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Laboratory hemostasis : a practical guide for pathologists /
Coagulation testing is the basis for the diagnosis of bleeding and thrombotic disorders, as well as the mainstay of anticoagulant monitoring and management. This handbook provides practical information and guidance on topics relevant to directing a coagulation laboratory, filling a void in the liter...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York :
Springer,
[2014]
|
| Edición: | Second edition. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Preface; Contents; 1: Role and Responsibilities of the Laboratory Director; 1.1 General Responsibilities; 1.2 Personnel; 1.3 Facilities and Safety; 1.4 Test Procedures; 1.5 Quality Management; 1.6 Consultation and Education; 1.7 Communication; 1.8 Operational Management; 1.9 Resources; 1.10 Common Pitfalls; 1.11 Summary and Key Points; References; 2: Collection of Coagulation Specimens; 2.1 Collection of Specimens for Hemostasis Testing; 2.2 Citrate Anticoagulant Concentration; 2.3 Plastic vs. Glass Tubes; 2.4 Collection Techniques; 2.5 Specimen Preparation; 2.6 Specimen Stability.
- 2.7 Problem Detection and Actions2.8 Coagulation Testing on Specimens Other than Citrated Plasma; 2.9 Common Pitfalls; 2.10 Summary and Key Points; References; 3: Instrumentation for the Coagulation Laboratory; 3.1 Laboratory Instruments; 3.1.1 Test Methodologies; 3.1.2 Detection Methods; 3.2 Point of Care Instruments; 3.2.1 Waived PT/INR Instruments; 3.2.2 POC Analyzers Designed for Coagulation Monitoring During Invasive Procedures; 3.2.3 Viscoelastic Analyzers; 3.2.4 Platelet Function Analyzers; 3.3 Platelet Aggregometry; 3.3.1 Light Transmission Aggregometers (LTA).
- 3.3.2 Multiplate® Analyzer3.3.3 PFA-100®; 3.3.4 Plateletworks®; 3.3.5 VerifyNow"! 3.4 Summary and Key Points; References; 4: Validation of Hemostasis Assays, Analyzers, and Reagents; 4.1 Validation Overview; 4.2 Validation Tools; 4.3 Validation Studies; 4.4 Validation Plan; 4.5 Analyzer Set-up and Utilities; 4.6 Calibration and Calibration Verification; 4.7 Quality Control Ranges; 4.8 Reference Intervals; 4.9 Performance Characteristics; 4.10 Method Comparisons; 4.11 INR; 4.12 Heparin Therapeutic Ranges; 4.13 Instrument Interfaces; 4.14 Reports; 4.15 Implementation Readiness; 4.16 Approval.
- 4.17 "Full" Versus "Partial" Validations4.18 Other Considerations; 4.19 Common Pitfalls; 4.20 Summary and Key Points; References; 5: Hemostasis Screening Assays; 5.1 Hemostasis Screening Assays: Use and Interpretation; 5.2 The CBC; 5.3 The PT Assay; 5.4 The PTT Assay; 5.5 The Mixing Test (Inhibitor Screen); 5.6 The Thrombin Time Assay; 5.7 Fibrinogen Assays; 5.8 D-dimer Assays; 5.9 The Bleeding Time (BT) Test; 5.10 Interpretation of Hemostasis Screening Tests in Patients with Bleeding Disorders; 5.11 Key Points; References; 6: Testing for Inherited Bleeding Disorders.
- 6.1 Qualitative Platelet Disorders6.2 Platelet Aggregation; 6.3 von Willebrand's Disease; 6.4 Assays for vWF; 6.5 vWF Immunoassay; 6.6 Ristocetin Cofactor Activity (vWF Activity) Assay; 6.7 Factor VIII Activity Assay; 6.8 vWF Multimeric Analysis; 6.9 Appropriate Test Ordering for Platelet-Type Bleeding Disorders; 6.10 The Platelet Function Analyzer (PFA)-100®; 6.11 Inherited Coagulation Disorders; 6.12 Factor XIII (Clot Stability) Assay; 6.13 Fibrinogen Activity Assay; 6.14 Alpha2-Antiplasmin Assay; 6.15 Assays for Factor VIII Antibodies (Inhibitor Assays); 6.16 Key Points; References.