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Cancer Cytogenetics : Chromosomal and Molecular Genetic Aberrations of Tumor Cells.
The first three editions of this acclaimed book presented a much-needed conceptual synthesis of this rapidly moving field. Now, Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up-to-date review of recent dramatic advances in this area, incorporating a vast amount of new da...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken :
Wiley,
2015.
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| Edición: | 4th ed. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Title Page; Copyright Page; Contents; Contributors; Preface to the Fourth Edition; Chapter 1 How it all began: cancer cytogenetics before sequencing; References; Chapter 2 Cytogenetic methods; Sampling for cytogenetic analysis; Chromosome banding; In situ hybridization; Genomic arrays; Large-scale sequencing; Interpretation of cytogenetic data; References; Chapter 3 Cytogenetic nomenclature; Designation of regions and bands; Karyotypic nomenclature; Nomenclature of tumor cell populations; In situ hybridization nomenclature; References.
- Chapter 4 Nonrandom chromosome abnormalities in cancer: an overviewPrimary and secondary neoplasia-associated chromosome abnormalities; Why and how do chromosome aberrations arise?; When do chromosome aberrations arise?; In which cells do chromosome aberrations arise?; Are acquired chromosome aberrations sufficient for neoplastic proliferation?; Do all tumors have chromosome abnormalities, and are such changes present only in neoplastic cells?; General effects of structural and numerical chromosome abnormalities; Net loss of chromosomal material; Net gain of chromosomal material.
- Relocation of sequences with no gain or loss of genetic materialAt what resolution level are neoplasia-associated mutations best studied?; Pathogenetic versus phenotypic tumor classification; References; Chapter 5 From chromosomes to genes: searching for pathogenetic fusions in cancer; Types of fusion genes; Fusion genes involving regulatory elements of the immunoglobulin and T-cell receptor genes; Promoter swapping; Fusion genes coding for fusion proteins; "Out-of-frame" fusion transcripts; Generation of fusion genes; Methods to identify fusion genes; Methodologies based on cytogenetics.
- "Omics" and gene expression-based methodologiesComparative genomic hybridization-based methodology; Protein-based methodologies; DNA-mediated transformation methodology; Clinic-based methodology; Next-generation sequencing-based methodologies; Conclusion; References; Chapter 6 Acute myeloid leukemia; Most AML harbor clonal chromosomal abnormalities; Impact of age; Impact of previous treatment/genotoxic exposure; Impact of gender; Impact of geographic/ethnic origin; Impact of constitutional genetics; Characteristic chromosomal abnormalities in AML; t(1; 3)(p36; q21) [RPN1-PRDM16]; t(1; 21)(p36.
- Q22) [RUNX1-PRDM16]t(1; 16)(p31; q24) [NFIA-CBFA2T3]; t(1; 11)(p32; q23) [MLL-EPS15]; t(1; 22)(p13; q13) [RBM15-MKL1]; der(1; 7)(q10; p10); t(1; 11)(q21; q23) [MLL-MLLT11]; t(2; 3)(p11)~)23; q23)~)28) [MECOM deregulation]; t(2; 11)(p21; q23) [MLL rearrangement]; t(2; 11)(q31; p15) [NUP98-HOXD11(13)]; t(2; 11)(q37; q23) [MLL-SEPT2]; inv(3)(q21q26)/t(3; 3)(q21; q26) [RPN1-MECOM]; t(3; 5)(q25; q35) [NPM1-MLF1]; t(3; 12)(q26; p13) [ETV6-MECOM]; t(3; 21)(q26; q22) [RUNX1-MECOM]; Trisomy 4; t(4; 12)(q12; p13) [CHIC2-ETV6]; t(4; 11)(q21; q23) [MLL-AFF1]; Monosomy 5/del(5q); t(5; 11)(q31.