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OCoLC |
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20240329122006.0 |
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m o d |
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151010s1900 dcu o 000 0 eng d |
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|a EBLCP
|b eng
|e pn
|c EBLCP
|d OCLCQ
|d MERUC
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|a 9780309557696
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|a 0309557690
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|a DEBBG
|b BV044107898
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|a (OCoLC)923269214
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|a n-us---
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|a RA
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|a 333.9122
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|a UAMI
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| 100 |
1 |
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|a Staff, National Research Council.
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| 245 |
1 |
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|a Drinking Water and Health, Volume 8 :
|b Pharmacokinetics in Risk Assessment.
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| 260 |
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|a Washington :
|b National Academies Press,
|c 1900.
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| 300 |
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|a 1 online resource (512 pages)
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 588 |
0 |
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|a Print version record.
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| 505 |
0 |
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|a ""Pharmacokinetics in Risk Assessment""; ""Copyright""; ""PREFACE""; ""Contents""; ""PART I INTRODUCTION: THE PROBLEM AND AN APPROACH ""; ""Risk Assessment: Historical Perspectives""; ""References""; ""Tissue Dosimetry in Risk Assessment, or What's the Problem Here Anyway?""; ""INTRODUCTION""; ""A DOSE OF WHAT?""; ""ISN'T THIS VOLUME ABOUT PHARMACOKINETICS?""; ""GENOTOXIC CARCINOGENS""; ""PARENT CHEMICAL""; ""STABLE METABOLITES""; ""REACTIVE, NONISOLATABLE METABOLITES""; ""INTERCALATING AGENTS""; ""EPIGENETIC CARCINOGENS""; ""SUMMARY""; ""References""; ""PART II MATHEMATICAL MODELING ""
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| 505 |
8 |
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|a ""Modeling: An Introduction""""References""; ""Physiologically Based Pharmacokinetic Modeling""; ""INTRODUCTION""; ""BIOLOGICAL BASIS OF PHYSIOLOGICAL PHARMACOKINETICS""; ""DEVELOPMENT OF MODELS""; ""CHOICE OF COMPARTMENTS""; ""BASIC MASS BALANCES""; ""Mass Balance: Blood Pool""; ""Mass Balance: Tissue Region i""; ""SIMPLIFICATIONS OF MASS BALANCES""; ""Examples""; ""DISCUSSION""; ""FUTURE RESEARCH NEEDS""; ""References""; ""PART III GENERALIZATIONS AND EXTRAPOLATIONS ""; ""Allometry: Body Size Constraints in Animal Design""; ""INTRODUCTION""; ""SIZE, DESIGN, AND PHARMACOKINETICS""
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| 505 |
8 |
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|a ""Aerobic Energetics of Muscle In Vivo""""Conflict of Physiological and Chronological Time""; ""Species Extrapolations, Physiological Time, and Pharmacokinetics""; ""CONCLUSIONS""; ""SUMMARY""; ""References""; ""Prediction of In Vivo Parameters of Drug Metabolism and Distribution from In Vitro Studies""; ""IN VITRO PREDICTION OF IN VIVO DRUG METABOLISM""; ""IN VITRO PREDICTION OF IN VIVO DRUG BINDING AND DISTRIBUTION""; ""CONCLUSION""; ""References""; ""Dose, Species, and Route Extrapolation: General Aspects""; ""DIFFERENT PROBLEMS AND OBJECTIVES, DIFFERENT MODELS""; ""Different Mechanisms""
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| 505 |
8 |
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|a ""GENERAL PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELS""""Simplification of Models""; ""Rates of Formation of Complexes""; ""Diffusional Barriers and Modified Fick's Law""; ""Simple PB-PK Models""; ""Basic Parameters fu and R""; ""Nonlinear Kinetics and Lost Concepts""; ""INTERFACE BETWEEN PB-PK MODELS AND CLEARANCES""; ""Organ Availabilities (F), Extraction Ratios (E), and Clearances (CL)""; ""Physiologically Based Linear Compartmental Pharmacokinetic Models""; ""Validity of the Assumption of Virtual Steady State""; ""Calculation of Other Compartmental Model Parameters""
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| 505 |
8 |
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|a ""Approximations of Terminal Half-Lives""""Approximate Time Required to Approach Steady State""; ""LINEAR PHARMACOKINETIC SYSTEMS""; ""Total Body Clearance""; ""Importance of the Unbound Concentration of Substances""; ""Classification of Organs; Routes of Administration""; ""Non-First-Pass, Nonelimination Organs""; ""Range of Maximum and Minimum Unbound Concentrations in Nonelimination Organs and Repetitive Administration""; ""Non-First-Pass, Elimination Organs""; ""FIRST-PASS, NONELIMINATION ORGANS""; ""First-Pass, Elimination Organs""; ""ROUTE-TO-ROUTE EXTRAPOLATION""
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| 500 |
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|a ""Lungs and Skin Administration""
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| 590 |
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|a ProQuest Ebook Central
|b Ebook Central Academic Complete
|
| 650 |
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0 |
|a Drinking water
|x Contamination
|z United States.
|
| 650 |
|
0 |
|a Drinking water
|x Contamination.
|
| 650 |
|
0 |
|a Drinking water
|x Health aspects
|z United States.
|
| 650 |
|
0 |
|a Drinking water
|x Health aspects.
|
| 650 |
|
0 |
|a Water
|x Pollution
|x Toxicology.
|
| 650 |
|
6 |
|a Eau potable
|x Contamination
|z États-Unis.
|
| 650 |
|
6 |
|a Eau potable
|x Contamination.
|
| 650 |
|
7 |
|a Drinking water
|x Contamination
|2 fast
|
| 650 |
|
7 |
|a Drinking water
|x Health aspects
|2 fast
|
| 650 |
|
7 |
|a Water
|x Pollution
|x Toxicology
|2 fast
|
| 651 |
|
7 |
|a United States
|2 fast
|1 https://id.oclc.org/worldcat/entity/E39PBJtxgQXMWqmjMjjwXRHgrq
|
| 700 |
1 |
|
|a Committee, Safe Drinking Water.
|
| 758 |
|
|
|i has work:
|a Drinking Water and Health, Volume 8 (Text)
|1 https://id.oclc.org/worldcat/entity/E39PD3jwcp6jXqRDFfcHdpJv73
|4 https://id.oclc.org/worldcat/ontology/hasWork
|
| 776 |
0 |
8 |
|i Print version:
|a Staff, National Research Council.
|t Drinking Water and Health, Volume 8 : Pharmacokinetics in Risk Assessment.
|d Washington : National Academies Press, ©1900
|z 9780309037754
|
| 856 |
4 |
0 |
|u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=3377244
|z Texto completo
|
| 938 |
|
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|a ProQuest Ebook Central
|b EBLB
|n EBL3377244
|
| 994 |
|
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|a 92
|b IZTAP
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