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Bioorganometallic Chemistry.
An up-to-date reference reflecting the significant advances and important breakthroughs made in this emerging discipline over the last decade. As such, the book provides an overview of the latest developments and future trends in the field, focusing on such applications as the development of potenti...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
[Place of publication not identified] :
John Wiley and Sons, Inc.,
2014.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 505 | 0 | |6 880-01 |a Bioorganometallic Chemistry: Applications in Drug Discovery, Biocatalysis, and Imaging; Contents; List of Contributors; Preface; Part One: Medicinal Chemistry; 1. Organometallic Complexes as Enzyme Inhibitors: A Conceptual Overview; 1.1 Introduction; 1.2 Organometallic Compounds as Inert Structural Scaffolds for Enzyme Inhibition; 1.3 Organometallic Compounds Targeting Specific Protein Residues; 1.4 The Bioisosteric Substitution; 1.5 Novel Mechanisms of Enzyme Inhibition with Organometallic Compounds; 1.6 Organometallic Compounds as Cargo Delivers of Enzyme Inhibitors. | |
| 505 | 8 | |a 1.7 Organometallic Enzyme Inhibitors for Theranostic Purposes1.8 Conclusion; Acknowledgments; Abbreviations; References; 2. The Biological Target Potential of Organometallic Steroids; 2.1 Introductory Note on Nuclear Receptors; 2.1.1 Early History; 2.1.2 Primary Structure of Nuclear Receptors; 2.1.3 Estrogen Receptors; 2.1.4 Androgens; 2.1.5 Glucocorticoids; 2.1.6 Progesterone and Progestogens; 2.1.7 Mineralocorticoids and Aldosterone; 2.1.8 Selective Modulators of Nuclear Receptors; 2.1.8.1 Selective Estrogen Receptor Modulators (SERMs); 2.1.8.2 Selective Androgen Receptor Modulators (SARMs). | |
| 505 | 8 | |6 880-02 |a 2.2.4 Approach Toward Organometallic Radiopharmaceuticals2.2.4.1 Steroidal Derivatives; 2.2.4.2 Nonsteroidal Complexes; 2.3 Epilog; Acknowledgments; References; 3. Chirality in Organometallic Anticancer Complexes; 3.1 Introduction; 3.2 Chirality in Arene Complexes; 3.3 CIP System for the Nomenclature of Chiral-at-Metal Arene Complexes; 3.4 Chiral Organometallic Complexes as Anticancer Agents; 3.4.1 Chiral Carbene Complexes; 3.4.2 Chiral Metallocene Complexes; 3.4.3 Chiral Half-Sandwich Arene Complexes; 3.4.4 Chirality at Metal in Supramolecular Complexes. | |
| 520 | |a An up-to-date reference reflecting the significant advances and important breakthroughs made in this emerging discipline over the last decade. As such, the book provides an overview of the latest developments and future trends in the field, focusing on such applications as the development of potentially active organometallic drugs against incurable diseases, as well as in such areas as catalysis, energy, analytical chemistry, and imaging. The renowned editor, who established the term ""bioorganometallics"", and his international team of experts have put together a valuable resource for research. | ||
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Organometallic compounds. | |
| 650 | 0 | |a Drugs. | |
| 650 | 2 | |a Organometallic Compounds |x chemistry | |
| 650 | 2 | |a Organometallic Compounds |x pharmacology | |
| 650 | 2 | |a Organometallic Compounds |x therapeutic use | |
| 650 | 2 | |a Pharmaceutical Preparations | |
| 650 | 2 | |a Organometallic Compounds | |
| 650 | 6 | |a Composés organométalliques. | |
| 650 | 6 | |a Médicaments. | |
| 650 | 7 | |a organometallic compound. |2 aat | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Biochemistry. |2 bisacsh | |
| 650 | 7 | |a Drugs |2 fast | |
| 650 | 7 | |a Organometallic compounds |2 fast | |
| 650 | 7 | |a Biomolekül |2 gnd | |
| 650 | 7 | |a Metallorganische Chemie |2 gnd | |
| 650 | 7 | |a Metallorganische Verbindungen |2 gnd | |
| 650 | 7 | |a Pharmazeutische Chemie |2 gnd | |
| 700 | 1 | |a Jaouen, rard. | |
| 758 | |i has work: |a Bioorganometallic chemistry (Text) |1 https://id.oclc.org/worldcat/entity/E39PCGXvqPYWk68PGH9r3mrpKb |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
| 776 | 0 | 8 | |i Print version: |a G. & eacute. |t Bioorganometallic Chemistry. |z 3527335277 |z 9783527335275 |w (OCoLC)882530718 |
| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=1848234 |z Texto completo |
| 880 | 8 | |6 505-01/(S |a 3.5 Half-Sandwich Complexes with Chiral Metal Centers3.5.1 Factors Influencing the Chirality at the Metal Center; 3.5.1.1 Use of Chiral Ligands for Chiral Resolution at the Metal Center: Diastereoisomerism; 3.5.1.2 CH-π Interactions: β-Phenyl Effect and Hydrogen Bond Interactions; 3.5.1.3 Effect of the Temperature, Solvent and Ligands on the Metal Configuration; 3.6 Conclusions; Acknowledgments; References; 4. Gold Organometallics with Biological Properties; 4.1 Introduction: The Use of Gold in Medicine; 4.2 Anticancer Gold Organometallics and Proposed Biological Targets. | |
| 880 | 8 | |6 505-02/(S |a 2.1.8.3 Selective Progesterone Receptor Modulators (SPRMs)2.1.9 Mechanism of Action of Nuclear Receptors; 2.1.10 Endocrine Disruptors; 2.2 Steroids and Organometallics: An Overview of the Transitional Period from the Use of Organometallics in Synthesis to the Emergence of Bioorganometallics; 2.2.1 Early Examples of Organometallic Estradiol Derivatives with Biological Potential: Modified Hormone Shown to Bind to Estrogen Receptor α; 2.2.2 Examples of Estrogens Modified by Organometallics at the 11β-Position; 2.2.3 Targeting Prostate Cancer with Organometallic Androgens and Antiandrogens. | |
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