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Bioorganometallic Chemistry.
An up-to-date reference reflecting the significant advances and important breakthroughs made in this emerging discipline over the last decade. As such, the book provides an overview of the latest developments and future trends in the field, focusing on such applications as the development of potenti...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
[Place of publication not identified] :
John Wiley and Sons, Inc.,
2014.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Bioorganometallic Chemistry: Applications in Drug Discovery, Biocatalysis, and Imaging; Contents; List of Contributors; Preface; Part One: Medicinal Chemistry; 1. Organometallic Complexes as Enzyme Inhibitors: A Conceptual Overview; 1.1 Introduction; 1.2 Organometallic Compounds as Inert Structural Scaffolds for Enzyme Inhibition; 1.3 Organometallic Compounds Targeting Specific Protein Residues; 1.4 The Bioisosteric Substitution; 1.5 Novel Mechanisms of Enzyme Inhibition with Organometallic Compounds; 1.6 Organometallic Compounds as Cargo Delivers of Enzyme Inhibitors.
- 1.7 Organometallic Enzyme Inhibitors for Theranostic Purposes1.8 Conclusion; Acknowledgments; Abbreviations; References; 2. The Biological Target Potential of Organometallic Steroids; 2.1 Introductory Note on Nuclear Receptors; 2.1.1 Early History; 2.1.2 Primary Structure of Nuclear Receptors; 2.1.3 Estrogen Receptors; 2.1.4 Androgens; 2.1.5 Glucocorticoids; 2.1.6 Progesterone and Progestogens; 2.1.7 Mineralocorticoids and Aldosterone; 2.1.8 Selective Modulators of Nuclear Receptors; 2.1.8.1 Selective Estrogen Receptor Modulators (SERMs); 2.1.8.2 Selective Androgen Receptor Modulators (SARMs).
- 2.2.4 Approach Toward Organometallic Radiopharmaceuticals2.2.4.1 Steroidal Derivatives; 2.2.4.2 Nonsteroidal Complexes; 2.3 Epilog; Acknowledgments; References; 3. Chirality in Organometallic Anticancer Complexes; 3.1 Introduction; 3.2 Chirality in Arene Complexes; 3.3 CIP System for the Nomenclature of Chiral-at-Metal Arene Complexes; 3.4 Chiral Organometallic Complexes as Anticancer Agents; 3.4.1 Chiral Carbene Complexes; 3.4.2 Chiral Metallocene Complexes; 3.4.3 Chiral Half-Sandwich Arene Complexes; 3.4.4 Chirality at Metal in Supramolecular Complexes.