|
|
|
|
| LEADER |
00000cam a2200000 4500 |
| 001 |
EBOOKCENTRAL_ocn923269014 |
| 003 |
OCoLC |
| 005 |
20240329122006.0 |
| 006 |
m o d |
| 007 |
cr |n||||||||| |
| 008 |
151010s2001 dcu ob 000 0 eng d |
| 040 |
|
|
|a EBLCP
|b eng
|e pn
|c EBLCP
|d OCLCQ
|d MERUC
|d OCLCQ
|d XFH
|d OCLCF
|d OCLCQ
|d NJR
|d OCLCO
|d ZCU
|d OCLCO
|d OCLCA
|d U3W
|d OCLCO
|d OCLCQ
|d OCLCO
|d ICG
|d AU@
|d OCLCQ
|d OCLCA
|d LVT
|d OCLCA
|d DKC
|d OCLCQ
|d OCLCO
|d OCLCQ
|d UKBTH
|d OCLCQ
|d OCLCA
|d OCLCQ
|d OCLCA
|d OCLCO
|d OCLCQ
|d OCL
|d OCLCO
|
| 019 |
|
|
|a 994400892
|a 1058521996
|a 1097134677
|a 1229427874
|
| 020 |
|
|
|a 9780309567619
|
| 020 |
|
|
|a 0309567610
|
| 020 |
|
|
|a 0309073162
|
| 020 |
|
|
|a 9780309073165
|
| 020 |
|
|
|a 1280185090
|
| 020 |
|
|
|a 9781280185090
|
| 020 |
|
|
|a 9786610185092
|
| 020 |
|
|
|a 6610185093
|
| 029 |
1 |
|
|a DEBBG
|b BV044107860
|
| 035 |
|
|
|a (OCoLC)923269014
|z (OCoLC)994400892
|z (OCoLC)1058521996
|z (OCoLC)1097134677
|z (OCoLC)1229427874
|
| 043 |
|
|
|a n-us---
|
| 050 |
|
4 |
|a RA1224.2.N385 2001eb
|
| 082 |
0 |
4 |
|a 616.65071
|
| 049 |
|
|
|a UAMI
|
| 100 |
1 |
|
|a Toxicity, Subcommittee on Reproductive and Developmental.
|
| 245 |
1 |
0 |
|a Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity.
|
| 260 |
|
|
|a Washington :
|b National Academies Press,
|c 2001.
|
| 300 |
|
|
|a 1 online resource (262 pages)
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 490 |
1 |
|
|a The compass series
|
| 588 |
0 |
|
|a Print version record.
|
| 505 |
0 |
|
|a EVALUATING CHEMICAL AND OTHER AGENT EXPOSURES FOR REPRODUCTIVE AND DEVELOPMENTAL TOXICITY -- Copyright -- Preface -- Contents -- Abbreviations -- EVALUATING CHEMICAL AND OTHER AGENT EXPOSURES FOR REPRODUCTIVE AND DEVELOPMENTAL TOXICITY -- Summary -- CONCLUSIONS AND RECOMMENDATIONS -- Evaluative Process -- Assessing the Available Data -- Integration of Toxicity and Exposure Information -- Insufficient Data Sets -- Application of the Evaluative Process -- Sources of Information -- Research Recommendations -- 1 Introduction -- SUBCOMMITTEE'S TASK
|
| 505 |
8 |
|
|a ORGANIZATION OF THE REPORT2 The Evaluative Process: Part I. Assessing the Available Data -- PRINCIPLES AND OBJECTIVES -- Use of Data and Judgment -- Weight of Evidence -- Threshold Assumption -- Narrative Statement -- Certainty -- Use All Relevant, Acceptable Data -- Qualities and Limitations of Reproductive and Developmental Toxicity Studies -- Characterizing Data -- Expert Review Team -- GENERAL DESCRIPTION -- DETAILS OF THE EVALUATIVE PROCESS -- Exposure Data -- General Toxicological and Biological Parameters -- Chemistry -- Basic Toxicity
|
| 505 |
8 |
|
|a Acute StudiesRepeated-Dose Studies -- Genetic Toxicity -- Pharmacokinetics -- Reproductive and Developmental Toxicity -- Human Data -- Weighing the Evidence -- Case Reports and Clinical Series -- Assessing Causality in Human Studies -- Experimental Animal Toxicity -- Utility and Limitations -- Adverse Effect -- 3 The Evaluative Process: Part II. Integration of Toxicity and Exposure Information -- INTERPRETATION OF TOXICITY DATA -- Default Assumptions To Be Considered in Assessing Reproductive and Developmental Toxicity Risk -- Absorption
|
| 505 |
8 |
|
|a Cross-Species ExtrapolationExposure Duration -- Windows of Vulnerability -- Additivity -- QUANTITATIVE EVALUATION -- Identification of the NOAEL and LOAEL -- Calculation of the Benchmark Dose -- Duration Adjustment -- Uncertainty Factors -- Calculation of the Unlikely Effect Level -- Calculation of the Margin of Exposure (MOE) -- Assessing a Degree of Concern -- Application of Reproductive and Developmental Toxicity Data to Various Exposure Scenarios -- Critical Data Needs -- SUMMARY -- 4 Incomplete or Insufficient Data Sets
|
| 505 |
8 |
|
|a PRINCIPLES TO MINIMIZE RISKPRACTICAL APPLICATION -- REDUCING UNCERTAINTY -- 5 Recommendations -- GENERAL RECOMMENDATIONS -- RESEARCH RECOMMENDATIONS -- References -- Appendixes -- Appendix A Application of the Recommended Evaluative Process to Specific Chemicals -- JP-8 JET FUEL -- Exposure Data -- General Toxicological and Biological Parameters -- Lethality -- Acute Studies -- Human Studies -- Experimental Animal Studies -- Repeated-Dose Studies -- Human Studies -- Experimental Animal Studies -- Cancer -- Genetic Toxicity
|
| 500 |
|
|
|a ""Disposition and Pharmacokinetics""
|
| 546 |
|
|
|a English.
|
| 504 |
|
|
|a Includes bibliographical references (pages 92-114).
|
| 590 |
|
|
|a ProQuest Ebook Central
|b Ebook Central Academic Complete
|
| 650 |
|
0 |
|a Reproductive toxicology.
|
| 650 |
|
0 |
|a Developmental toxicology.
|
| 650 |
|
0 |
|a Toxicity testing.
|
| 650 |
|
0 |
|a Pollutants.
|
| 650 |
|
0 |
|a Teratogenic agents.
|
| 650 |
|
0 |
|a Abnormalities, Human.
|
| 650 |
|
0 |
|a Pollution.
|
| 650 |
|
0 |
|a Public health.
|
| 650 |
|
0 |
|a Diseases.
|
| 650 |
|
0 |
|a Medical care.
|
| 650 |
|
2 |
|a Environmental Pollutants
|
| 650 |
|
2 |
|a Reproduction
|
| 650 |
|
2 |
|a Environmental Exposure
|
| 650 |
|
2 |
|a Teratogens
|
| 650 |
|
2 |
|a Abnormalities, Drug-Induced
|
| 650 |
|
2 |
|a Congenital Abnormalities
|
| 650 |
|
2 |
|a Reproductive Physiological Phenomena
|
| 650 |
|
2 |
|a Environmental Pollution
|
| 650 |
|
2 |
|a Toxic Actions
|
| 650 |
|
2 |
|a Noxae
|
| 650 |
|
2 |
|a Congenital, Hereditary, and Neonatal Diseases and Abnormalities
|
| 650 |
|
2 |
|a Chemical Actions and Uses
|
| 650 |
|
2 |
|a Public Health
|
| 650 |
|
2 |
|a Environment and Public Health
|
| 650 |
|
2 |
|a Chemicals and Drugs
|
| 650 |
|
2 |
|a Disease
|
| 650 |
|
2 |
|a Reproductive and Urinary Physiological Phenomena
|
| 650 |
|
2 |
|a Delivery of Health Care
|
| 650 |
|
2 |
|a Phenomena and Processes
|
| 650 |
|
2 |
|a Patient Care
|
| 650 |
|
6 |
|a Toxicologie de la reproduction.
|
| 650 |
|
6 |
|a Toxicologie du développement.
|
| 650 |
|
6 |
|a Polluants.
|
| 650 |
|
6 |
|a Exposition (Toxicologie)
|
| 650 |
|
6 |
|a Agents tératogènes.
|
| 650 |
|
6 |
|a Malformations.
|
| 650 |
|
6 |
|a Pollution.
|
| 650 |
|
6 |
|a Santé publique.
|
| 650 |
|
6 |
|a Maladies.
|
| 650 |
|
6 |
|a Prestation de soins.
|
| 650 |
|
6 |
|a Soins médicaux.
|
| 650 |
|
7 |
|a pollutants.
|2 aat
|
| 650 |
|
7 |
|a public health.
|2 aat
|
| 650 |
|
7 |
|a Teratogenic agents
|2 fast
|
| 650 |
|
7 |
|a Public health
|2 fast
|
| 650 |
|
7 |
|a Pollution
|2 fast
|
| 650 |
|
7 |
|a Pollutants
|2 fast
|
| 650 |
|
7 |
|a Medical care
|2 fast
|
| 650 |
|
7 |
|a Diseases
|2 fast
|
| 650 |
|
7 |
|a Abnormalities, Human
|2 fast
|
| 650 |
|
7 |
|a Developmental toxicology
|2 fast
|
| 650 |
|
7 |
|a Reproductive toxicology
|2 fast
|
| 650 |
|
7 |
|a Toxicity testing
|2 fast
|
| 700 |
1 |
|
|a Staff, National Research Council.
|
| 776 |
0 |
8 |
|i Print version:
|a Toxicity, Subcommittee on Reproductive and Developmental.
|t Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity.
|d Washington : National Academies Press, ©1900
|z 9780309073165
|
| 830 |
|
0 |
|a Compass series (Washington, D.C.)
|
| 856 |
4 |
0 |
|u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=3377205
|z Texto completo
|
| 936 |
|
|
|a BATCHLOAD
|
| 938 |
|
|
|a ProQuest Ebook Central
|b EBLB
|n EBL3377205
|
| 994 |
|
|
|a 92
|b IZTAP
|
