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150729s2015 ne ob 001 0 eng d |
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|a 927491793
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|q (hbk.)
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|a (OCoLC)932055312
|z (OCoLC)927491793
|z (OCoLC)1002904591
|z (OCoLC)1005823803
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|z (OCoLC)1088963153
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|a SCI
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|2 bisacsh
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|a 572.3
|2 23
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|a UAMI
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245 |
0 |
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|a Structure to function of G protein-gated inwardly rectifying (GIRK) channels /
|c volume editors, Paul A. Slesinger, Kevin Wickman.
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264 |
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1 |
|a Amsterdam :
|b Academic Press,
|c 2015.
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300 |
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|a 1 online resource
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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490 |
1 |
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|a International Review of Neurobiology ;
|v v. Volume 123
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588 |
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|a CIP data; item not viewed.
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|a Title page -- Table of Contents -- Copyright -- Contributors -- Preface -- Chapter One: Unifying Mechanism of Controlling Kir3 Channel Activity by G Proteins and Phosphoinositides -- Abstract -- 1 Introduction -- 2 Regulation of KACh by G Proteins -- 3 Molecular Constituents of Kir3 Channels and Physiological Roles -- 4 Dependence of KACh Channel Activity on PIPs -- 5 Physiological Significance of Distinct Membrane-Delimited Signaling Mechanisms -- 6 Molecular Mechanism of PIP2 Control of Kir Channel Gating
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|a 7 Posttranslational Modification Can Control Activity Through Changes in Channelâ€"PIP2 Interactions8 The Kir3 Channel Site of Gβγ Action -- Chapter Two: The Roles of Gβγ and Gα in Gating and Regulation of GIRK Channels -- Abstract -- 1 Introduction -- 2 Interaction of Gα and Gβγ With GIRK -- 3 Roles of Gβγ and Gα in GIRK's Evoked and Basal Activity -- 4 Basal Activity of GIRKs -- 5 Multimolecular Signaling Complex and the Mechanism of GIRK Activation -- Acknowledgments -- Chapter Three: RGS Redundancy and Implications in GPCRâ€"GIRK Signaling
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|a 2 Selectivity and Permeation3 Rectification -- 4 Gating -- 5 Conclusions -- Acknowledgments -- Chapter Five: Localization and Targeting of GIRK Channels in Mammalian Central Neurons -- Abstract -- 1 Introduction -- 2 Molecular Organization and Heterogeneity of GIRK Channels -- 3 Neuroanatomical Approaches to the Study of GIRK Channel Distribution -- 4 Regional Distribution of GIRK Channel Subunits in the CNS -- 5 Cellular Distribution of GIRK Channel Subunits -- 6 Subcellular Distribution of GIRK Channel Subunits
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|a 7 Developmental Aspects of GIRK Channel Distribution8 Conclusions and Future Perspectives -- Acknowledgments -- Chapter Six: GIRK Channel Plasticity and Implications for Drug Addiction -- Abstract -- 1 Introduction -- 2 GIRK Channels in the Mesocorticolimbic System -- 3 Drug-Dependent Plasticity of GIRK Channel-Dependent Signaling -- 4 Mechanisms Underlying the Plasticity of GIRK Channel-Dependent Signaling -- 5 Concluding Thoughts and Future Directions -- Acknowledgments -- Chapter Seven: GIRK Channels: A Potential Link Between Learning and Addiction -- Abstract
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|a Includes bibliographical references and index.
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520 |
8 |
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|a Annotation
|b A comprehensive overview of state-of-the-art research into GIRK potassium channels. It reviews current knowledge and understanding, providing a starting point for researchers and practitioners entering the field.
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590 |
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|a ProQuest Ebook Central
|b Ebook Central Academic Complete
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650 |
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0 |
|a Potassium channels.
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650 |
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|a G proteins
|x Pathophysiology.
|
650 |
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0 |
|a Substance abuse
|x Pathophysiology.
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650 |
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2 |
|a Receptors, G-Protein-Coupled
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650 |
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2 |
|a Potassium Channels
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650 |
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6 |
|a Canaux à potassium.
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650 |
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6 |
|a Protéines G
|x Physiopathologie.
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650 |
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|a Polytoxicomanie
|x Physiopathologie.
|
650 |
|
7 |
|a SCIENCE
|x Life Sciences
|x Biochemistry.
|2 bisacsh
|
650 |
|
7 |
|a Substance abuse
|x Pathophysiology
|2 fast
|
650 |
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7 |
|a Potassium channels
|2 fast
|
700 |
1 |
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|a Slesinger, Paul A.,
|e editor.
|
700 |
1 |
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|a Wickman, Kevin D.
|q (Kevin David),
|e editor.
|1 https://id.oclc.org/worldcat/entity/E39PCjDpXqHjkpb6Ckx7yhgh73
|
758 |
|
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|i has work:
|a Structure to function of G protein-gated inwardly rectifying (GIRK) channels (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCGHYttBtRj3vpJTdqmxcHd
|4 https://id.oclc.org/worldcat/ontology/hasWork
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|i Print version
|z 9780128024584
|
830 |
|
0 |
|a International review of neurobiology.
|
856 |
4 |
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|u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=4012251
|z Texto completo
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