Cargando…
Toxicity Testing : Strategies to Determine Needs and Priorities.
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Washington :
National Academies Press,
1900.
|
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- ""Toxicity Testing""; ""Copyright""; ""PREFACE""; ""ACKNOWLEDGMENTS""; ""Contents""; ""EXECUTIVE SUMMARY""; ""SELECT UNIVERSE OF SUBSTANCES""; ""CHARACTERIZING TOXICITY-TESTING NEEDS""; ""QUANTITY AND NATURE OF TESTING""; ""QUALITY OF TESTING""; ""TOXICITY-TESTING NEEDS""; ""HEALTH-HAZARD ASSESSMENT""; ""INTERPRETATION OF PHYSICOCHEMICAL AND EXPOSURE DATA""; ""APPROACHES TO PRIORITY-SETTING""; ""INTRODUCTION""; ""THE NATIONAL TOXICOLOGY PROGRAM""; ""THE STUDY""; ""REFERENCES""; ""PART 1 TOXICITY-TESTING NEEDS IN THE SELECT UNIVERSE ""; ""Contents""; ""1 Introduction ""
- ""2 Sample Selection """"THE UNIVERSE AND THE SAMPLING FRAME""; ""Pesticides and Inert Ingredients of Pesticide Formulations""; ""Cosmetic Ingredients""; ""Drugs and Excipients in Drug Formulations""; ""Food Additives""; ""Chemicals in Commerce""; ""CONSIDERATIONS IN DEVELOPING THE SAMPLING STRATEGY""; ""SAMPLING STRATEGY""; ""Sample Size""; ""Sampling Plan""; ""SCREENING THE SAMPLE FOR MINIMAL TOXICITY INFORMATION""; ""3 Operating Policies for Identification, Acquisition, and Organization of Data ""; ""RESTRICTED-ACCESS OR CONFIDENTIAL INFORMATION""; ""INFORMATION ON TOXICITY IN HUMANS""
- ""CHEMICAL AND PHYSICAL CHARACTERISTICS, MANUFACTURING PROCESSES, PRODUCTION VOLUMES, INTENDED USES AND�""""CHEMICAL REVIEW ARTICLES""; ""ARTICLES IN FOREIGN LANGUAGES""; ""SUBSTANCES STRUCTURALLY SIMILAR TO THOSE IN THE SAMPLE""; ""4 Data Evaluation ""; ""THE DOSSIER CONCEPT""; ""GENERAL PRINCIPLES FOR EVALUATION OF TOXICITY-TESTING PROTOCOLS""; ""CONSIDERATION OF EXPOSURE""; ""PURITY OF SELECTED SUBSTANCES""; ""GUIDELINES FOR ASSESSING THE QUALITY OF INDIVIDUAL STUDIES""; ""Basic Criteria for Scientific Methods""; ""Selection of Reference Protocols""
- ""Reference Protocol Guidelines for Neurobehavioral-Toxicity Tests""""Reference Protocol Guidelines for Genetic-Toxicity Tests""; ""PROCEDURES FOR EVALUATION OF THE DATA BASE""; ""Initial Considerations""; ""Adequacy Ratings""; ""Measures of Adequacy for Tests Not Meeting the Reference Protocol Guidelines""; ""Dossier Review Process""; ""LIMITATIONS OF THE DATA GATHERING PROCESS""; ""INTERPRETATION OF DATA ON TESTING QUALITY""; ""CHARACTERIZING THE SAMPLE AND OPTIONS FOR DRAWING INFERENCES TO THE SELECT UNIVERSE""; ""Construction of Tables for Analysis""; ""Statistical Analysis of Data""
- ""Estimates Based on the Sample Alone""""Estimates Based on the Subsample Alone""; ""Estimates Based on Both the Sample and the Subsample""; ""MACHINE-READABLE FILES""; ""5 Results ""; ""QUANTITY AND NATURE OF TESTING""; ""Sample of 675 Substances""; ""Subsample of 100 Substances""; ""QUALITY OF TESTING""; ""TESTING NEEDS""; ""HEALTH-HAZARD ASSESSMENT""; ""INTERPRETATION AND ANALYSIS OF PHYSICOCHEMICAL AND EXPOSURE DATA""; ""6 Summary and Conclusions ""; ""REFERENCES""; ""Appendix A Sample of 675 Substances and Subsample of 100 Substances from the ''Select Universe'' ""