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Issues in Risk Assessment.
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Washington :
National Academies Press,
1900.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- ""ISSUES IN RISK ASSESSMENT""; ""Copyright""; ""Preface""; ""Contents""; ""Executive Summary""; ""USE OF THE MAXIMUM TOLERATED DOSE IN ANIMAL BIOASSAYS FOR CARCINOGENICITY""; ""THE TWO-STAGE MODEL OF CARCINOGENESIS""; ""A PARADIGM FOR ECOLOGIC RISK ASSESSMENT""; ""Issues In Risk Assessment Use Of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity""; ""1 Introduction ""; ""BACKGROUND""; ""SCOPE OF REPORT""; ""2 Correlations Between Carcinogenic Potency and Other Measures of Toxicity ""; ""DEFINITIONS AND BACKGROUND""; ""CORRELATIONS""
- ""RELATIONSHIP BETWEEN TOXICITY AND CARCINOGENICITY OBSERVED AT MTD""""3 Advantages and Disadvantages of Bioassays that Use the MTD ""; ""QUALITATIVE INFORMATION""; ""QUANTITATIVE INFORMATION""; ""4 Options Considered ""; ""OPTION 1""; ""OPTION 2""; ""OPTION 3""; ""OPTION 4""; ""Option 4A""; ""Option 4B""; ""5 Conclusions and Recommendations ""; ""REFERENCES""; ""Appendix A Workshop Summary Maximum Tolerated Dose: Implications For Risk Assessment ""; ""INTRODUTION""; ""BACKGROUND""; ""DEFINING AND DETERMINING THE MTD""; ""Appendix B Organizing Subcommittee ""
- ""Appendix C Federal Liaison Group """"Appendix D Workshop Program ""; ""Appendix E Workshop Attendees ""; ""Appendix F Correlation Between Carcinogenic Potency and the Maximum Tolerated Dose: Implications for Risk Assessment""; ""1. INTRODUCTION""; ""2. CARCINOGENIC POTENCY""; ""2.1 Measures of Carcinogenic Potency""; ""2.2 Carcinogenic Potency Database (CPDB)""; ""2.3 Variation in Carcinogen Potency""; ""2.4 Classification of Carcinogens""; ""3. CORRELATION BETWEEN TD50 AND THE MTD""; ""3.1 Empirical Correlations""; ""3.2 Range of Possible TD50 Values""; ""3.3 Analytical Correlations""
- ""3.4 Model Dependency""""3.5 Genotoxic vs. Nongenotoxic Carcinogens""; ""4. PREDICTION OF THE TD50""; ""4.1 Predictions Based on the MDT""; ""4.2 Predictions Based on Mutagenicity and Acute Toxicity""; ""5. LOW DOSE RISK ASSESSMENT""; ""5.1 Correlation Between Upper Bounds On the Low Dose Slope and MTD""; ""5.2 Correlation Between q1* and the TD50""; ""5.3. Preliminary Estimate of Risk""; ""6. INTERSPECIES EXTRAPOLATION""; ""6.1 Extrapolation from Rats to Mice""; ""6.2 Extrapolation from Rodents to Humans""; ""7. CONCLUSIONS""; ""8. ACKNOWLEDGEMENTS""; ""9. REFERENCES""
- ""ANNEX A: MAXIMUM LIKELIHOOD METHODS FOR FITTING THE WEIBULL MODEL""""ANNEX B. SHRINKAGE ESTIMATORS OF THE DISTRIBUTION OF CARCINOGENIC POTENCY""; ""ANNEX C: ADJUSTMENT OF POTENCY VALUES FOR LESS THAN LIFETIME EXPOSURE""; ""ANNEX D: CORRELATION BETWEEN TD50 AND MTD""; ""ANNEX E: CORRELATION BETWEEN TD50S FOR RATS AND MICE""; ""Appendix G Informal Search for ''Supercarcinogens"" ""; ""CRITERIA AND CANDIDATE CHEMICALS""; ""DATA""; ""RESULTS""; ""DISCUSSION""; ""Issues in Risk Assessment The Two-Stage Model Of Carcinogenesis ""; ""The Two-Stage Model of Carcinogenesis""; ""INTRODUCTION""