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|a 9780309556163
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|a 0309556163
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|a 0309048869
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|a 9780309048866
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|a (OCoLC)940510397
|z (OCoLC)994347485
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|a QH438.4.M3
|b C35 1995eb
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|a 574.8/8/0151
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|a UAMI
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|a Lander, Eric S.
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|a Calculating the Secrets of Life :
|b Contributions of the Mathematical Sciences to Molecular Biology.
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| 260 |
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|a Washington :
|b National Academies Press,
|c 1994.
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| 300 |
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|a 1 online resource (299 pages)
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a Print version record.
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|a Calculating the Secrets of Life; Copyright; Preface; Contents; Calculating the Secrets of Life; Chapter 1 The Secrets of Life: A Mathematician's Introduction to Molecular Biology ; BIOCHEMISTRY; CLASSICAL GENETICS; MOLECULAR BIOLOGY; THE RECOMBINANT DNA REVOLUTION; MOLECULAR GENETICS IN THE 1990S; THE HUMAN GENOME PROJECT; COMING ATTRACTIONS; REFERENCES; Chapter 2 Mapping Heredity: Using Probabilistic Models and Algorithms to Map Genes and Genomes ; GENETIC MAPPING; The Concept of Genetic Maps; Challenges of Genetic Mapping: Human Families and Complex Traits; MAXIMUM LIKELIHOOD ESTIMATION.
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|a Efficient AlgorithmsStatistical Significance; Excursion: Susceptibility to Colon Cancer in Mice and the Large Deviation Theory of Diffusion Processes; PHYSICAL MAPPING; Assembling Physical Maps by ""Fingerprinting"" Random Clones; Excursion: Designing a Strategy to Map the Human Genome; CONCLUSION; REFERENCES; Chapter 3 Seeing Conserved Signals: Using Algorithms to Detect Similarities between Biosequences ; FINDING GLOBAL SIMILARITIES; Visualizing Alignments: Edit Graphs; The Basic Dynamic Programming Algorithm; FINDING LOCAL SIMILARITIES; VARIATIONS ON SEQUENCE COMPARISON.
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|a Variations in Gap Cost PenaltiesThe Duality Between Similarity and Difference Measures; Aligning More Than Two Sequences at a Time; K-Best Alignments; Approximate Pattern Matching; Parallel Computing; COMPARING ONE SEQUENCE AGAINST A DATABASE; Heuristic Algorithms; Sublinear Similarity Searches; OPEN PROBLEMS; REFERENCES; Chapter 4 Hearing Distant Echoes: Using Extremal Statistics to Probe Evolutionary Origins ; GLOBAL SEQUENCE COMPARISONS; Sequence Alignment; Alignment Given; Alignment Unknown; LOCAL SEQUENCE COMPARISONS; Alignment Given; Alignment Unknown; APPLICATION TO RNA EVOLUTION.
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|a TWO BEHAVIORS SUFFICERNA EVOLUTION REVISITED; REFERENCES; Chapter 5 Calibrating the Clock: Using Stochastic Processes to Measure the Rate of Evolution ; OVERVIEW; THE COALESCENT AND MUTATION; The Ewens Sampling Formula; Forwards and Backwards in the Tree; Top-down; Bottom-up; The Infinitely-Many-Sites Model; K-Allele Models; The Finitely-Many-Sites Models; MATHEMATICAL VIGNETTE: APPROXIMATING COMBINATORIAL STRUCTURES; Approximations for the Ewens Sampling Formula; Combinatorial Assemblies; Other Combinatorial Structures; The Large Components; WHERE TO NEXT?; Likelihood Methods; Discussion.
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|a REFERENCESGeneral-Purpose References; Detailed References; Chapter 6 Winding the Double Helix: Using Geometry, Topology, and Mechanics of DNA ; DNA GEOMETRY AND TOPOLOGY: LINKING, TWISTING, AND WRITHING; APPLICATIONS TO DNA TOPOISOMERASE REACTIONS; DNA ON PROTEIN COMPLEXES; THE SURFACE LINKING NUMBER; THE WINDING NUMBER AND HELICAL REPEAT; RELATIONSHIP BETWEEN LINKING, SURFACE LINKING, AND WINDING; APPLICATION TO THE STUDY OF THE MINICHROMOSOME; REFERENCES; Chapter 7 Unwinding the Double Helix: Using Differential Mechanics to Probe Conformational Changes ...
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|a Dna superhelicity-mathematics and biology.
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| 546 |
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|a English.
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| 590 |
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|a ProQuest Ebook Central
|b Ebook Central Academic Complete
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| 650 |
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|a Genetics
|x Mathematical models.
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| 650 |
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|a Genetics
|x Statistical methods.
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| 650 |
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|a Molecular biology
|x Mathematical models.
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| 650 |
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|a Molecular biology
|x Statistical methods.
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| 650 |
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|a Mathematics.
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| 650 |
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|a Biology.
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| 650 |
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|a Biochemistry.
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| 650 |
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|a Life sciences.
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| 650 |
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|a Chemistry.
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| 650 |
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|a Physical sciences.
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| 650 |
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|a Public health.
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| 650 |
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|a Statistics.
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| 650 |
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|a Mathematical models.
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| 650 |
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|a Medical care.
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| 650 |
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2 |
|a Mathematics
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| 650 |
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2 |
|a Biology
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| 650 |
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2 |
|a Genetics
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| 650 |
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2 |
|a Molecular Biology
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| 650 |
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2 |
|a Health Care Evaluation Mechanisms
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| 650 |
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2 |
|a Epidemiologic Methods
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| 650 |
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2 |
|a Biochemistry
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| 650 |
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2 |
|a Investigative Techniques
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| 650 |
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2 |
|a Biological Science Disciplines
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| 650 |
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2 |
|a Analytical, Diagnostic and Therapeutic Techniques and Equipment
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| 650 |
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|a Chemistry
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| 650 |
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2 |
|a Natural Science Disciplines
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| 650 |
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|a Public Health
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| 650 |
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|a Quality of Health Care
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| 650 |
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|a Statistics as Topic
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| 650 |
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|a Models, Theoretical
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| 650 |
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|a Health Care Quality, Access, and Evaluation
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| 650 |
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|a Disciplines and Occupations
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| 650 |
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|a Environment and Public Health
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| 650 |
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|a Delivery of Health Care
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| 650 |
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2 |
|a Patient Care
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| 650 |
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6 |
|a Génétique
|x Méthodes statistiques.
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| 650 |
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|a Biologie moléculaire
|x Modèles mathématiques.
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| 650 |
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|a Biologie moléculaire
|x Méthodes statistiques.
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| 650 |
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|a Mathématiques.
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| 650 |
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|a Biologie.
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| 650 |
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|a Biochimie.
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| 650 |
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|a Sciences de la vie.
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| 650 |
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|a Chimie.
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| 650 |
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|a Sciences physiques.
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| 650 |
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|a Santé publique.
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| 650 |
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|a Statistiques.
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| 650 |
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|a Modèles mathématiques.
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| 650 |
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|a Prestation de soins.
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| 650 |
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|a Statistique.
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| 650 |
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|a Soins médicaux.
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| 650 |
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7 |
|a biology.
|2 aat
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| 650 |
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7 |
|a biochemistry.
|2 aat
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| 650 |
|
7 |
|a biological sciences.
|2 aat
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| 650 |
|
7 |
|a chemistry.
|2 aat
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| 650 |
|
7 |
|a physical sciences.
|2 aat
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| 650 |
|
7 |
|a public health.
|2 aat
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| 650 |
|
7 |
|a mathematical models.
|2 aat
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| 650 |
|
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|a statistics.
|2 aat
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| 650 |
|
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|a Statistics
|2 fast
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| 650 |
|
7 |
|a Public health
|2 fast
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| 650 |
|
7 |
|a Physical sciences
|2 fast
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| 650 |
|
7 |
|a Medical care
|2 fast
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| 650 |
|
7 |
|a Mathematics
|2 fast
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| 650 |
|
7 |
|a Mathematical models
|2 fast
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| 650 |
|
7 |
|a Life sciences
|2 fast
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| 650 |
|
7 |
|a Chemistry
|2 fast
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| 650 |
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7 |
|a Biology
|2 fast
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| 650 |
|
7 |
|a Biochemistry
|2 fast
|
| 650 |
|
7 |
|a Genetics
|x Mathematical models
|2 fast
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| 650 |
|
7 |
|a Genetics
|x Statistical methods
|2 fast
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| 650 |
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7 |
|a Molecular biology
|x Mathematical models
|2 fast
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| 650 |
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7 |
|a Molecular biology
|x Statistical methods
|2 fast
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| 700 |
1 |
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|a Waterman, Michael S.
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| 700 |
1 |
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|a Staff, National Research Council.
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| 758 |
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|i has work:
|a Calculating the secrets of life (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCH3pc4HXHm6tgXmRGrvpdP
|4 https://id.oclc.org/worldcat/ontology/hasWork
|
| 776 |
0 |
8 |
|i Print version:
|a Lander, Eric S.
|t Calculating the Secrets of Life : Contributions of the Mathematical Sciences to Molecular Biology.
|d Washington : National Academies Press, ©1994
|z 9780309048866
|
| 856 |
4 |
0 |
|u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=3376940
|z Texto completo
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| 938 |
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|a ProQuest Ebook Central
|b EBLB
|n EBL3376940
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| 994 |
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|a 92
|b IZTAP
|
