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049 |a UAMI 
100 1 |a Lattman, Eaton E. 
245 1 0 |a Protein Crystallography :  |b a Concise Guide. 
260 |a Baltimore :  |b Johns Hopkins University Press,  |c 2008. 
300 |a 1 online resource (152 pages) 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
588 0 |a Print version record. 
505 0 |a Contents -- Preface -- Chapter 1. Introduction -- 1.1 What Is X-ray Crystallography? -- 1.2 A Quick Look at Protein Crystals -- 1.3 Noncrystalline Specimens -- 1.4 Summary -- Further Reading -- Chapter 2. A Physical Understanding of Diffraction -- 2.1 What Is Diffraction? -- 2.2 Diffraction from One-Dimensional Crystals -- 2.3 Reconstructing Images from Diffraction Patterns -- 2.4 Summary -- Further Reading -- Chapter 3. Diffraction from Three-Dimensional Crystals -- 3.1 The Electron Density Function in Three Dimensions 
505 8 |a 3.2 Calculating the Diffraction Pattern from a Known Structure3.3 Summary -- Further Reading -- Chapter 4. Phase Determination by Isomorphous Replacement -- 4.1 Measuring the Phases -- 4.2 MAD Phasing -- 4.3 Fitting Models to Experimental Electron Density Maps -- 4.4 Summary -- Further Reading -- Chapter 5. The Patterson Function -- 5.1 Definition of the Patterson Function -- 5.2 Using the Patterson Function to Locate Atoms -- 5.3 Summary -- Further Reading -- Chapter 6. Phasing with Partially Known Structures -- 6.1 Difference Fourier Maps 
505 8 |a 6.2 Molecular Replacement6.3 Summary -- Further Reading -- Chapter 7. Crystallographic Refinement -- 7.1 Refinement Improves the Model -- 7.2 Least-Squares Refinement -- 7.3 Summary -- Further Reading -- Glossary -- A -- B -- C -- D -- E -- F -- H -- I -- L -- M -- N -- O -- P -- R -- S -- T -- U -- V -- W -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- X -- Z 
504 |a Includes bibliographical references and index. 
520 8 |a Annotation  |b The proteome remains a mysterious realm. Researchers have determined the structures of only a small fraction of the proteins encoded by the human genome. Crystallography continues to be the primary method used to determine the structures of the remaining unknown proteins. This imaging technique uses the diffraction of X-rays to determine a protein's three-dimensional molecular structure. Drawing on years of research and teaching experience, Eaton E. Lattman and Patrick J. Loll use clear examples and abundant illustrations to provide a concise and accessible primer on protein crystallography. Discussing the basics of diffraction, the behavior of two- and three-dimensional crystals, phase determination (including MIR and MAD phasing and molecular replacement), the Patterson function, and refinement, Lattman and Loll provide a complete overview of this important technique, illuminated by physical insights. The crisp writing style and simple illustrations will provide beginner crystallographers with a guide to the process of unraveling protein structure. 
590 |a ProQuest Ebook Central  |b Ebook Central Academic Complete 
650 0 |a Proteins  |x Structure. 
650 0 |a X-ray crystallography. 
650 0 |a Proteins  |x Conformation. 
650 2 |a Proteins  |x chemistry 
650 2 |a Crystallography, X-Ray  |x methods 
650 2 |a Protein Conformation 
650 2 |a Proteomics  |x methods 
650 2 |a Crystallography, X-Ray 
650 6 |a Protéines  |x Structure. 
650 6 |a Radiocristallographie. 
650 6 |a Protéines  |x Conformation. 
650 7 |a MEDICAL  |x Biochemistry.  |2 bisacsh 
650 7 |a Proteins  |x Conformation  |2 fast 
650 7 |a Proteins  |x Structure  |2 fast 
650 7 |a X-ray crystallography  |2 fast 
650 1 7 |a Eiwitten.  |2 gtt 
650 1 7 |a Kristallografie.  |2 gtt 
650 7 |a Proteínas (estrutura)  |2 larpcal 
650 7 |a Cristalografia de raios x.  |2 larpcal 
700 1 |a Loll, Patrick J. 
758 |i has work:  |a Protein crystallography (Text)  |1 https://id.oclc.org/worldcat/entity/E39PCGp8kD6j9CKBkg7mdxBfmd  |4 https://id.oclc.org/worldcat/ontology/hasWork 
776 0 8 |i Print version:  |a Lattman, Eaton E.  |t Protein Crystallography : A Concise Guide.  |d Baltimore : Johns Hopkins University Press, ©1900  |z 9780801888069 
856 4 0 |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=3318495  |z Texto completo 
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