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ABC Transporters and Cancer /
ABC Transporters and Cancer provides invaluable information on the exciting and fast-moving field of cancer research. Here, outstanding and original reviews are presented on a variety of topics. This volume covers ABC transporters and cancer, and is suitable for researchers and students alike.
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Elsevier Ltd.,
2015.
|
| Edición: | First edition. |
| Colección: | Advances in cancer research ;
v. 125. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a ABC Transporters and Cancer / |c edited by John D. Schuetz, Toshihisa Ishikawa. |
| 250 | |a First edition. | ||
| 264 | 1 | |a Amsterdam : |b Elsevier Ltd., |c 2015. | |
| 300 | |a 1 online resource (280 pages, 10 unnumbered pages of plates) : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a text file | ||
| 490 | 1 | |a Advances in cancer research ; |v v. 125 | |
| 546 | |a Text in English. | ||
| 504 | |a Includes bibliographical references at the end of each chapters and index. | ||
| 520 | |a ABC Transporters and Cancer provides invaluable information on the exciting and fast-moving field of cancer research. Here, outstanding and original reviews are presented on a variety of topics. This volume covers ABC transporters and cancer, and is suitable for researchers and students alike. | ||
| 505 | 0 | |a Front Cover; ABC Transporters and Cancer; Copyright; Dedication; Contents; Contributors; Preface; Chapter 1: Apical ABC Transporters and Cancer Chemotherapeutic Drug Disposition; 1. Introduction to Apical ABC Transporters; 2. Impact of Apical ABC Transporters on Intestinal Absorption of Oral Chemotherapeutic Drugs; 2.1. Apical ABC transporters affecting the oral bioavailability of taxanes; 2.1.1. ABCB1 and oral taxane availability; 2.1.2. ABCC2 and oral taxane availability; 2.1.3. ABCB1 inhibitors to improve taxane oral availability. | |
| 505 | 8 | |a 2.1.4. Assessing CNS toxicity risks of using ABCB1 inhibitors to improve oral taxane availability2.1.5. Possible effects of ABCB1 inhibitors on enhancing taxane antitumor efficacy; 2.2. Apical ABC transporters in the oral bioavailability of rationally designed anticancer drugs; 2.2.1. Tyrosine kinase inhibitors; 2.2.2. PARP inhibitors; 2.2.3. Chemical inhibition of transporters to increase oral availability of rationally designed anticancer drugs; 2.2.4. Importance of the sensitivity and specificity of in vitro assays used to assess ABC transporter substrates. | |
| 505 | 8 | |a 3. Impact of Apical ABC Transporters on Brain Disposition of Oral Chemotherapeutic Drugs3.1. Does the BBB matter in drug delivery to brain tumors?; 3.2. Apical efflux transporters in the BBB affecting brain accumulation of anticancer drugs; 3.2.1. Drugs affected mostly by Abcb1a but also by Abcg2 in their brain accumulation; 3.2.2. Drugs only affected by Abcb1a in their brain accumulation; 3.2.3. Drugs affected mostly by Abcg2 but also by Abcb1a in their brain accumulation; 3.2.4. Three different apical BBB ABC efflux transporters affect brain accumulation of some camptothecins. | |
| 505 | 8 | |a 3.2.5. Models to explain the disproportionate effect of combined deficiency of Abcb1 and Abcg2 on brain accumulation of s ... 3.2.6. Why are many rationally designed anticancer drugs still ABCB1 and/or ABCG2 substrates?; 3.2.7. Limitations of knockout mouse models to study ABC transporter functions at the BBB; 3.2.8. Tissue and cellular context may affect the in vivo impact of apical ABC efflux transporters; 3.2.9. Use of chemical inhibitors to enhance brain accumulation of ABC transporter substrate drugs; 4. Concluding Remarks; References. | |
| 505 | 8 | |a Chapter 2: Regulation of ABC Transporters Blood-Brain Barrier: The Good, the Bad, and the Ugly1. Introduction; 2. Blood-Brain Barriers; 2.1. Assessing blood-brain barrier function; 3. ABC Transporters at the Blood-Brain Barrier; 4. The Bad and the Ugly: Mechanisms that Increase Transporter Expression and Reduce Drug Delivery to the CNS; 4.1. Xenobiotic-activated transcription factors; 4.2. Stress-activated transcription factors; 4.3. Disease; 5. The Good: Mechanisms that Reduce Transporter Activity/Expression and Have the Potential to Improve Drug Delivery to th ... ; 5.1. P-glycoprotein. | |
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Cancer |x Research. | |
| 650 | 0 | |a Drug resistance in cancer cells. | |
| 650 | 0 | |a Cancer |x Chemotherapy. | |
| 650 | 0 | |a ATP-binding cassette transporters. | |
| 650 | 1 | 2 | |a Drug Resistance, Neoplasm |
| 650 | 2 | 2 | |a ATP-Binding Cassette Transporters |
| 650 | 2 | 2 | |a Antineoplastic Agents |x pharmacokinetics |
| 650 | 6 | |a Cancer |x Recherche. | |
| 650 | 6 | |a Cellules cancéreuses |x Résistance aux médicaments. | |
| 650 | 6 | |a Cancer |x Chimiothérapie. | |
| 650 | 6 | |a Transporteurs ABC. | |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x General. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Clinical Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Diseases. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Evidence-Based Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Internal Medicine. |2 bisacsh | |
| 650 | 7 | |a ATP-binding cassette transporters |2 fast | |
| 650 | 7 | |a Cancer |x Chemotherapy |2 fast | |
| 650 | 7 | |a Cancer |x Research |2 fast | |
| 650 | 7 | |a Drug resistance in cancer cells |2 fast | |
| 655 | 4 | |a Internet Resources. | |
| 655 | 4 | |a Index not Present. | |
| 700 | 1 | |a Schuetz, John D., |e editor. | |
| 700 | 1 | |a Ishikawa, Toshihisa, |e editor. | |
| 776 | 0 | 8 | |i Print version: |a Ishikawa, Toshihisa. |t ABC Transporters and Cancer. |d Burlington : Elsevier Science, ©2015 |z 9780128012512 |
| 830 | 0 | |a Advances in cancer research ; |v v. 125. | |
| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=1934473 |z Texto completo |
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