Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity.

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Toxicity, Subcommittee on Reproductive and Developmental
Otros Autores: Staff, National Research Council
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Washington : National Academies Press, 2001.
Colección:Compass series (Washington, D.C.)
Temas:
Reproductive toxicology.
Developmental toxicology.
Toxicity testing.
Pollutants.
Teratogenic agents.
Abnormalities, Human.
Pollution.
Public health.
Diseases.
Medical care.
Environmental Pollutants
Reproduction
Environmental Exposure
Teratogens
Abnormalities, Drug-Induced
Congenital Abnormalities
Reproductive Physiological Phenomena
Environmental Pollution
Toxic Actions
Noxae
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Chemical Actions and Uses
Public Health
Environment and Public Health
Chemicals and Drugs
Disease
Reproductive and Urinary Physiological Phenomena
Delivery of Health Care
Phenomena and Processes
Patient Care
Toxicologie de la reproduction.
Toxicologie du développement.
Polluants.
Exposition (Toxicologie)
Agents tératogènes.
Malformations.
Santé publique.
Maladies.
Prestation de soins.
Soins médicaux.
pollutants.
public health.
Teratogenic agents
Public health
Pollution
Pollutants
Medical care
Diseases
Abnormalities, Human
Developmental toxicology
Reproductive toxicology
Toxicity testing
Acceso en línea:Texto completo
Tabla de Contenidos:
  • EVALUATING CHEMICAL AND OTHER AGENT EXPOSURES FOR REPRODUCTIVE AND DEVELOPMENTAL TOXICITY
  • Copyright
  • Preface
  • Contents
  • Abbreviations
  • EVALUATING CHEMICAL AND OTHER AGENT EXPOSURES FOR REPRODUCTIVE AND DEVELOPMENTAL TOXICITY
  • Summary
  • CONCLUSIONS AND RECOMMENDATIONS
  • Evaluative Process
  • Assessing the Available Data
  • Integration of Toxicity and Exposure Information
  • Insufficient Data Sets
  • Application of the Evaluative Process
  • Sources of Information
  • Research Recommendations
  • 1 Introduction
  • SUBCOMMITTEE'S TASK
  • ORGANIZATION OF THE REPORT2 The Evaluative Process: Part I. Assessing the Available Data
  • PRINCIPLES AND OBJECTIVES
  • Use of Data and Judgment
  • Weight of Evidence
  • Threshold Assumption
  • Narrative Statement
  • Certainty
  • Use All Relevant, Acceptable Data
  • Qualities and Limitations of Reproductive and Developmental Toxicity Studies
  • Characterizing Data
  • Expert Review Team
  • GENERAL DESCRIPTION
  • DETAILS OF THE EVALUATIVE PROCESS
  • Exposure Data
  • General Toxicological and Biological Parameters
  • Chemistry
  • Basic Toxicity
  • Acute StudiesRepeated-Dose Studies
  • Genetic Toxicity
  • Pharmacokinetics
  • Reproductive and Developmental Toxicity
  • Human Data
  • Weighing the Evidence
  • Case Reports and Clinical Series
  • Assessing Causality in Human Studies
  • Experimental Animal Toxicity
  • Utility and Limitations
  • Adverse Effect
  • 3 The Evaluative Process: Part II. Integration of Toxicity and Exposure Information
  • INTERPRETATION OF TOXICITY DATA
  • Default Assumptions To Be Considered in Assessing Reproductive and Developmental Toxicity Risk
  • Absorption
  • Cross-Species ExtrapolationExposure Duration
  • Windows of Vulnerability
  • Additivity
  • QUANTITATIVE EVALUATION
  • Identification of the NOAEL and LOAEL
  • Calculation of the Benchmark Dose
  • Duration Adjustment
  • Uncertainty Factors
  • Calculation of the Unlikely Effect Level
  • Calculation of the Margin of Exposure (MOE)
  • Assessing a Degree of Concern
  • Application of Reproductive and Developmental Toxicity Data to Various Exposure Scenarios
  • Critical Data Needs
  • SUMMARY
  • 4 Incomplete or Insufficient Data Sets
  • PRINCIPLES TO MINIMIZE RISKPRACTICAL APPLICATION
  • REDUCING UNCERTAINTY
  • 5 Recommendations
  • GENERAL RECOMMENDATIONS
  • RESEARCH RECOMMENDATIONS
  • References
  • Appendixes
  • Appendix A Application of the Recommended Evaluative Process to Specific Chemicals
  • JP-8 JET FUEL
  • Exposure Data
  • General Toxicological and Biological Parameters
  • Lethality
  • Acute Studies
  • Human Studies
  • Experimental Animal Studies
  • Repeated-Dose Studies
  • Human Studies
  • Experimental Animal Studies
  • Cancer
  • Genetic Toxicity

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