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Improving and Accelerating Therapeutic Development for Nervous System Disorders : Workshop Summary.
"Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Worksho...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Washington :
National Academies Press,
2014.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 003 | OCoLC | ||
| 005 | 20240329122006.0 | ||
| 006 | m o d | ||
| 007 | cr |n||||||||| | ||
| 008 | 151017s2014 dcu ob 000 0 eng d | ||
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| 019 | |a 961589534 |a 990392242 | ||
| 020 | |a 9780309292474 | ||
| 020 | |a 0309292476 | ||
| 020 | |a 0309292468 | ||
| 020 | |a 9780309292467 | ||
| 029 | 1 | |a DEBBG |b BV044185127 | |
| 035 | |a (OCoLC)923289754 |z (OCoLC)961589534 |z (OCoLC)990392242 | ||
| 050 | 4 | |a RM301.25.I47 2014eb | |
| 082 | 0 | 4 | |a 616.8046 |
| 049 | |a UAMI | ||
| 100 | 1 | |a Medicine, Institute of. | |
| 245 | 1 | 0 | |a Improving and Accelerating Therapeutic Development for Nervous System Disorders : |b Workshop Summary. |
| 260 | |a Washington : |b National Academies Press, |c 2014. | ||
| 300 | |a 1 online resource (119 pages) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |a FrontMatter -- Reviewers -- Contents -- 1 Introduction and Overview -- 2 Drug Development Challenges -- 3 Target Identification -- 4 Target Validation -- 5 Opportunities to Improve and Accelerate the Drug Development Pipeline -- 6 Perspectives on Next Steps -- Appendix A: References -- Appendix B: Workshop Agenda -- Appendix C: Registered Attendees | |
| 546 | |a English. | ||
| 504 | |a Includes bibliographical references. | ||
| 520 | |a "Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials."-- |c Publisher's website. | ||
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Drug development |x Research. | |
| 650 | 0 | |a Neuropharmacology |x Testing. | |
| 650 | 0 | |a Drugs |x Research. | |
| 650 | 0 | |a Clinical trials. | |
| 650 | 0 | |a Neurosciences. | |
| 650 | 0 | |a Pharmaceutical chemistry. | |
| 650 | 0 | |a Chemotherapy. | |
| 650 | 0 | |a Diseases. | |
| 650 | 0 | |a Therapeutics. | |
| 650 | 0 | |a Chemistry. | |
| 650 | 0 | |a Pharmacology. | |
| 650 | 0 | |a Physical sciences. | |
| 650 | 0 | |a Public health. | |
| 650 | 0 | |a Life sciences. | |
| 650 | 0 | |a Medical care. | |
| 650 | 0 | |a Nervous system |x Diseases. | |
| 650 | 2 | |a Chemistry, Pharmaceutical | |
| 650 | 2 | |a Epidemiologic Study Characteristics as Topic | |
| 650 | 2 | |a Investigative Techniques | |
| 650 | 2 | |a Drug Therapy | |
| 650 | 2 | |a Disease | |
| 650 | 2 | |a Evaluation Studies as Topic | |
| 650 | 2 | |a Therapeutics | |
| 650 | 2 | |a Epidemiologic Methods | |
| 650 | 2 | |a Health Care Evaluation Mechanisms | |
| 650 | 2 | |a Chemistry | |
| 650 | 2 | |a Pharmacology | |
| 650 | 2 | |a Analytical, Diagnostic and Therapeutic Techniques and Equipment | |
| 650 | 2 | |a Natural Science Disciplines | |
| 650 | 2 | |a Public Health | |
| 650 | 2 | |a Biological Science Disciplines | |
| 650 | 2 | |a Quality of Health Care | |
| 650 | 2 | |a Health Care Quality, Access, and Evaluation | |
| 650 | 2 | |a Disciplines and Occupations | |
| 650 | 2 | |a Environment and Public Health | |
| 650 | 2 | |a Delivery of Health Care | |
| 650 | 2 | |a Models, Animal | |
| 650 | 2 | |a Clinical Trials as Topic | |
| 650 | 2 | |a Drug Delivery Systems | |
| 650 | 2 | |a Nervous System Diseases | |
| 650 | 2 | |a Drug Discovery | |
| 650 | 2 | |a Neurosciences | |
| 650 | 2 | |a Patient Care | |
| 650 | 6 | |a Médicaments |x Développement |x Recherche. | |
| 650 | 6 | |a Médicaments |x Recherche. | |
| 650 | 6 | |a Études cliniques. | |
| 650 | 6 | |a Neurosciences. | |
| 650 | 6 | |a Chimie pharmaceutique. | |
| 650 | 6 | |a Chimiothérapie. | |
| 650 | 6 | |a Maladies. | |
| 650 | 6 | |a Thérapeutique. | |
| 650 | 6 | |a Chimie. | |
| 650 | 6 | |a Pharmacologie. | |
| 650 | 6 | |a Sciences physiques. | |
| 650 | 6 | |a Santé publique. | |
| 650 | 6 | |a Sciences de la vie. | |
| 650 | 6 | |a Prestation de soins. | |
| 650 | 6 | |a Système nerveux |x Maladies. | |
| 650 | 6 | |a Soins médicaux. | |
| 650 | 7 | |a illness. |2 aat | |
| 650 | 7 | |a disease. |2 aat | |
| 650 | 7 | |a chemistry. |2 aat | |
| 650 | 7 | |a pharmacology. |2 aat | |
| 650 | 7 | |a physical sciences. |2 aat | |
| 650 | 7 | |a public health. |2 aat | |
| 650 | 7 | |a biological sciences. |2 aat | |
| 650 | 7 | |a treating (health care function) |2 aat | |
| 650 | 7 | |a Therapeutics |2 fast | |
| 650 | 7 | |a Public health |2 fast | |
| 650 | 7 | |a Physical sciences |2 fast | |
| 650 | 7 | |a Pharmacology |2 fast | |
| 650 | 7 | |a Pharmaceutical chemistry |2 fast | |
| 650 | 7 | |a Nervous system |x Diseases |2 fast | |
| 650 | 7 | |a Medical care |2 fast | |
| 650 | 7 | |a Life sciences |2 fast | |
| 650 | 7 | |a Diseases |2 fast | |
| 650 | 7 | |a Chemotherapy |2 fast | |
| 650 | 7 | |a Chemistry |2 fast | |
| 650 | 7 | |a Clinical trials |2 fast | |
| 650 | 7 | |a Drugs |x Research |2 fast | |
| 650 | 7 | |a Neurosciences |2 fast | |
| 700 | 1 | |a Policy, Board on Health Sciences. | |
| 700 | 1 | |a Disorders, Forum on Neuroscience and Nervous System. | |
| 758 | |i has work: |a Improving and Accelerating Therapeutic Development for Nervous System Disorders (Text) |1 https://id.oclc.org/worldcat/entity/E39PCXtbJc37WQMCXwHHtTw9Qm |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
| 776 | 0 | 8 | |i Print version: |a Medicine, Institute of. |t Improving and Accelerating Therapeutic Development for Nervous System Disorders : Workshop Summary. |d Washington : National Academies Press, ©1900 |z 9780309292467 |
| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=3379237 |z Texto completo |
| 938 | |a EBL - Ebook Library |b EBLB |n EBL3379237 | ||
| 994 | |a 92 |b IZTAP | ||