Liver Diseases : Biochemical Mechanisms and New Therapeutic Insights.

This book presents state-of-art information summarizing the current understanding of a range of liver diseases, and reviews some key diagnostic and therapeutic advances. The book is a collection of selected clinical and scientific topics divided into two volumes, each divided into two sections. The...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Ali, Shakir
Otros Autores: Friedman, Scott L., Mann, Derek A.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Enfield : Science Publishers, 2006.
Temas:
Liver > Diseases.
Liver > Pathophysiology.
Foie > Physiopathologie.
Liver > Diseases
Liver > Pathophysiology
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Preface
  • Contents
  • About the Editors
  • About the Authors
  • Sectionâ€?I: Liver Diseases: Mediators and Regulation
  • 1. Collagen Gene Regulation in the Hepatic Stellate Cell
  • 1. Introduction
  • 2. Molecular mechanisms controlling collagen synthesis
  • 3. Mediators influencing collagen expression in HSCs
  • 4. Posttranscriptional regulation of type I collagen expression
  • References
  • 2. CYP2E1â€?Biochemical and Toxicological Aspects and Role in Alcohol-induced Liver Injury
  • 1. Introduction
  • 2. CYP2E1
  • 3. CYP2E1 and alcohol-induced liver injury
  • 4. Biochemical and toxicological properties of CYP2E1 in HEPG2 cells5. Future perspectives
  • References
  • 3. Alcohol and Methyl Transfer: Implications for Alcohol-related Hepatocarcinogenesis
  • 1. Introduction
  • 2. Alcohol-related hepatocarcinogenesis: A multi-step process
  • 3. Mechanisms of alcohol toxicity (see Chapter 3 by Cederbaum)
  • 4. Lipotropes as a target of alcohol toxicity
  • 5. SAMe for chemoprevention in hepatocarcinogenesis
  • 6. Conclusion
  • References
  • 4. Methionine Adenosyltransferase and S-adenosylmethionine in Liver Health and Disease
  • 1. Introduction2. Historical perspective
  • 3. Hepatic methionine metabolism
  • 4. MAT genes and enzyme isoforms
  • 5. Abnormalities of MAT in liver disease
  • 6. Mechanisms of altered MAT gene expression in liver cirrhosis and cancer
  • 7. SAMe as control switch in maintaining normal liver function
  • 8. Importance of MAT and SAMe in liver diseaseâ€?lessons learned from the MAT1A null mice
  • 9. Concluding remarks
  • References
  • 5. Acetone Metabolism in the Liver: Two Approaches to the Same Phenomenon
  • 1. Introduction and history
  • 2. Metabolic pathways for acetone and role of liver3. Effects of acetone on biotransformation of xenobiotics
  • 4. Summary of clinical implications
  • 5. Possible pathophysiological role(s) of acetone biodegradation: two approaches to the same phenomenon
  • 6. Conclusion, perspectives and unanswered questions
  • References
  • 6. Oxidative Stress and Liver Fibrosis: From Liver Injury to Modulation of Cell Signalling and Response
  • 1. Introduction
  • 2. Oxidative stress, liver fibrosis, and chronic liver diseases: major concepts
  • 3. Major consequences of oxidative stress generation in relation to liver fibrosis and its progression4. Antioxidants: a possible tool to support conventional therapy for CLDs to reduce fibrosis progression?
  • 5. Concluding remarks
  • References
  • 7. Role of Nitric Oxide in Liver Disorders
  • 1. Introduction
  • 2. Nitric oxide and hepatic fibrosis
  • 3. Nitric oxide and hyperdynamic circulation
  • 4. Nitric oxide and paracetamol-induced liver injury
  • 5. Nitric oxide, and liver inflammation and septic shock

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