Tabla de Contenidos:
  • ""PESTICIDES in the DIETS OF INFANTS AND CHILDREN""; ""Copyright""; ""Preface""; ""Contents""; ""Executive Summary""; ""CONCLUSIONS""; ""Age-Related Variation in Susceptibility and Toxicity""; ""Age-Related Differences in Exposure""; ""A New Approach to Risk Assessment for Infants and Children""; ""RECOMMENDATIONS""; ""1 Background and Approach to the Study ""; ""PESTICIDE USE""; ""PESTICIDE CONTROL LEGISLATION""; ""APPROACH TO THE STUDY""; ""REFERENCES""; ""2 Special Characteristics of Children ""; ""GROWTH""; ""Normal Human Growth""; ""Human Compared to Animal Infants""
  • ""Toxicologic Implications of Growth in Cell Numbers and Size""""Toxicologic Implications of the Growth and Development of Organs""; ""Toxicologic Implications of Changes in Body Composition""; ""DEVELOPMENT""; ""Genetics, Development, and the Environment""; ""Metabolism""; ""Developmental Toxicity Studies""; ""CONCLUSIONS AND RECOMMENDATIONS""; ""Conclusions""; ""Recommendations""; ""REFERENCES""; ""3 Perinatal and Pediatric Toxicity ""; ""ACUTE TOXICITY""; ""NEUROTOXICITY""; ""Postnatal Effects of Neurotoxicants""; ""Measuring Neurotoxic Effects in Humans""; ""The Lead Model""
  • ""Pesticides as Neurotoxicants""""Effects of Pesticides in Children""; ""Levels of Pesticides Affecting Children""; ""Comparability of Neurotoxicity Effects in Laboratory Animals""; ""IMMUNOTOXICITY""; ""Effects of Environmental Agents on the Immune System""; ""Animal Studies""; ""Studies in Humans""; ""CARCINOGENESIS AND MUTAGENESIS""; ""Carcinogenesis in the Developing Organism""; ""Animal Studies""; ""Human Studies""; ""METABOLISM AND PHARMACOKINETICS""; ""Dermal and Pulmonary Exposure""; ""Oral Exposure""; ""Absorption""; ""Other Factors Affecting Oral Absorption""
  • ""Distribution and Uptake of Chemicals""""Retention""; ""Metabolism of Xenobiotic Compounds""; ""Excretion""; ""SCALING AND REGRESSION ANALYSIS""; ""Body Weight""; ""Other Effects of Body Size""; ""Surface Area""; ""Metabolic Rate""; ""Regression Analysis""; ""CONCLUSIONS AND RECOMMENDATIONS""; ""Conclusions""; ""Recommendations""; ""REFERENCES""; ""4 Methods for Toxicity Testing ""; ""CURRENT METHODS: GENERAL CONSIDERATIONS""; ""ACUTE TOXICITY STUDIES""; ""General Description""; ""EPA's Proposed Changes""; ""SUBCHRONIC TOXICITY STUDIES""; ""General Description""; ""EPA's Proposed Changes""
  • ""CHRONIC TOXICITY STUDIES""""General Description""; ""EPA's Proposed Changes""; ""DEVELOPMENTAL TOXICITY STUDIES""; ""General Description""; ""EPA's Proposed Changes""; ""REPRODUCTION STUDIES""; ""General Description""; ""EPA's Proposed Changes""; ""MUTAGENICITY STUDIES""; ""General Description""; ""EPA's Proposed Changes""; ""GENERAL METABOLISM STUDIES""; ""General Description""; ""EPA's Proposed Changes""; ""NEUROTOXICITY STUDIES""; ""General Description""; ""EPA's Proposed Changes""; ""SPECIAL TESTING""; ""CONCLUSIONS AND RECOMMENDATIONS""; ""Conclusions""; ""Recommendations""