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Controlled drug delivery : the role of self-assembling multi-task excipients /
In complex macromolecules, minor modifications can generate major changes, due to self-assembling capacities of macromolecular or supramolecular networks. Controlled Drug Delivery highlights how the multifunctionality of several materials can be achieved and valorized for pharmaceutical and biopharm...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, UK ; Waltham, MA, USA :
Elsevier Woodhead Publishing,
[2015]
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| Colección: | Woodhead Publishing series in biomedicine ;
no. 58. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Controlled Drug Delivery; Copyright Page; Contents; List of figures; List of tables; Biography for book; 1 The concept of self-assembling and the interactions involved; 1.1 The concept of self-assembling; 1.1.1 The concept of self-assembling by association/interaction processes; 1.2 The nature of forces and types of interactions involved in self-assembly of macromolecules; 1.3 Hydrogels and their role in drug conception and development; 1.3.1 Organogels and micelles for drug delivery; 1.4 Self-assembling phenomena in solid dosage forms.
- 1.4.1 Hydrogen association and flexibility of chains1.4.2 Ionically stabilized excipients; 1.4.2.1 Two-speed self-assembled monolithic devices; 1.4.3 Hydrophobic stabilization of excipients and drug release mechanisms; 1.4.3.1 The concept of self-assembling by inclusion processes; 1.4.3.2 Inclusion complexes of starch with fatty bioactive agents; 1.4.3.3 Inclusion complexes and hydrophobic assembly of starch excipients; 1.5 Conclusions; References; 2 Starch and derivatives as pharmaceutical excipients; 2.1 General aspects; 2.2 Structural considerations.
- 2.3 Self-assembling in physically modified starches2.3.1 Pregelatinized starch; 2.3.2 Multifunctional excipient: binder-filler and binder-disintegrant; 2.3.3 Extruded starch; 2.3.4 Soft starch capsules; 2.3.5 Hard capsules; 2.3.6 Starch films as functional coatings; 2.3.7 Starch microspheres and nanospheres in drug delivery; 2.3.8 Starch complexes; 2.3.9 Conclusions; 2.4 Chemically modified starches and their self-assembling; 2.4.1 Self-assembling in cross-linked starches; 2.4.2 Starch ethers; 2.4.3 Ionic starches and their self-assembling features; 2.4.3.1 CMS as pH-responsive excipient.
- 3.3.6 Phthaloylchitosan and other hydrophobically modified chitosans3.3.7 Hydrophobic drug-grafted chitosan; 3.4 Amphiphilic/amphoteric chitosan derivatives; 3.4.1 Hydrophobically modified carboxylated chitosan; 3.4.1.1 Alkyl-modified carboxylated chitosan; 3.4.1.2 Acyl-modified carboxylated chitosan; 3.4.1.3 Cholesterol-modified carboxylated chitosan; 3.4.1.4 Deoxycholic acid-modified carboxylated chitosan; 3.4.2 Hydrophobically modified sulfated chitosan; 3.5 Conclusion; References; 4 Chitosan-based polyelectrolyte complexes as pharmaceutical excipients; Abbreviations.