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Chemistry of drugs /
| Clasificación: | Libro Electrónico |
|---|---|
| Autores principales: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Pharmaceutical Press,
2014.
|
| Colección: | FASTtrack.
|
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover; Title Page; Copyright; Contents; Introduction to the FASTtrack series; Preface; About the authors; Chapter 1. Chemical structure and bonding; Cations and anions; Electron orbitals; Electronic configuration; Molecular orbitals; Promotion; Hybridisation; Bonding; Valence shell electron pair repulsion (VSEPR); Nucleophiles and electrophiles; Drawing chemical structures; Resonance/mesomerism; Drawing resonance hybrids; Self-assessment; Chapter 2. Intermolecular interactions; Importance of intermolecular interactions in pharmacy; Coulombic/electrostatic interactions.
- Van der Waals interactionsHydrogen bond interactions; Molecular affinity and the free energy of interaction; Self-assessment; Chapter 3. Acids and bases; Definitions of acids and bases; Acid and base strength; Quantifying the strengths of acids and bases: pKa and pKb values; Importance of acids and bases in pharmacy; Common acidic and basic functional groups; pH and pKa; Amphoteric compounds; Simple buffer solutions; Universal buffer solutions; Self-assessment; Chapter 4. Stereochemistry; Stereochemistry and its importance in pharmaceutical science; Stereoisomers.
- Fischer's convention of stereochemical nomenclatureConformational isomers; Stereoisomers of cyclic molecules; Geometric isomers; Topological isomers; Self-assessment; Chapter 5. Chemical reaction mechanisms; Nucleophiles and electrophiles; Reaction mechanisms; Curly arrows in reaction mechanisms; Radicals in reaction mechanisms; Fish hooks in reaction mechanisms; Chemical reactivity; Self-assessment; Chapter 6. Chemistry of electrophiles and nucleophiles; Addition and substitution reactions; Electrophilic addition; Nucleophilic substitution; Elimination reactions.
- Competition between substitution and eliminationSelf-assessment; Chapter 7. Chemistry of aromatic compounds; Benzene; Naming of benzene derivatives; Reactivity; Electrophilic substitution; Electrophilic substitution versus electrophilic addition; Examples of electrophilic substitution; Monosubstituted benzene derivatives; Halogen substituents; Disubstituted benzene derivatives; Self-assessment; Chapter 8. Chemistry of carbonyl compounds; Reactivity of the carbonyl group; Nucleophilic addition; Changes in hybridisation during nucleophilic addition; Stereochemistry in nucleophilic addition.