Assessment of Future Scientific Needs for Live Variola Virus.

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Staff, Institute of Medicine
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Washington : National Academies Press, 1999.
Colección:The compass series Assessment of future scientific needs for live variola virus
Temas:
Smallpox > Research.
Smallpox > Prevention.
Smallpox vaccine > Cultures and culture media.
Virology.
Science.
Physical sciences.
Virus diseases.
DNA viruses.
Diseases.
Viruses.
Research.
Investigative Techniques
Science
Orthopoxvirus
Poxviridae Infections
DNA Virus Infections
Chordopoxvirinae
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Natural Science Disciplines
Virus Diseases
Disciplines and Occupations
Poxviridae
DNA Viruses
Disease
Viruses
Vertebrate Viruses
Organisms
Variola virus
Research
Smallpox
Containment of Biohazards
Virology
Variole > Recherche.
Variole > Prévention.
Vaccin antivariolique > Cultures et milieux de culture.
Virologie.
Sciences.
Sciences physiques.
Maladies à virus.
Virus à ADN.
Maladies.
Virus.
Recherche.
sciences (philosophy)
physical sciences.
research (function)
science (modern discipline)
Virus diseases
Physical sciences
DNA viruses
Diseases
Smallpox > Prevention
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Assessment of Future Scientific Needs for Live Variola Virus
  • Copyright
  • Preface
  • Acknowledgments
  • REVIEWERS
  • Contents
  • Executive Summary
  • SCOPE
  • SCIENTIFIC NEEDS FOR LIVE AND REPLICATION-DEFECTIVE VARIOLA VIRUS
  • OVERALL CONCLUSIONS
  • Part I Introduction
  • 1 Introduction
  • BACKGROUND
  • CONTEMPORARY CONTEXT
  • SCOPE
  • SCIENTIFIC NEEDS FOR VARIOLA VIRUS
  • ORGANIZATION OF THIS REPORT
  • Part II Smallpox and Its Control
  • 2 Variola Virus and Other Orthopoxviruses
  • GENERAL ATTRIBUTES OF ORTHOPOXVIRUSES
  • POXVIRUS REPLICATIONPROPERTIES OF SPECIFIC ORTHOPOXVIRUSES
  • 3 Clinical Features of Smallpox
  • ENTRY AND INFECTION
  • DISSEMINATION
  • THE RASH
  • LESIONS OF THE MUCOUS MEMBRANES
  • EFFECTS ON OTHER ORGANS
  • IMMUNE RESPONSE
  • IMMUNITY AGAINST SMALLPOX
  • 4 Epidemiology
  • CHARACTERISTICS OF HISTORICAL OUTBREAKS
  • LIKELY CHARACTERISTICS OF FUTURE SMALLPOX OUTBREAKS
  • CONTROL STRATEGIES
  • 5 Variola Virus Stocks Following Eradication of Smallpox
  • ESTABLISHMENT OF INTERNATIONAL REPOSITORIES
  • DECISION BY THE WORLD HEALTH ASSEMBLY TO DESTROY VARIOLA VIRUS STOCKSU.S. RESEARCH ON SMALLPOX
  • RESEARCH AT CDC AND USAMRIID
  • Part III Scientific Needs for Variola Virus
  • 6 Development of Antiviral Agents
  • IN VITRO ASSAYS
  • ANIMAL MODELS
  • 7 Development of Vaccines
  • CURRENT STATUS OF VACCINIA VACCINE PREPARATIONS
  • EVALUATION OF VACCINIA VACCINE DERIVED FROM TISSUE CULTURE
  • EVALUATION OF NOVEL VACCINES
  • 8 Detection and Diagnosis
  • ENVIRONMENTAL DETECTION
  • DIAGNOSIS OF INFECTION
  • ALTERNATIVES TO LIVE VIRUS
  • 9 Bioinformatics
  • VARIABILITY OF VARIOLA VIRUSPOTENTIAL DEVELOPMENTS
  • 10 Understanding of the Biology of Variola Virus
  • VIRUS-CELL INTERACTIONS
  • VIRUS-HOST INTERACTIONS
  • 11 Research on the Expressed Protein Products of Variola
  • SYNTHESIS OF VARIOLA PROTEINS
  • POTENTIAL UTILITY OF VARIOLA PROTEINS
  • Part IV Findings
  • 12 Summary and Conclusions
  • THE BROADER CONTEXT
  • SCIENTIFIC NEEDS FOR LIVE VARIOLA VIRUS
  • OVERALL CONCLUSIONS
  • References
  • Appendix A Glossary
  • Appendix B Acronyms
  • Appendix C Committee and Staff Biographies
  • Staff

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