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Gender, sex hormones and respiratory disease : a comprehensive guide /
This book discusses normal sex-related differences in lung structure and function and the role these differences play in lung disease. New research on the effects of sex hormone signaling on specific cell types of the lung has begun to reveal how these hormones may drive or prevent lung disease. Exp...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cham :
Humana Press,
[2015]
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| Colección: | Respiratory medicine (New York, N.Y.)
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Preface; Contents; Contributors; Chapter 1: Sex Differences in Normal Pulmonary Structure and Function at Rest and During Exercise; Introduction; Normal Hormonal Fluctuations; Morphology; Pulmonary Function During Exercise; Pulmonary Gas Exchange; Gas Exchange at Rest and During Exercise; Exercise-Induced Arterial Hypoxemia; Ventilation-Perfusion Mismatch; Shunts; Diffusion Limitation; Inadequate Hyperventilation; Ventilation; Expiratory Flow Limitation; Respiratory Work/Muscles; Work of Breathing; Metabolic Cost of Breathing; Exercise-Induced Respiratory Muscle Fatigue
- Across the Life span (Children to Aging)Children; Aging; Summary; References; Chapter 2: Sex Hormone Signaling in the Lung in Health and Disease: Airways, Parenchyma, and Pulmonary Vasculature; Introduction; Overview of Sex Hormone Synthesis, Signaling, and Regulation; Sex Hormone Synthesis and Metabolism; The Role of Biologically Active Estrogen Metabolites (Fig. 2.2); Mechanisms of Estrogen-Mediated Signaling; Regulation of Estrogen Signaling; Progesterone and Androgen-Mediated Signaling; Regulation of Progesterone and Androgen Signaling; Sex Hormones and Lung Development
- Sex Hormones and the Prenatal and Early Postnatal Lung Sex Differences in the Pubescent Lung; Sex Differences in the Aging Lung; Effects of Sex Hormones on the Healthy Lung; Bronchial Epithelium; Alveolar Epithelium; Airway Smooth Muscle; Parenchyma; Pulmonary Vasculature; Immune Cells; Sex Hormone Effects on Respiratory Mechanics and Respiratory Control; Clinical Implications; Conclusions and Future Directions; References; Chapter 3: Women and COPD; Introduction; Risk Factors; Disease Prevalence; Mortality; Bias in Diagnosis; Tobacco Susceptibility; Disease Presentation
- Health Care Utilization and Management Differences in Disease Biology and Phenotype; Comorbidities in COPD; Therapeutic Implications; Tobacco Cessation; Pharmacotherapeutics; Pulmonary Rehabilitation; Oxygen Therapy; Conclusions; References; Chapter 4: Sex, Gender, and Asthma; Classifications Systems for Patients with Asthma; Host Immune Responses in Asthma; Changes in Sex Hormones during Puberty, Pregnancy, and Menopause Adversely Affect a Subset of Women with Asthma; Pre- and Perimenstrual Asthma Symptoms; Pregnancy and Asthma; Menopause and Asthma; Summary
- Sex Hormones in Mouse Models of AsthmaBaseline AHR and Airway Physiology in Female and Male Mice; Establishment of Allergic Airway Inflammation in Mice; Other Triggers of Asthma and the Role of Sex Hormones on Immune Cells; Summary of Sex Hormones and Asthma; References; Chapter 5: Sex Hormones, Sex, Gender, and Pulmonary Hypertension; Introduction; Sex and the Epidemiology of PAH: Prevalent Cases Skew toward Females; The Association Between Sex Hormones and Human PAH; The Pulmonary Vasculature: Effects of Sex Hormones; Beyond Parent Compound Sex Hormones: Metabolites; Conclusion