Structure to function of G protein-gated inwardly rectifying (GIRK) channels /

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Slesinger, Paul A. (Editor ), Wickman, Kevin D. (Kevin David) (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam : Academic Press, 2015.
Colección:International review of neurobiology.
Temas:
Potassium channels.
G proteins > Pathophysiology.
Substance abuse > Pathophysiology.
Receptors, G-Protein-Coupled
Potassium Channels
Canaux à potassium.
Protéines G > Physiopathologie.
Polytoxicomanie > Physiopathologie.
SCIENCE > Life Sciences > Biochemistry.
Substance abuse > Pathophysiology
Potassium channels
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Preface
  • Chapter One: Unifying Mechanism of Controlling Kir3 Channel Activity by G Proteins and Phosphoinositides
  • Abstract
  • 1 Introduction
  • 2 Regulation of KACh by G Proteins
  • 3 Molecular Constituents of Kir3 Channels and Physiological Roles
  • 4 Dependence of KACh Channel Activity on PIPs
  • 5 Physiological Significance of Distinct Membrane-Delimited Signaling Mechanisms
  • 6 Molecular Mechanism of PIP2 Control of Kir Channel Gating
  • 7 Posttranslational Modification Can Control Activity Through Changes in Channelâ€"PIP2 Interactions8 The Kir3 Channel Site of Gβγ Action
  • Chapter Two: The Roles of Gβγ and Gα in Gating and Regulation of GIRK Channels
  • Abstract
  • 1 Introduction
  • 2 Interaction of Gα and Gβγ With GIRK
  • 3 Roles of Gβγ and Gα in GIRK's Evoked and Basal Activity
  • 4 Basal Activity of GIRKs
  • 5 Multimolecular Signaling Complex and the Mechanism of GIRK Activation
  • Acknowledgments
  • Chapter Three: RGS Redundancy and Implications in GPCRâ€"GIRK Signaling
  • 2 Selectivity and Permeation3 Rectification
  • 4 Gating
  • 5 Conclusions
  • Acknowledgments
  • Chapter Five: Localization and Targeting of GIRK Channels in Mammalian Central Neurons
  • Abstract
  • 1 Introduction
  • 2 Molecular Organization and Heterogeneity of GIRK Channels
  • 3 Neuroanatomical Approaches to the Study of GIRK Channel Distribution
  • 4 Regional Distribution of GIRK Channel Subunits in the CNS
  • 5 Cellular Distribution of GIRK Channel Subunits
  • 6 Subcellular Distribution of GIRK Channel Subunits
  • 7 Developmental Aspects of GIRK Channel Distribution8 Conclusions and Future Perspectives
  • Acknowledgments
  • Chapter Six: GIRK Channel Plasticity and Implications for Drug Addiction
  • Abstract
  • 1 Introduction
  • 2 GIRK Channels in the Mesocorticolimbic System
  • 3 Drug-Dependent Plasticity of GIRK Channel-Dependent Signaling
  • 4 Mechanisms Underlying the Plasticity of GIRK Channel-Dependent Signaling
  • 5 Concluding Thoughts and Future Directions
  • Acknowledgments
  • Chapter Seven: GIRK Channels: A Potential Link Between Learning and Addiction
  • Abstract

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