Basic principles of drug discovery and development /

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Benjamin, Blass (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam [Netherlands] : Academic Press, 2015.
Temas:
Drug development.
Drugs > Design.
Drug Design
Médicaments > Développement.
Médicaments > Conception.
Drug development
Drugs > Design
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover; Basic Principles of Drug Discovery and Development; Copyright; Dedication; Contents; Foreword; Chapter 1
  • Drug Discovery and Development: An Overview of Modern Methods and Principles; DRUG DISCOVERY AND DEVELOPMENT FROM 20,000FEET (FIGURE 1.7); TARGET SELECTION: THE FIRST STEP FORWARD; HIT IDENTIFICATION: FINDING A STARTING POINT; IDENTIFY A CLINICAL CANDIDATE: JUGGLING THE PROPERTIES; QUESTIONS; References; Chapter 2
  • The Drug Discovery Process: From Ancient Times to the Present Day; THE AGE OF BOTANICALS: PREINDUSTRIAL DRUG DISCOVERY.
  • PAUL EHRLICH: THE FATHER OF MODERN DRUG DISCOVERY10MILESTONES IN DRUG DISCOVERY; THE RISE OF BIOLOGICS AND MACROMOLECULAR THERAPEUTICS; SOCIETAL AND GOVERNMENTAL IMPACTS; REGULATORY MILESTONES; FUTURE DEVELOPMENTS IN DRUG DISCOVERY; QUESTIONS; References; Chapter 3
  • Classical Targets in Drug Discovery; PROTEIN STRUCTURE; ENZYMES; INHIBITION OF ENZYMES; G-PROTEIN-COUPLED RECEPTORS (GPCRS); ION CHANNELS; MEMBRANE TRANSPORT PROTEINS (TRANSPORTERS); EMERGING TARGETS; QUESTIONS; References; Chapter 4
  • In vitro Screening Systems; THE LANGUAGE OF SCREENING: BASIC TERMS; STREPTAVIDIN AND BIOTIN.
  • BIOCHEMICAL VERSUS CELLULAR ASSAYSASSAY SYSTEMS AND METHODS OF DETECTION; RADIOLIGAND ASSAY SYSTEMS; ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA); FLUORESCENCE-BASED ASSAY SYSTEMS; REPORTER GENE ASSAYS; KINETIC FLUORESCENT MEASUREMENT SYSTEMS; LABEL-FREE ASSAY SYSTEMS; ELECTROPHYSIOLOGICAL PATCH CLAMP; GENERAL CONSIDERATION FOR ALL SCREENING METHODS; QUESTIONS; References; Chapter 5
  • Medicinal Chemistry; STRUCTURE-ACTIVITY RELATIONSHIPS AND STRUCTURE-PROPERTY RELATIONSHIPS; THE ROLE OF CHIRALITY; PUSH AND PULL IN STRUCTURE-ACTIVITY RELATIONSHIPS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS.
  • THE PHARMACOPHOREDEVELOPING AN SAR DATA SET; THE STRUCTURE-ACTIVITY RELATIONSHIP CYCLE; BIOISOSTERISM; STRUCTURE-ACTIVITY RELATIONSHIP, SELECTIVITY AND PHYSICOCHEMICAL PROPERTIES; "DRUGLIKE" GUIDELINES; QUESTIONS; References; Chapter 6
  • In vitro ADME and In vivo Pharmacokinetics; ABSORPTION; DISTRIBUTION; ELIMINATION PATHWAYS; IN VITRO ADME SCREENING METHODS; IN VIVO PHARMACOKINETICS; SPECIES SELECTION; QUESTIONS; References; Chapter 7
  • Animal Models of Disease States; SOURCES OF ANIMAL MODELS; VALIDITY OF ANIMAL MODELS; SPECIES SELECTION; NUMBER OF ANIMALS.
  • EXEMPLARY ANIMAL MODELS BY DISEASE CATEGORYANIMAL MODELS OF INFECTIOUS DISEASE; ANIMAL MODELS OF ONCOLOGY; QUESTIONS; References; Chapter 8
  • Safety and Toxicology; SOURCES OF TOXICITY; ACUTE VERSUS CHRONIC TOXICITY; CYTOTOXICITY; CARCINOGENICITY, GENOTOXICITY, AND MUTAGENICITY; DRUG-DRUG INTERACTIONS; CARDIOVASCULAR SAFETY AND TOXICOLOGY STUDIES; CENTRAL NERVOUS SYSTEM SAFETY AND TOXICOLOGY STUDIES; IMMUNE SYSTEM MEDIATED SAFETY ISSUES; TERATOGENICITY; IN VIVO TOXICITY AND SAFETY STUDIES; QUESTIONS; References; Chapter 9
  • Basics of Clinical Trials; BEFORE THE CLINIC; DRUG SUPPLY.

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