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Calculating the Secrets of Life : Contributions of the Mathematical Sciences to Molecular Biology.
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Washington :
National Academies Press,
1994.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Calculating the Secrets of Life; Copyright; Preface; Contents; Calculating the Secrets of Life; Chapter 1 The Secrets of Life: A Mathematician's Introduction to Molecular Biology ; BIOCHEMISTRY; CLASSICAL GENETICS; MOLECULAR BIOLOGY; THE RECOMBINANT DNA REVOLUTION; MOLECULAR GENETICS IN THE 1990S; THE HUMAN GENOME PROJECT; COMING ATTRACTIONS; REFERENCES; Chapter 2 Mapping Heredity: Using Probabilistic Models and Algorithms to Map Genes and Genomes ; GENETIC MAPPING; The Concept of Genetic Maps; Challenges of Genetic Mapping: Human Families and Complex Traits; MAXIMUM LIKELIHOOD ESTIMATION.
- Efficient AlgorithmsStatistical Significance; Excursion: Susceptibility to Colon Cancer in Mice and the Large Deviation Theory of Diffusion Processes; PHYSICAL MAPPING; Assembling Physical Maps by ""Fingerprinting"" Random Clones; Excursion: Designing a Strategy to Map the Human Genome; CONCLUSION; REFERENCES; Chapter 3 Seeing Conserved Signals: Using Algorithms to Detect Similarities between Biosequences ; FINDING GLOBAL SIMILARITIES; Visualizing Alignments: Edit Graphs; The Basic Dynamic Programming Algorithm; FINDING LOCAL SIMILARITIES; VARIATIONS ON SEQUENCE COMPARISON.
- Variations in Gap Cost PenaltiesThe Duality Between Similarity and Difference Measures; Aligning More Than Two Sequences at a Time; K-Best Alignments; Approximate Pattern Matching; Parallel Computing; COMPARING ONE SEQUENCE AGAINST A DATABASE; Heuristic Algorithms; Sublinear Similarity Searches; OPEN PROBLEMS; REFERENCES; Chapter 4 Hearing Distant Echoes: Using Extremal Statistics to Probe Evolutionary Origins ; GLOBAL SEQUENCE COMPARISONS; Sequence Alignment; Alignment Given; Alignment Unknown; LOCAL SEQUENCE COMPARISONS; Alignment Given; Alignment Unknown; APPLICATION TO RNA EVOLUTION.
- TWO BEHAVIORS SUFFICERNA EVOLUTION REVISITED; REFERENCES; Chapter 5 Calibrating the Clock: Using Stochastic Processes to Measure the Rate of Evolution ; OVERVIEW; THE COALESCENT AND MUTATION; The Ewens Sampling Formula; Forwards and Backwards in the Tree; Top-down; Bottom-up; The Infinitely-Many-Sites Model; K-Allele Models; The Finitely-Many-Sites Models; MATHEMATICAL VIGNETTE: APPROXIMATING COMBINATORIAL STRUCTURES; Approximations for the Ewens Sampling Formula; Combinatorial Assemblies; Other Combinatorial Structures; The Large Components; WHERE TO NEXT?; Likelihood Methods; Discussion.