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Liver Diseases : Biochemical Mechanisms and New Therapeutic Insights.

This book presents state-of-art information summarizing the current understanding of a range of liver diseases, and reviews some key diagnostic and therapeutic advances. The book is a collection of selected clinical and scientific topics divided into two volumes, each divided into two sections. The...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Ali, Shakir
Otros Autores: Friedman, Scott L., Mann, Derek A.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Enfield : Science Publishers, 2006.
Temas:
Acceso en línea:Texto completo

MARC

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100 1 |a Ali, Shakir. 
245 1 0 |a Liver Diseases :  |b Biochemical Mechanisms and New Therapeutic Insights. 
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588 0 |a Print version record. 
505 0 |a Preface -- Contents -- About the Editors -- About the Authors -- Sectionâ€?I: Liver Diseases: Mediators and Regulation -- 1. Collagen Gene Regulation in the Hepatic Stellate Cell -- 1. Introduction -- 2. Molecular mechanisms controlling collagen synthesis -- 3. Mediators influencing collagen expression in HSCs -- 4. Posttranscriptional regulation of type I collagen expression -- References -- 2. CYP2E1â€?Biochemical and Toxicological Aspects and Role in Alcohol-induced Liver Injury -- 1. Introduction -- 2. CYP2E1 -- 3. CYP2E1 and alcohol-induced liver injury 
505 8 |a 4. Biochemical and toxicological properties of CYP2E1 in HEPG2 cells5. Future perspectives -- References -- 3. Alcohol and Methyl Transfer: Implications for Alcohol-related Hepatocarcinogenesis -- 1. Introduction -- 2. Alcohol-related hepatocarcinogenesis: A multi-step process -- 3. Mechanisms of alcohol toxicity (see Chapter 3 by Cederbaum) -- 4. Lipotropes as a target of alcohol toxicity -- 5. SAMe for chemoprevention in hepatocarcinogenesis -- 6. Conclusion -- References -- 4. Methionine Adenosyltransferase and S-adenosylmethionine in Liver Health and Disease 
505 8 |a 1. Introduction2. Historical perspective -- 3. Hepatic methionine metabolism -- 4. MAT genes and enzyme isoforms -- 5. Abnormalities of MAT in liver disease -- 6. Mechanisms of altered MAT gene expression in liver cirrhosis and cancer -- 7. SAMe as control switch in maintaining normal liver function -- 8. Importance of MAT and SAMe in liver diseaseâ€?lessons learned from the MAT1A null mice -- 9. Concluding remarks -- References -- 5. Acetone Metabolism in the Liver: Two Approaches to the Same Phenomenon -- 1. Introduction and history 
505 8 |a 2. Metabolic pathways for acetone and role of liver3. Effects of acetone on biotransformation of xenobiotics -- 4. Summary of clinical implications -- 5. Possible pathophysiological role(s) of acetone biodegradation: two approaches to the same phenomenon -- 6. Conclusion, perspectives and unanswered questions -- References -- 6. Oxidative Stress and Liver Fibrosis: From Liver Injury to Modulation of Cell Signalling and Response -- 1. Introduction -- 2. Oxidative stress, liver fibrosis, and chronic liver diseases: major concepts 
505 8 |a 3. Major consequences of oxidative stress generation in relation to liver fibrosis and its progression4. Antioxidants: a possible tool to support conventional therapy for CLDs to reduce fibrosis progression? -- 5. Concluding remarks -- References -- 7. Role of Nitric Oxide in Liver Disorders -- 1. Introduction -- 2. Nitric oxide and hepatic fibrosis -- 3. Nitric oxide and hyperdynamic circulation -- 4. Nitric oxide and paracetamol-induced liver injury -- 5. Nitric oxide, and liver inflammation and septic shock 
500 |a ""6. Nitric oxide and hepatic ischemia-reperfusion injury"" 
520 3 |a This book presents state-of-art information summarizing the current understanding of a range of liver diseases, and reviews some key diagnostic and therapeutic advances. The book is a collection of selected clinical and scientific topics divided into two volumes, each divided into two sections. The first volume treats the cellular, biochemical and immunological mechanisms underlying liver diseases; the second focuses on clinical liver disease pathophysiology and related diagnostics and therapeutic insights. It is hoped that the target readers - hepatologists, clinicians, researchers and cademicians - will be exposed to new ideas, and subjects beyond their own scientific disciplines. In addition, students and all those who wish to enlarge their knowledge of advances in the field of liver diseases will find this book a good source of information. 
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650 0 |a Liver  |x Diseases. 
650 0 |a Liver  |x Pathophysiology. 
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650 7 |a Liver  |x Pathophysiology  |2 fast 
700 1 |a Friedman, Scott L. 
700 1 |a Mann, Derek A. 
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