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Multicomponent reactions in organic synthesis /
Comprehensive and up-to-date, this book focuses on the latest advances in the field, such as newly developed techniques, more environmentally benign processes, broadened scopes, and completely novel MCRs. In addition to carbene-promoted MCRs and frequently applied metal-catalyzed MCRs, it also cover...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Weinheim, Germany :
Wiley,
©2015.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Multicomponent Reactions in Organic Synthesis; Contents; List of Contributors; Preface; 1. General Introduction to MCRs: Past, Present, and Future; 1.1 Introduction; 1.2 Advances in Chemistry; 1.3 Total Syntheses; 1.4 Applications in Pharmaceutical and Agrochemical Industry; 1.5 Materials; 1.6 Outlook; References; 2. Discovery of MCRs; 2.1 General Introduction; 2.2 The Concept; 2.3 The Reaction Design Concept; 2.3.1 Single Reactant Replacement; 2.3.2 Modular Reaction Sequences; 2.3.3 Condition-Based Divergence; 2.3.4 Union of MCRs; 2.4 Multicomponent Reactions and Biocatalysis.
- 2.4.1 Multicomponent Reactions and (Dynamic) Enzymatic Kinetic Resolution2.4.2 Multicomponent Reactions and Enzymatic Desymmetrization; 2.5 Multicomponent Reactions in Green Pharmaceutical Production; 2.6 Conclusions; Acknowledgments; References; 3. Aryne-Based Multicomponent Reactions; 3.1 Introduction; 3.2 Multicomponent Reactions of Arynes via Electrophilic Coupling; 3.2.1 Multicomponent Reactions under Neutral Conditions; 3.2.1.1 Isocyanide-Based Multicomponent Reactions; 3.2.1.2 Imine-Based Multicomponent Reactions; 3.2.1.3 Amine-Based Multicomponent Reactions.
- 4.2.1 Phenols and Thiophenols4.2.2 Six-Membered Ring Hydroxy Heteroaromatics and Related Mercaptans; 4.2.3 Five-Membered Ring Hydroxy Heteroaromatic and Related Mercaptans; 4.2.4 Related Couplings with Enol Derivatives; 4.2.5 The Joullié-Smiles Coupling; 4.2.6 The Passerini-Smiles Reaction; 4.3 Ugi-Smiles Postcondensations; 4.3.1 Postcondensations Involving Reduction of the Nitro Group; 4.3.2 Transformations of Ugi-Smiles Thioamides; 4.3.3 Postcondensations Involving Transition Metal-Catalyzed Processes; 4.3.4 Reactivity of the Peptidyl Unit; 4.3.5 Radical Reactions; 4.3.6 Cycloaddition.
- 4.4 ConclusionsReferences; 5. 1,3-Dicarbonyls in Multicomponent Reactions; 5.1 Introduction; 5.2 Achiral and Racemic MCRs; 5.2.1 Involving One Pronucleophilic Reactive Site; 5.2.2 Involving Two Reactive Sites; 5.2.2.1 Two Nucleophilic Sites; 5.2.2.2 One Pronucleophilic Site and One Electrophilic Site; 5.2.3 Involving Three Reactive Sites; 5.2.4 Involving Four Reactive Sites; 5.3 Enantioselective MCRs; 5.3.1 Involving One Reactive Site; 5.3.2 Involving Two Reactive Sites; 5.3.3 Involving Three Reactive Sites; 5.4 Conclusions and Outlook; References; 6. Functionalization of Heterocycles by MCRs.