Cargando…
Antitargets and drug safety /
With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided into three major parts, the first section deals with novel technologies and includes the utility of a...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Weinheim :
Wiley-VCH,
2015.
|
| Colección: | Methods and principles in medicinal chemistry ;
v. 66. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
| LEADER | 00000cam a2200000 a 4500 | ||
|---|---|---|---|
| 001 | EBOOKCENTRAL_ocn904518353 | ||
| 003 | OCoLC | ||
| 005 | 20240329122006.0 | ||
| 006 | m o d | ||
| 007 | cr cnu---unuuu | ||
| 008 | 150307s2015 gw ob 001 0 eng d | ||
| 040 | |a EBLCP |b eng |e pn |c EBLCP |d OCLCO |d RECBK |d N$T |d YDXCP |d IDEBK |d CDX |d DG1 |d E7B |d OCLCF |d COO |d DEBBG |d OCLCQ |d OHI |d K6U |d LVT |d DG1 |d LIP |d VGM |d OCLCO |d ZCU |d NRC |d OCLCO |d OCLCQ |d MERUC |d OCLCO |d OCLCQ |d OCLCO |d OCLCA |d SGB |d OCLCQ |d ICG |d AU@ |d OCLCQ |d U3W |d OCLCQ |d DKC |d OCLCO |d OCLCQ |d UKAHL |d OCLCQ |d OCLCA |d OCLCO |d LUU |d OCLCQ |d OCLCO |d OCLCL | ||
| 019 | |a 909907512 |a 953987850 |a 960203676 |a 961625844 |a 962626284 |a 969506589 |a 972071490 |a 989317120 | ||
| 020 | |a 9783527673643 |q (electronic bk.) | ||
| 020 | |a 3527673644 |q (electronic bk.) | ||
| 020 | |a 9783527673674 |q (electronic bk.) | ||
| 020 | |a 3527673679 |q (electronic bk.) | ||
| 020 | |z 9783527673667 | ||
| 020 | |z 3527673660 | ||
| 020 | |z 9783527335114 | ||
| 020 | |z 3527335110 | ||
| 029 | 1 | |a AU@ |b 000060585305 | |
| 029 | 1 | |a CHDSB |b 006359936 | |
| 029 | 1 | |a CHNEW |b 000944082 | |
| 029 | 1 | |a CHVBK |b 480243123 | |
| 029 | 1 | |a DEBBG |b BV042792550 | |
| 029 | 1 | |a DEBBG |b BV043397595 | |
| 029 | 1 | |a DEBBG |b BV044073599 | |
| 029 | 1 | |a DEBSZ |b 485056453 | |
| 035 | |a (OCoLC)904518353 |z (OCoLC)909907512 |z (OCoLC)953987850 |z (OCoLC)960203676 |z (OCoLC)961625844 |z (OCoLC)962626284 |z (OCoLC)969506589 |z (OCoLC)972071490 |z (OCoLC)989317120 | ||
| 050 | 4 | |a RS420 | |
| 060 | 4 | |a QV 745 | |
| 072 | 7 | |a MED |x 071000 |2 bisacsh | |
| 082 | 0 | 4 | |a 615.19 |2 23 |
| 049 | |a UAMI | ||
| 245 | 0 | 0 | |a Antitargets and drug safety / |c edited by Laszlo Urban, Vinod F. Patel and Roy J. Vaz. |
| 260 | |a Weinheim : |b Wiley-VCH, |c 2015. | ||
| 300 | |a 1 online resource (1266 pages) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Methods and principles in medicinal chemistry ; |v v. 66 | |
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |a General Concept for Target-based Safety Assessment. Side Effects of Marketed Drugs: The Utility and Pitfalls of Pharmacovigilance / Steven Whitebread, Mateusz Maciejewski, Alexander Fekete, Eugen Lounkine, László Urbán -- Prediction of Drug Side Effects / Michael J Keiser -- Translational Value of Preclinical Safety Assessment: System Organ Class (SOC) Representation of Off-Targets / Mateusz Maciejewski, Eugen Lounkine, Andreas Hartmann, Steven Whitebread, László Urbán -- Pathological Conditions Associated with the Disturbance of the 5-HT System / Daniel Hoyer -- Hepatic Side Effects. Drug-Induced Liver Injury: Clinical and Diagnostic Aspects / John R Senior -- Mechanistic Safety Biomarkers for Drug-Induced Liver Injury / Daniel J Antoine -- Models for the Prediction of Drug-Induced Liver Injury in Lead Discovery / Frederic Moulin, Oliver Flint -- Transporters in the Liver / Bruno Stieger, Gerd A Kullak-Ublick -- Mechanistic Modeling of Drug-Induced Liver Injury (DILI) / Kyunghee Yang, Jeffrey L Woodhead, Lisl K Shoda, Yuching Yang, Paul B Watkins, Kim LR Brouwer, Brett A Howell, Scott Q Siler -- Cardiovascular Side Effects. Functional Cardiac Safety Evaluation of Novel Therapeutics / Jean-Pierre Valentin, Brian Guth, Robert L Hamlin, Pierre Lainée, Dusty Sarazan, Matt Skinner -- Safety Aspects of the Ca1.2 Channel / Berengere Dumotier, Martin Traebert -- Cardiac Sodium Current (Na1.5) / Gary Gintant -- Circulating Biomarkers for Drug-Induced Cardiotoxicity: Reverse Translation from Patients to Nonclinical Species / Gül Erdemli, Haisong Ju, Sarita Pereira -- The Mechanistic Basis of hERG Blockade and the Proarrhythmic Effects Thereof / Robert A Pearlstein, K Andrew MacCannell, Qi-Ying Hu, Ramy Farid, José S Duca -- Kinase Antitargets. Introduction to Kinase Antitargets / Mark C Munson -- Clinical and Nonclinical Adverse Effects of Kinase Inhibitors / Douglas A Keller, Richard J Brennan, Karen L Leach -- Cardiac Side Effects Associated with Kinase Proteins and Their Signaling Pathways / Roy J Vaz, Vinod F Patel -- Case Studies: Selective Inhibitors of Protein Kinases : Exploiting Demure Features / Ellen R Laird -- Examples of Clinical Translation. Torcetrapib and Dalcetrapib Safety: Relevance of Preclinical and Models / Eric J Niesor, Andrea Greiter-Wilke, Lutz Müller -- Targets Associated with Drug-Related Suicidal Ideation and Behavior / Andreas Hartmann, Steven Whitebread, Jacques Hamon, Alexander Fekete, Christian Trendelenburg, Patrick Y Müller, László Urbán. | |
| 520 | |a With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings, broader computational prediction of drug side-effects, and a description of the serotonergic system. The main part of the book looks at some of the most common antitarget-mediated side effects, focusing on hepatotoxicity in drug safety, cardiovascular toxicity and signaling effects via kinase and GPCR anti-targets. In the final section, several case studies of recently developed drugs illustrate how to prevent anti-target effects and how big pharma deals with them if they occur. The more recent field of systems pharmacology has gained prominence and this is reflected in chapters dedicated to the utility in deciphering and modeling anti-targets. The final chapter is concerned with those compounds that inadvertently elicit CNS mediated adverse events, including a pragmatic description of ways to mitigate these types of safety risks. Written as a companion to the successful book on antitargets by Vaz and Klabunde, this new volume focuses on recent progress and new classes, methods and case studies that were not previously covered. - Publisher. | ||
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Drug development. | |
| 650 | 0 | |a Drugs |x Design. | |
| 650 | 0 | |a Drugs |x Side effects. | |
| 650 | 0 | |a Drug interactions. | |
| 650 | 2 | |a Drug Design | |
| 650 | 2 | |a Drug-Related Side Effects and Adverse Reactions | |
| 650 | 6 | |a Médicaments |x Développement. | |
| 650 | 6 | |a Médicaments |x Conception. | |
| 650 | 6 | |a Médicaments |x Effets secondaires. | |
| 650 | 6 | |a Interactions médicamenteuses. | |
| 650 | 7 | |a MEDICAL |x Pharmacology. |2 bisacsh | |
| 650 | 7 | |a Drug development |2 fast | |
| 650 | 7 | |a Drug interactions |2 fast | |
| 650 | 7 | |a Drugs |x Design |2 fast | |
| 650 | 7 | |a Drugs |x Side effects |2 fast | |
| 700 | 1 | |a Urbán, László. | |
| 700 | 1 | |a Patel, Vinod F. | |
| 700 | 1 | |a Vaz, Roy J. | |
| 758 | |i has work: |a Antitargets and drug safety (Text) |1 https://id.oclc.org/worldcat/entity/E39PCFQqQfqbG9jTD6wkqVqRKd |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
| 776 | 0 | 8 | |i Print version: |a Urban, Laszlo. |t Antitargets and Drug Safety. |d Hoboken : Wiley, ©2015 |z 9783527335114 |
| 830 | 0 | |a Methods and principles in medicinal chemistry ; |v v. 66. | |
| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=1977788 |z Texto completo |
| 938 | |a Askews and Holts Library Services |b ASKH |n AH28310002 | ||
| 938 | |a Askews and Holts Library Services |b ASKH |n AH28309997 | ||
| 938 | |a Coutts Information Services |b COUT |n 31158518 | ||
| 938 | |a EBL - Ebook Library |b EBLB |n EBL1977788 | ||
| 938 | |a ebrary |b EBRY |n ebr11048186 | ||
| 938 | |a EBSCOhost |b EBSC |n 981374 | ||
| 938 | |a ProQuest MyiLibrary Digital eBook Collection |b IDEB |n cis31158518 | ||
| 938 | |a Recorded Books, LLC |b RECE |n rbeEB00597802 | ||
| 938 | |a YBP Library Services |b YANK |n 12326969 | ||
| 938 | |a YBP Library Services |b YANK |n 12409935 | ||
| 938 | |a YBP Library Services |b YANK |n 11419842 | ||
| 994 | |a 92 |b IZTAP | ||