strategy for cancer therapy / Xiaohong Ma, Shengfu Piao, Quentin Mcafee, and Ravi K. Amaravadi -- Autophagy enhancers, are we there yet? / Shuyan Lu & Ralph A Nixon -- Pharmacological chaperones as potential therapeutics for lysosomal storage disorders: preclinical research to clinical studies / Robert E. Boyd, Elfrida R. Benjamin, Su Xu, Richie Khanna, and Kenneth J. Valenzano -- Endosomal escape pathways for delivery of biologics / Philip L. Leopold -- Lysosomes and antibody drug conjugates / Michelle Mack, Jennifer Kahler, Boris Shor, Michael Ritchie, Maureen Dougher, Matthew Sung, and Puja Sapra -- The mechanisms and therapeutic consequences of amine-containing drug sequestration in lysosomes / Nadia Hamid and Jeffrey P. Krise -- Lysosome dysfunction : an emerging mechanism of xenobiotic-induced toxicity / Shuyan Lu, Bart Jessen, Yvonne Will & Greg Stevens -- Lysosomes and phospholipidosis in drug development and regulation / James M. Willard and Albert De Felice. | |
| 588 | 0 | |a Print version record and CIP data provided by publisher. | |
| 520 | |a Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development.- Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates - Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair- Introduces new pathways in therapeutic development and new mechanisms in drug development. | ||
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Lysosomes. | |
| 650 | 2 | |a Lysosomes | |
| 650 | 6 | |a Lysosomes. | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Anatomy & Physiology. |2 bisacsh | |
| 650 | 7 | |a Lysosomes |2 fast | |
| 700 | 1 | |a Maxfield, Frederick R., |e editor. | |
| 700 | 1 | |a Willard, James M., |d 1955- |e editor. | |
| 700 | 1 | |a Lu, Shuyan, |d 1971- |e editor. | |
| 758 | |i has work: |a Lysosomes (Text) |1 https://id.oclc.org/worldcat/entity/E39PCGmjMwbfKhJXMTmPwt7gGb |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
| 776 | 0 | 8 | |i Print version: |d Hoboken, New Jersey : John Wiley & Sons, Inc., [2016] |z 9781118645154 |w (DLC) 2016006834 |
| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=4537246 |z Texto completo |
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| 938 | |a ProQuest MyiLibrary Digital eBook Collection |b IDEB |n cis31145096 | ||
| 938 | |a Recorded Books, LLC |b RECE |n rbeEB00681232 | ||
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| 994 | |a 92 |b IZTAP | ||