Bioreactors : design, operation and novel applications /

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In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Mandenius, Carl-Fredrik, 1954- (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Weinheim : Wiley-VCH Verlag GmbH & Co., [2016]
Temas:
Bioreactors > Design and construction.
SCIENCE > Chemistry > Industrial & Technical.
TECHNOLOGY & ENGINEERING > Chemical & Biochemical.
Bioreactors > Design and construction
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Title Page
  • Copyright
  • Table of Contents
  • Preface
  • List of Contributors
  • Chapter 1: Challenges for Bioreactor Design and Operation
  • 1.1 Introduction
  • 1.2 Biotechnology Milestones with Implications on Bioreactor Design
  • 1.3 General Features of Bioreactor Design
  • 1.4 Recent Trends in Designing and Operating Bioreactors
  • 1.5 The Systems Biology Approach
  • 1.6 Using Conceptual Design Methodology
  • 1.7 An Outlook on Challenges for Bioreactor Design and Operation
  • References
  • Chapter 2: Design and Operation of Microbioreactor Systems for Screening and Process Development.
  • 2.1 Introduction
  • 2.2 Key Engineering Parameters and Properties in Microbioreactor Design and Operation
  • 2.3 Design of Novel Stirred and Bubble Aerated Microbioreactors
  • 2.4 Robotics for Microbioreactors
  • 2.5 Fed-Batch and Continuous Operation of Microbioreactors
  • 2.6 Monitoring and Control of Microbioreactors
  • 2.7 Conclusion
  • References
  • Chapter 3: Bioreactors on a Chip
  • 3.1 Introduction
  • 3.2 Advantages of Microsystems
  • 3.3 Scaling Down the Bioreactor to the Microfluidic Format
  • 3.4 Microfabrication Methods for Bioreactors-On-A-Chip
  • 3.5 Fabrication Materials.
  • 3.6 Integrated Sensors for Key Bioreactor Parameters
  • 3.7 Model Organisms Applied to BRoCs
  • 3.8 Applications of Microfluidic Bioreactor Chip
  • 3.9 Scale Up
  • 3.10 Conclusion
  • References
  • Chapter 4: Scalable Manufacture for Cell Therapy Needs
  • 4.1 Introduction
  • 4.2 Requirements for Cell Therapy
  • 4.3 Stem Cell Types and Products
  • 4.4 Paradigms in Cell Therapy Manufacture
  • 4.5 Cell Therapy Manufacturing Platforms
  • 4.6 Microcarriers and Stirred-Tank Bioreactors
  • 4.7 Future Trends for Microcarrier Culture
  • 4.8 Preservation of Cell Therapy Products
  • 4.9 Conclusions.
  • 6.2 Culture Technologies for Pluripotent Stem Cell Expansion
  • 6.3 3D Suspension Culture
  • 6.4 Autologous Versus Allogeneic Cell Therapies: Practical and Economic Considerations for hPSC Processing
  • 6.5 Upscaling hPSC Cardiomyogenic Differentiation in Bioreactors
  • 6.6 Conclusion
  • References
  • Chapter 7: Culturing Entrapped Stem Cells in Continuous Bioreactors
  • 7.1 Introduction
  • 7.2 Materials Used in Stem Cell Entrapment
  • 7.3 Synthetic Materials
  • 7.4 Natural Materials
  • 7.5 Manufacturing and Regulatory Constraints
  • 7.6 Mass Transfer in the Entrapment Material.

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